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ganciclovir ophthalmic (Rx)Brand and Other Names:Vitrasert, Zirgan

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

implant

  • 4.5mg

ophthalmic gel

  • 0.15% (5g)
more...

CMV Retinitis

Ocular Implant: Intravitreally 1 implant q5-8mth

Acute Herpetic Keratitis

Initial: 1 gtt to affected eye(s) 5 x per day while awake until corneal ulcer heals

Maintenance: 1 gtt to affected eye(s) TID for 7 days

Dosage Forms & Strengths

implant

  • 4.5mg

ophthalmic gel

  • 0.15% (5g)
more...

CMV Retinitis

<9 years: Safety and efficacy not established

9 years or older: As adults; ocular implant: intravitreally 1 implant q5-8mth

Acute Herpetic Keratitis

<2 years: Safety and efficacy not established

2 years or older: As adults

Initial: 1 gtt to affected eye(s) 5 x per day while awake until corneal ulcer heals

Maintenance: 1 gtt to affected eye(s) TID for 7 days

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Adverse Effects

>10%

Zirgan

  • Blurred vision (60%)
  • Eye irritation (20%)

Vitrasert

  • Visual acuity loss (10-20%)
  • Retinal detachment (10-20%)
  • Vitreous hemorrhage (10-20%)

1-10%

Zirgan

  • Punctate keratitis (5%)
  • Conjunctival hyperemia (5%)

Frequency Not Defined

Vitrasert

  • Uveitis
  • Hyphema
  • Macular degeneration
  • IOP spike
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Warnings

Contraindications

Hypersensitivity to ganciclovir or acyclovir

Intraocular surgery eg, external infection or severe thrombocytopenia

Cautions

Handle implant only by suture tab

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: excretion in milk unknown; use with caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Release Rate (Vitrasert): 1.4 mcg/hr; range 0.5-2.88 mcg/hr

Mechanism of Action

Inhibits replication of viral DNA

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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