voreloxin (Discontinued)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Acute Myelogenous Leukemia (Investigational/Orphan Status)

Refractory/relapsed AML: 80-90 mg/sq.meter IV on days 1 and 4 (with cytarabine)

Elderly patients with newly diagnosed AML: 72 mg/sq.meter IV x2 doses on days 1 and 8

Ovarian Cancer, Platinum-Resistant (Investigational)

60-75 mg/sq.meter IV q4wk; infuse IV over 5-10 min

Not applicable

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Adverse Effects

>10%

Mucositis (dose-limiting)

Neutropenia

Fatigue

Anemia

Nausea

Vomiting

Hypokalemia

Anorexia

Upper GI (mucosal inflammation)

Lower GI (diarrhea/colitis)

Hypokalemia

Hypophosphatemia

Hypocalcemia

Dehydration

Confusional state

Dyspnea

Infections (bacterial pneumonia, sepsis, bacteremia, other)

Hypotension

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Warnings

Data limited, unknown

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Pregnancy & Lactation

Pregnancy Category: D

Lactation: not known whether distributed in breast milk, do not breast feed

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: glucuronide conjugation, oxidation, N-dealkylation, O-dealkylation

Mechanism of Action

Anticancer quinolone derivative; elicits intercalation into DNA and blocks religation of topoisomerase II-induced double-strand breaks at selective sites in DNA, leading to G2 arrest and cell death by apoptosis

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Administration

Data limited

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Images

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