miconazole/petrolatum/zinc oxide topical (Rx)Brand and Other Names:Vusion

 
 
 

Dosing & Uses

AdultPediatric

Not indicated

Dosage Forms & Strengths

miconazole/petrolatum/zinc oxide

topical ointment

  • 0.25%/81.35%/15%
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Diaper Dermatitis

Indicated as adjunctive treatment of diaper dermatitis only when complicated by documented candidiasis

<4 weeks: Safety and efficacy not established

≥4 weeks: Apply thin layer to diaper area at each diaper change for 7 days

Administration

Before applying, gently cleanse the skin with lukewarm water and pat dry with a soft towel

Avoid using any scented soaps, shampoos, or lotions on the diaper area

Continue treatment for the full 7 days, even if there is improvement; do not apply longer than 7 days, if symptoms have not improved by day 7, contact healthcare provider

Gently apply a thin layer of ointment to the diaper area with the fingertips; do not rub into the skin as this may cause additional irritation

Thoroughly wash hands after application

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Adverse Effects

Postmarketing Reports

Skin: Burning sensation, condition aggravated, inflammation, pruritus, rash, skin exfoliation

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Warnings

Contraindications

None

Cautions

Not a substitute for frequent diaper changes

If irritation occurs or worsens, discontinue use and contact healthcare provider

Safety and efficacy not demonstrated in immunocompromised patients or incontinent adults

Should not be used to prevent diaper dermatitis (ie, adult institutional setting); preventive use may result in drug resistance

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Unknown whether distributed in breast milk

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Miconazole: Antifungal agent; elicits in vitro activity against Candida albicans by inhibiting ergosterol biosynthesis in the cell membrane; accumulation of ergosterol precursors and toxic peroxides results in cytolysis of the cell

Absorption

Negligible

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Images

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Formulary

FormularyPatient Discounts

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Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
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Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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