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stavudine (Rx)Brand and Other Names:Zerit, d4T

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 15mg
  • 20mg
  • 30mg
  • 40mg

oral solution

  • 1mg/mL (200mL)
more...

HIV Infection

>60 kg: 40 mg PO BID

<60 kg: 30 mg PO BID

Renal Impairment

>60 kg

  • CrCl >50 mL/min: 40 mg PO q12hr
  • CrCl 26-50 mL/min: 20 mg PO q12hr
  • CrCl 10-25 mL/min: 20 mg PO qD

<60 kg

  • CrCl >50 mL/min: 30 mg PO q12hr
  • CrCl 26-50 mL/min: 15 mg PO q12hr
  • CrCl 10-25 mL/min: 15 mg PO qD

Dosage Forms & Strengths

capsule

  • 15mg
  • 20mg
  • 30mg
  • 40mg

oral solution

  • 1mg/mL (200mL)
more...

HIV Infection

Birth-13 days: 0.5 mg/kg PO q12hr 

<30 kg, >14 days: 1 mg/kg PO q12hr

30-<60 kg: As adults; 30 mg PO BID

>60 kg: As adults; 40 mg PO BID

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Interactions

Interaction Checker

stavudine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Headache

            Chills/fever

            Malaise

            Insomnia

            Anxiety

            Depression

            Pain

            Rash

            Nausea

            Vomiting

            Diarrhea

            Pancreatitis

            Abdominal pain

            Peripheral neuropathy

            1-10%

            Neutropenia

            Thrombocytopenia

            Incr hepatic transaminases

            Incr bilirubin

            Myalgia

            Back pain

            Weakness

            Postmarketing Reports

            Metabolic disorders: lipoatrophy, lipodystrophy

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            Warnings

            Black Box Warnings

            Fatal and nonfatal pancreatitis reported; suspend if pancreatitis suspected and discontinue if confirmed

            Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) reported with use of nucleoside analogues alone or in combination

            Fatal lactic acidosis reported in pregnant women who have received didanosine and stavudine with other antiretroviral agents. Use the combination with caution in pregnant women

            Contraindications

            Hypersensitivity

            Cautions

            Risk of potentially fatal lactic acidosis & severe hepatomegaly with steatosis, with use alone & especially with didanosine

            Risk of potentially fatal pancreatitis when used with didanosine

            Decr dose in renal impairment

            Risk of immune reconstitution syndrome if used in combination w/ other antiretroviral drugs

            Randomized controlled trials found lipoatrophy or lipodystrophy developed in a higher proportion of patients treated with stavudine compared to other nucleosides (tenofovir or abacavir)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: HIV+ women are advised not to breastfeed

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Half-Life: 1-1.6 hr

            Peak Plasma Time: 1 hr; 3 hr (XR)

            Peak Plasma Concentration: (conventional) 228±62 ng/mL; (XR) 536±146 ng/mL

            AUC: (conventional) 1966±629 ng.hr/mL; (XR) 2568±454 ng.hr/mL

            Bioavailability: 86.4%

            Vd: 0.5 L/kg

            Clearance: 594±165 mL/min (total body); 237±98 mL/min (renal)

            Excretion: urine

            Mechanism of Action

            Nucleoside Reverse Transcriptase Inhibitor (NRTI)

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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