pentetate zinc trisodium (Rx)

Brand and Other Names:Zn DTPA, Zinc DTPA
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable/inhalable solution

  • 1g/5mL vial
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Internal Contamination with Plutonium, Americium, Curium

1 g slow IV push over 3-4 min OR

IV infusion (in 100-250 mL D5W or LR or NS) OR

Inhalation in a nebulizer (1:1 with water or saline)

IV administration should not be protracted over >2 hours

Can be administered undiluted by IM if IV is not practical; coadministration of 1-2% procaine may alleviate injection site pain

Generally used after initial decontamination with the more potent Ca-DTPA

Full decontamination may require prolonged treatment

Other Indications & Uses

Less effective but less toxic than Ca-DTPA

Dosage Forms & Strengths

injectable/inhalable solution

  • 1g/5mL vial
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Internal Contamination with Plutonium, Americium, Curium

<12 years old: 14 mg/kg IV qDay, no more than 1 g/day

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Adverse Effects

Frequency Not Defined

(Repeated administration over a short period): chills, fever, muscle cramps, nausea, pruritus, vomiting

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Warnings

Not for uranium or neptunium

Do not divide dose

May lead to depletion of endogenous trace metals on several months use

Nebulized soln may exacerbate asthma

Pregnancy, kidney dz

Monitor BP during infusion

Obtain written consent for tx

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: N/A

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Distribution: In extracellular fluid, very little in cells/tissues

Metabolism: minimal

Excretion: predominantly in urine, almost completely in 12 hr; feces <3%

Zn-DTPA (Akorn, Inc, call 1-800-932-5676; [inj/inh soln]: 1 g/5 mL vial)

Mechanism of Action

Chelates transuranium metals

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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