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zoster vaccine live (Rx)Brand and Other Names:Zostavax

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injection solution

  • 19,400 PFU/0.65 mL
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Varicella-Zoster Virus Infection

0.65 mL (entire content of vial ) injected SC into upper arm as single dose

FDA approved as single dose for adults ≥50 years, regardless of whether they report prior episodes of herpes zoster; although vaccine is FDA-licensed for patients ≥50 years, Advisory Committee on Immunization Practices (ACIP) recommends that vaccination begin at 60 years; up-to-date vaccination schedules available at http://www.cdc.gov/vaccines/schedules/hcp/index.html

Administration

Reconstitute vaccine by using diluent supplied, first withdrawing all contents of diluent vial into syringe, then injecting solution into vial of lyophilized vaccine, and finally agitating to mix

Use separate needles and syringes for reconstituting and administration

Administer immediately after reconstitution

Inject total volume of reconstituted vaccine SC into upper arm

Discard if not used within 30 minutes

Not indicated

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Interactions

Interaction Checker

zoster vaccine live and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Suspected adverse events after administration of vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS) at 1-800-822-7967

            >10%

            Injection-site erythema

            Pain or tenderness

            Pruritus

            Swelling

            Warmth

            1-10%

            Diarrhea (2%)

            Fever (2%)

            Flulike syndrome (2%)

            Upper respiratory tract infection (2%)

            Headache (1%)

            Rhinitis (1%)

            Skin disorder (1%)

            Weakness (1%)

            <1%

            Arthralgia

            Hypersensitivity

            Injection-site reactions

            Postmarketing Report

            Herpes zoster

            Necrotizing retinitis (patients on immunosuppressive therapy)

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            Warnings

            Contraindications

            Hypersensitivity to gelatin, neomycin

            Pregnancy

            Not to be administered to immunosuppressed or immunodeficient individuals, including (1) those with a history of primary or acquired immunodeficiency states, leukemia, lymphoma, or other malignant neoplasms affecting bone marrow or lymphatic system; (2) those with AIDS or other clinical manifestations of infection with HIV; (3) those receiving immunosuppressive therapy; (4) those with active tuberculosis

            Cautions

            Treatment provision (including epinephrine injection 1:1000) should be available for immediate use

            Defer vaccination in patients with active untreated tuberculosis or acute illness

            May not protect all vaccine recipients

            Not to be given with 23-valent pneumococcal vaccine; concomitant use decreases immunogenicity of varicella-zoster virus (VZV) vaccine

            Transmission of vaccine virus may occur between vaccinees and susceptible contacts (rare)

            Not indicated for prevention of primary VZV infection (chickenpox)

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Unknown whether agent is excreted in breast milk; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Conveys active immunity by stimulating production of endogenously produced antibodies

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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