cetirizine/pseudoephedrine (OTC)

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Brand and Other Names:Zyrtec D

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

cetirizine/pseudoephedrine

tablet, extended-release

  • 5mg/120mg
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Allergic Rhinitis

Indicated to relieve nasal and non-nasal symptoms associated with seasonal or perennial allergic rhinitis

1 tablet PO q12hr with or without food; not to exceed 2 tabs/day

Renal Impairment

Hemodialysis or CrCl <32 mL/min: 1 tablet PO qDay

Hepatic Impairment

1 tablet PO qDay

Dosage Forms & Strengths

cetirizine/pseudoephedrine

tablet, extended-release

  • 5mg/120mg
more...

Allergic Rhinitis

Indicated to relieve nasal and non-nasal symptoms associated with seasonal or perennial allergic rhinitis

<12 years: Safety and efficacy not established

≥12 years: As adults; 1 tablet PO q12hr with or without food; not to exceed 2 tabs/day

Renal Impairment

Hemodialysis or CrCl <32 mL/min: 1 tablet PO qDay

Hepatic Impairment

1 tablet PO qDay

May require decreased dose of 1 tablet PO qDay depending on renal function

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Interactions

Interaction Checker

and cetirizine/pseudoephedrine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Insomnia (4%)

            Xerostomia (4%)

            Fatigue/somnolence (2%)

            Pharyngitis (2%)

            Dizziness (1%)

            Epistaxis (1%)

            Sinusitis (1%)

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            Warnings

            Contraindications

            Hypersensitivity

            Narrow-angle glaucoma

            Urinary retention

            Severe hypertension

            Severe coronary artery disease

            Within 14 days of taking MAOIs

            Cautions

            Adrenergic agents may cause arrhythmias, dizziness, insomnia, tremor, or weakness

            May cause sedation; caution with tasks requiring cognitive abilities (eg, driving, operating machinery)

            Alcohol may exacerbate sedation and cognitive abilities

            Caution with history of diabetes mellitus, hypertension, hyperthyroidism, increased IOP, ischemic heart disease, prostatic hypertrophy, or renal function impairment

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Each ingredient is distributed in breast milk, caution advised

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Cetirizine: Histamine H1-receptor antagonist

            Pseudoephedrine: Alpha adrenergic agonist; decongestant in respiratory tract mucous membranes

            Pharmacokinetics

            Half-Life: 7.9 hr (cetirizine); 6 hr (pseudoephedrine)

            Onset: 20-60 min (cetirizine); 30 min (pseudoephedrine)

            Vd: 2.6-3.3 L/kg (cetirizine)

            Peak Plasma Time:2.2 hr (cetirizine); 4.4 hr (pseudoephedrine)

            Peak Plasma Concentration: 422 ng/mL (pseudoephedrine)

            Protein Bound: 93% (cetirizine)

            Metabolism: Liver, low first-pass (cetirizine)  

            Clearance:  7.3-7.6 mL/min/kg (pseudoephedrine)

            Excretion: Cetirizine: feces (10%), urine (70%); pseudoephedrine: urine

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            Images

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