Pediatric Hypothyroidism Medication

1. Aversa T, Valenzise M, Corrias A, Salerno M, De Luca F, Mussa A, et al. Underlying Hashimoto's thyroiditis negatively affects the evolution of subclinical hypothyroidism in children irrespectively of other concomitant risk factors. Thyroid. 2014 Nov 3. [Medline].

2. Wassner AJ, Brown RS. Congenital hypothyroidism: recent advances. Current Opinion in Endocrinology, Diabetes and Obesity. 2015 Oct. 22(5):407-12. [Medline].

3. Chung HR. Adrenal and thyroid function in the fetus and preterm infant. Korean J Pediatr. 2014 Oct. 57(10):425-33. [Medline]. [Full Text].

4. Dalili S, Rezvani SM, Dalili H, Mohtasham Amiri Z, Mohammadi H, Abrisham Kesh S, et al. Congenital hypothyroidism: etiology and growth-development outcome. Acta Med Iran. 2014 Oct. 52(10):752-6. [Medline].

5. Zwaveling-Soonawala N, van Trotsenburg AS, Verkerk PH. The severity of congenital hypothyroidism of central origin should not be underestimated. J Clin Endocrinol Metab. 2014 Oct 27. jc20142871. [Medline].

6. Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, et al. European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. Hormone Research in Paediatrics. 2014. 81(2):80-103. [Medline].

7. Abalovich M, Amino N, Barbour LA, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2007. 92(8 Suppl):S1-47. [Medline].

8. Abe K, Narumi S, Suwanai AS, Hamajima T, Hasegawa T. Pseudodominant inheritance in a family with nonautoimmune hypothyroidism due to biallelic DUOX2 mutations. Clin Endocrinol (Oxf). 2014 Sep 26. [Medline].

9. Ayala AR, Danese MD, Ladenson PW. When to treat mild hypothyroidism. Endocrinol Metab Clin North Am. 2000 Jun. 29(2):399-415. [Medline].

10. Bongers-Schokking JJ, Koot HM, Wiersma D, et al. Influence of timing and dose of thyroid hormone replacement on development in infants with congenital hypothyroidism. J Pediatr. 2000 Mar. 136(3):292-7. [Medline].

11. Brown RS, Bellisario RL, Botero D, et al. Incidence of transient congenital hypothyroidism due to maternal thyrotropin receptor-blocking antibodies in over one million babies. J Clin Endocrinol Metab. 1996 Mar. 81(3):1147-51. [Medline].

12. Brown RS, Keating P, Mitchell E. Maternal thyroid-blocking immunoglobulins in congenital hypothyroidism. J Clin Endocrinol Metab. 1990 May. 70(5):1341-6. [Medline].

13. Cho MS, Cho GS, Park SH, Jung MH, Suh BK, Koh DG. Earlier re-evaluation may be possible in pediatric patients with eutopic congenital hypothyroidism requiring lower L-thyroxine doses. Ann Pediatr Endocrinol Metab. 2014 Sep. 19(3):141-5. [Medline]. [Full Text].

14. Cross G, Pitoia F, Suárez H, Kral M, Manavela M, Morando D, et al. High prevalence of thyroid disorders in relatives of patients with familial papillary thyroid cancer. Medicina (B Aires). 2010. 70(2):139-142. [Medline].

15. Daliva AL, Linder B, DiMartino-Nardi J, Saenger P. Three-year follow-up of borderline congenital hypothyroidism. J Pediatr. 2000 Jan. 136(1):53-6. [Medline].

16. DeBoer MD, Lafranchi SH. Pediatric thyroid testing issues. Pediatr Endocrinol Rev. 2007. 5 Suppl 1:570-7. [Medline].

17. Dubuis JM, Glorieux J, Richer F, et al. Outcome of severe congenital hypothyroidism: closing the developmental gap with early high dose levothyroxine treatment. J Clin Endocrinol Metab. 1996 Jan. 81(1):222-7. [Medline].

18. Dussault JH. Childhood primary hypothyroidism and endemic cretinism. Curr Ther Endocrinol Metab. 1997. 6:107-9. [Medline].

19. Dussault JH. The anecdotal history of screening for congenital hypothyroidism. J Clin Endocrinol Metab. 1999 Dec. 84(12):4332-4. [Medline].

20. Fisher DA. The importance of early management in optimizing IQ in infants with congenital hypothyroidism. J Pediatr. 2000 Mar. 136(3):273-4. [Medline].

21. Fisher DA, Schoen EJ, La Franchi S, et al. The hypothalamic-pituitary-thyroid negative feedback control axis in children with treated congenital hypothyroidism. J Clin Endocrinol Metab. 2000 Aug. 85(8):2722-7. [Medline].

22. Franceschi R, Camilot M, Teofoli F. Thyrotropin receptor gene mutations and TSH resistance: variable expressivity in the heterozygotes. Clin Endocrinol (Oxf). 2005. 63:146-151. [Medline].

23. Garcia-Filion P, Epport K, Nelson M, et al. Neuroradiographic, endocrinologic, and ophthalmic correlates of adverse developmental outcomes in children with optic nerve hypoplasia: a prospective study. Pediatrics. 2008. 121:e653-9. [Medline].

24. Glinoer D, Delange F. The potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny. Thyroid. 2000 Oct. 10(10):871-87. [Medline].

25. Gruneiro-Papendieck L, Chiesa A, Mendez V. Efficacy of congenital hypothyroidism neonatal screening in preterms less than 32 weeks of gestational age: more evidence. J Pediatr Endocrinol Metab. 2005. 18:373-377. [Medline].

26. Guarnieri GF, Laforgia N, Mautone A, Balducci G. Delayed closure of ductus arteriosus in term newborns with congenital hypothyroidism: effect of L-thyroxine therapy. Pediatr Cardiol. 2008. 29:455-6. [Medline].

27. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine. 1999. 341(8):549-555. [Medline].

28. Hanukoglu A, Perlman K, Shamis I, et al. Relationship of etiology to treatment in congenital hypothyroidism. J Clin Endocrinol Metab. 2001 Jan. 86(1):186-91. [Medline].

29. Hardy O, Worley G, Lee MM, et al. Hypothyroidism in Down syndrome: screening guidelines and testing methodology. Am J Med Genet A. 2004. 124:436-7. [Medline].

30. Hashimoto K, Curty FH, Borges PP, et al. An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A. 2001 Mar 27. 98(7):3998-4003. [Medline].

31. Hopwood NJ, Kelch RP. Thyroid masses: approach to diagnosis and management in childhood and adolescence. Pediatr Rev. 1993 Dec. 14(12):481-7. [Medline].

32. Hsiao PH, Chiu YN, Tsai WY, et al. Intellectual outcome of patients with congenital hypothyroidism detected by neonatal screening. J Formos Med Assoc. 2001 Jan. 100(1):40-4. [Medline].

33. Hsiao PH, Chiu YN, Tsai WY, et al. Intellectual outcomes of patients with congenital hypothyroidism not detected by neonatal screening. J Formos Med Assoc. 1999 Jul. 98(7):512-5. [Medline].

34. Ishikawa N, Eguchi K, Ohmori T, et al. Defective organification of iodide causing congenital goitrous hypothyroidism. J Clin Endocrinol Metab. 1996 Jan. 81(1):376-83. [Medline].

35. Kempers MJ, van Trotsenburg AS, van Rijn RR, et al. Loss of integrity of thyroid morphology and function in children born to mothers with inadequately treated Graves' disease. J Clin Endocrinol Metab. 2007. 92:2984-91. [Medline].

36. Kordonouri O, Hartmann R, Riebel T, Liesenkoetter KP. Early treatment with L-thyroxine in children and adolescents with type 1 diabetes, positive thyroid antibodies, and thyroid gland enlargement. Pediatr Diabetes. 2007. 8:180-4. [Medline].

37. LaFranchi S. Congenital hypothyroidism: etiologies, diagnosis, and management. Thyroid. 1999 Jul. 9(7):735-40. [Medline].

38. LaFranchi S. Thyroid function in the preterm infant. Thyroid. 1999 Jan. 9(1):71-8. [Medline].

39. Lomenick JP, El-Sayyid M, Smith WJ. Effect of levo-thyroxine treatment on weight and body mass index in children with acquired hypothyroidism. J Pediatr. 2008. 152:96-100. [Medline].

40. McElduff A, McElduff P, Wiley V. Neonatal TSH as measured in a congenital hypothyroidism screening program: influence of the mode of delivery. J Clin Endocrinol Metab. 2005. [Medline].

41. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?. J Clin Endocrinol Metab. 2000 Nov. 85(11):3975-87. [Medline].

42. Muller AF, Berghout A, Wiersinga WM, Kooy A, Smits JW, Hermus AR. Thyroid function disorders - Guidelines of the Netherlands Association of Internal Medicine. Neth J Med. 2008. 66:134-42. [Medline].

43. Park SM, Chatterjee VK. Genetics of congenital hypothyroidism. J Med Genet. 2005. 42:379-389. [Medline].

44. Rovet JF. Congenital hypothyroidism: long-term outcome. Thyroid. 1999 Jul. 9(7):741-8. [Medline].

45. Ruiz M, Rajatanavin R, Young RA, et al. Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. N Engl J Med. 1982. 306:635-9. [Medline].

46. Sakata S, Matsuda M, Ogawa T, et al. Prevalence of thyroid hormone autoantibodies in healthy subjects. Clin Endocrinol (Oxf). 1994 Sep. 41(3):365-70. [Medline].

47. Sbrocchi AM, Chédeville G, Scuccimarri R, Duffy CM, Krishnamoorthy P. Pediatric hypothyroidism presenting with a polymyositis-like syndrome and increased creatinine: report of three cases. J Pediatr Endocrinol Metab. 2008. 21:89-92. [Medline].

48. Screening for congenital hypothyroidism: US Preventive Services Task Force reaffirmation recommendation. Ann Fam Med. 2008. 6:166. [Medline].

49. Topaloglu AK. Athyreosis, dysgenesis, and dyshormonogenesis in congenital hypothyroidism. Pediatr Endocrinol Rev. 2006. 3 Suppl 3:498-502. [Medline].

50. van der Sluijs Veer L, Kempers MJ, Last BF, Vulsma T, Grootenhuis MA. Quality of life, developmental milestones, and self-esteem of young adults with congenital hypothyroidism diagnosed by neonatal screening. J Clin Endocrinol Metab. 2008 May 6. [Medline].

51. van Tijn DA, de Vijlder JJ, Verbeeten B Jr. Neonatal detection of congenital hypothyroidism of central origin. J Clin Endocrinol Metab. 2005. 90:3350-3359. [Medline].

52. Van Vliet G. Neonatal hypothyroidism: treatment and outcome. Thyroid. 1999 Jan. 9(1):79-84. [Medline].

53. Veasey SC, Guilleminault C, Strohl KP, Sanders MH, Ballard RD, Magalang UJ. Medical therapy for obstructive sleep apnea: a review by the Medical Therapy for Obstructive Sleep Apnea Task Force of the Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep. 2006. 29:1036-44. [Medline].

54. Vela M, Gamboa S, Loera-Luna A, et al. Neonatal screening for congenital hypothyroidism in Mexico: experience, obstacles, and strategies. J Med Screen. 1999. 6(2):77-9. [Medline].

55. Working Group on Neonatal Screening of the European Society for Paediatric Endo. Revised guidelines for neonatal screening programmes for primary congenital hypothyroidism. Horm Res. 1999. 52(1):49-52. [Medline].

56. Zamproni I, Grasberger H, Cortinovis F, et al. Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism. J Clin Endocrinol Metab. 2008. 93:605-10. [Medline].

Sunil Kumar Sinha, MD Clinical Assistant Professor, Division of Pediatric Endocrinology, University of Arizona College of Medicine

Sunil Kumar Sinha, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Clinical Endocrinologists, Endocrine Society, Pediatric Endocrine Society

Disclosure: Nothing to disclose.

Andrew J Bauer, MD Director, The Thyroid Center, Division of Endocrinology, The Children's Hospital of Philadelphia

Andrew J Bauer, MD is a member of the following medical societies: American Academy of Pediatrics, American Thyroid Association, Pediatric Endocrine Society, Endocrine Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) Professor and Chair, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, Greece; UNESCO Chair on Adolescent Health Care, University of Athens, Greece

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) is a member of the following medical societies: American Academy of Pediatrics, American College of Physicians, American Pediatric Society, American Society for Clinical Investigation, Association of American Physicians, Endocrine Society, Pediatric Endocrine Society, Society for Pediatric Research, American College of Endocrinology

Disclosure: Nothing to disclose.

Sasigarn A Bowden, MD Associate Professor of Pediatrics, Section of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, Ohio State University College of Medicine; Pediatric Endocrinologist, Associate Fellowship Program Director, Division of Endocrinology, Nationwide Children’s Hospital; Affiliate Faculty/Principal Investigator, Center for Clinical Translational Research, Research Institute at Nationwide Children’s Hospital

Sasigarn A Bowden, MD is a member of the following medical societies: American Society for Bone and Mineral Research, Central Ohio Pediatric Society, Endocrine Society, International Society for Pediatric and Adolescent Diabetes, Pediatric Endocrine Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Thomas A Wilson, MD Professor of Clinical Pediatrics, Chief and Program Director, Division of Pediatric Endocrinology, Department of Pediatrics, The School of Medicine at Stony Brook University Medical Center

Thomas A Wilson, MD is a member of the following medical societies: Endocrine Society, Pediatric Endocrine Society, Phi Beta Kappa

Disclosure: Nothing to disclose.

Robert J Ferry Jr, MD Le Bonheur Chair of Excellence in Endocrinology, Professor and Chief, Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, University of Tennessee Health Science Center

Robert J Ferry Jr, MD is a member of the following medical societies: American Academy of Pediatrics, American Diabetes Association, American Medical Association, Endocrine Society, Pediatric Endocrine Society, Society for Pediatric Research, and Texas Pediatric Society

Disclosure: Eli Lilly & Co Grant/research funds Investigator; MacroGenics, Inc Grant/research funds Investigator; Ipsen, SA (formerly Tercica, Inc) Grant/research funds Investigator; NovoNordisk SA Grant/research funds Investigator; Diamyd Grant/research funds Investigator; Bristol-Myers-Squibb Grant/research funds Other; Amylin Other; Pfizer Grant/research funds Other; Takeda Grant/research funds Other

Ann Marie Straight, MD Fellow, Department of Pediatrics, Walter Reed Army Medical Center, National Naval Medical Center

Disclosure: Nothing to disclose.

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