Mumps Medication

Updated: Jan 17, 2019
  • Author: Germaine L Defendi, MD, MS, FAAP; Chief Editor: Russell W Steele, MD  more...
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Medication Summary

Treatment of mumps is usually supportive care. Vaccine pharmacotherapy is used to immunize the child.



Class Summary

These agents may be prescribed for severe headaches or discomfort and pain due to parotitis. For patients with orchitis, stronger analgesics may be needed.

Ibuprofen (Advil, Motrin, NeoProfen)

This is the drug of choice for patients with mild to moderate pain and fever. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Acetaminophen (Tylenol, Aspirin Free Anacin, FeverAll)

This is the drug of choice for pain in patients with documented hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), with upper GI disease, or who are taking PO anticoagulants. Acetaminophen reduces fever by acting directly on hypothalamic heat-regulating centers, which increases dissipation of body heat via vasodilation and sweating.


Vaccines (measles, mumps, rubella)

Class Summary

Prevention of mumps through immunization cannot be overemphasized. All children younger than 7 years should receive the mumps vaccine. In the United States, mumps vaccine is recommended and is usually combined with MMR.

The combined measles-mumps-rubella-varicella (MMRV) vaccine (ProQuad) has been shown to be associated with an increased risk of febrile seizure occurring 5-12 days following vaccination at a rate of 1 in 2300-2600 children, aged 12-23 months, compared with separate MMR vaccine and varicella vaccine administered simultaneously. [31, 32] As a result, the CDC Advisory Committee on Immunization Practices (ACIP) recommends that separate MMR and varicella vaccines be used for the first dose, although providers or parents may opt to use the combined MMRV vaccine for the first dose after counseling regarding this risk. [33] MMRV is preferred for the second dose (at any age) or for the first dose if given at age 48 months or older.

Data from postlicensure studies did not suggest that children aged 4-6 years who received the second dose of MMRV vaccine had an increased risk for febrile seizures after vaccination compared with children the same age who received MMR vaccine and varicella vaccine administered as separate injections at the same visit. [33]

Measles-mumps-rubella vaccine, live (MMR)

Live virus vaccine. Combined MMR vaccine is recommended for the prevention of mumps, measles, and rubella. For children, the typical recommended 2-dose schedule is administered at age 12-15 months for the 1st dose and age 4-6 years for the second dose.