Rickettsial Infection Medication

Updated: Jun 14, 2016
  • Author: Mobeen H Rathore, MD, CPE, FAAP, FIDSA; Chief Editor: Russell W Steele, MD  more...
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Medication

Medication Summary

Adequate antibiotic therapy initiated early is highly effective and associated with the best outcomes.

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Antibiotics

Class Summary

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Doxycycline (Bio-Tab, Doryx, Vibramycin)

DOC. Inhibits protein synthesis and, thus, bacterial growth by binding to 30S and, possibly, 50S ribosomal subunits of susceptible bacteria.

Chloramphenicol (Chloromycetin)

Binds to 50S bacterial-ribosomal subunits and inhibits bacterial growth by inhibiting protein synthesis. Effective against gram-negative and gram-positive bacteria. It may not be as effective against rickettsia as doxycycline.

If administered on an outpatient basis, 30% of patients subsequently require hospitalization, compared with 11% of patients treated with tetracyclines.

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