Polyhydramnios and Oligohydramnios Medication

Updated: Sep 20, 2017
  • Author: Brian S Carter, MD, FAAP; Chief Editor: Dharmendra J Nimavat, MD, FAAP  more...
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Medication

Medication Summary

Most cases of polyhydramnios respond in the first week of treatment with indomethacin. [19, 20, 21] This approach appears to be highly effective (90-100% in some studies), provided that the cause is not hydrocephalus or a neuromuscular disorder that alters fetal swallowing.

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Prostaglandin inhibitors

Class Summary

When administered to pregnant women with polyhydramnios, these drugs can reduce fetal urinary flow, decreasing the volume of amniotic fluid.

Indomethacin (Indocin)

Rapidly absorbed; metabolism occurs in liver by demethylation, deacetylation, and glucuronide conjugation; inhibits prostaglandin synthesis.

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