MGUS Prognosis

Determine risk of malignant progression to myleoma or lymphoproliferative disorder.

The global unit selector only affects unanswered questions
1.M-Protein Size?
2.M-Protein Type?
3.Serum Free Light Chain Ratio?
Created by

1. M-Protein Size?

Created by
0/3 completed

About this Calculator

Patients with monoclonal gammopathy of undetermined significance (MGUS) have an increased risk of developing a hematologic malignancy, most often multiple myeloma from IgG and IgA MGUS, and other malignant lymphoproliferative disorders from IgM MGUS. A previous large study from the Mayo Clinic of patients in Minnesota with MGUS detected an overall risk of progression of approximately 1% per year (Kyle 2002). This model from the same Minnesota population proposes a risk-stratification model based on serum M-protein concentration, type of paraprotein, and presence of an abnormal serum free kappa:lambda light chain ratio (Rajkumar 2005). This risk-stratification model may be useful in identifying MGUS patients with a high risk of progression as candidates for closer supervision and potential clinical trial strategies. It may also prove useful in identifying patients with a very low risk of malignant transformation and less intensive follow-up (BCSH MGUS Guidelines), although surveillance strategies based on this model require prospective study.


Kyle et al.

A long-term study of prognosis in monoclonal gammopathy of undetermined significance.

New England Journal of Medicine 2002 February 21, 346 (8): 564-9

Guidelines for the initial investigation and management of MGUS have been published by Bird et al. UK Myeloma Forum (UKMF) and Nordic Myeloma Study Group (NMSG): Guidelines for the investigation of newly detected M-proteins and the management of Monoclonal Gammopathy of Undetermined Significance (MGUS) - accessed June 13, 2009.

Legal Notices and Disclaimer

© 2020 QxMD Software Inc., all rights reserved. No part of this service may be reproduced in any way without express written consent of QxMD. This information should not be used for the diagnosis or treatment of any health problem or disease. This information is not intended to replace clinical judgment or guide individual patient care in any manner. Click here for full notice and disclaimer.