The time interval for the peak gradient to reach its midpoint (pressure half time) should not be used, in patients with high filling pressures, ASDs, significant AR or immediately after balloon valvuloplasty as it can underestimate the severity of MS.
Robert O Bonow, Blase A Carabello et al.
Circulation 2006 August 1, 114 (5): e84-231
Oh J, Seward JB, Tajik AJ.
The Echo Manual 3rd edition. Lippincott, Williams, Wilkins. 2007
Kern MJ.
The Cardiac Catheterization Handbook 4th Edition. Mosby 2003
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