Reynolds CAD Risk

The global unit selector only affects unanswered questions
2.Family History of Premature CAD?
3.Age (max 80 years)?
4.Systolic Blood Pressure?
5.High-Sensitivity C-Reactive Protein?
6.Total Cholesterol?
7.High-Density Lipoprotein Cholesterol?
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1. Smoker?

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About this Calculator

Premature CAD defined as a heart attack or stroke before age 60 years in a 1st degree relative.

Threshold cutoff values as follows:

  • If Systolic BP < 105 mmHg, a value of 105 mmHg is used.
  • If Total Cholesterol < 140 mg/dL, a value of 140 mg/dL is used.
  • If HDL < 30 mg/dL, then a value of 30 mg/dL is used.
  • If HDL > 150 mg/dL, then a value of 150 mg/dL is used.

*The risk stratification tool for the ESC is the SCORE system which estimates 10y risk of CVD death. Patients with a 10y risk of CVD death ≥5% are considered high risk. The lipid guidelines recognize risk equivalents as a distinct category that warrant immediate treatment. For patients with an ESC SCORE ≥ 5% a 3 month trial of lifestyle measures is a reasonable starting point. If after 3 months the lipids remain above moderate risk targets and the SCORE remains ≥ 5% then intensive therapy to reach high risk targets is recommended.


Ridker PM, Buring JE, Rifai N, Cook NR.

Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score.

JAMA: the Journal of the American Medical Association 2007 February 14, 297 (6): 611-9

European Guidelines on Cardiovascular disease prevention in clinical practice: Executive summary. EHJ 2007; 28; 2375-2414.

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