Assess disease activity in rheumatoid arthritis.
The Simplified Disease Activity Index for Rheumatoid Arthritis (SDAI) is a scoring system that has been validated in both research and clinical settings. It has been shown to have the highest sensitivity and specificity for predicting a physicians' decisions to change DMARD therapy when compared to other scores.
In an observational study, a score ≥15 had the best combination of sensitivity (90%) and specificity (86%) when compared to a clinical decision to change DMARDs because of inadequate control of disease. Remission is defined as an SDAI of <3.3, low disease activity as ≤11, moderate disease activity as ≤26 and high disease activity as >26.
Response to therapy is considered moderate if SDAI decreases by ≥7 and major if decreases by ≥17
SDAI is calculated as follows:
Where:
Smolen JS, Breedveld FC, Schiff MH, et. al.
Soubrier M et al.
The Simplified Disease Activity Index for Rheumatoid Arthritis (SDAI) is a scoring system that has been validated in both research and clinical settings. It has been shown to have the highest sensitivity and specificity for predicting a physicians' decisions to change DMARD therapy when compared to other scores.
In an observational study, a score ≥15 had the best combination of sensitivity (90%) and specificity (86%) when compared to a clinical decision to change DMARDs because of inadequate control of disease. Remission is defined as an SDAI of <3.3, low disease activity as ≤11, moderate disease activity as ≤26 and high disease activity as >26.
Response to therapy is considered moderate if SDAI decreases by ≥7 and major if decreases by ≥17
SDAI is calculated as follows:
Where:
Smolen JS, Breedveld FC, Schiff MH, et. al.
Soubrier M et al.
© 2020 QxMD Software Inc., all rights reserved. No part of this service may be reproduced in any way without express written consent of QxMD. This information should not be used for the diagnosis or treatment of any health problem or disease. This information is not intended to replace clinical judgment or guide individual patient care in any manner. Click here for full notice and disclaimer.
