Phenytoin has significant albumin binding and when total phenytoin level is measured, it is assumed that the amount bound to albumin versus free is predictable. In advanced renal failure, there is reduced phenytoin binding to albumin and one will tend to underestimate free phenytoin levels. The correction factor provided in this tool will provide a better sense of the adjusted phenytoin level, though a measure of free phenytoin is more reliable.
Phenytoin has significant albumin binding and when total phenytoin level is measured, it is assumed that the amount bound to albumin versus free is predictable. In advanced renal failure, there is reduced phenytoin binding to albumin and one will tend to underestimate free phenytoin levels. The correction factor provided in this tool will provide a better sense of the adjusted phenytoin level, though a measure of free phenytoin is more reliable.
© 2020 QxMD Software Inc., all rights reserved. No part of this service may be reproduced in any way without express written consent of QxMD. This information should not be used for the diagnosis or treatment of any health problem or disease. This information is not intended to replace clinical judgment or guide individual patient care in any manner. Click here for full notice and disclaimer.
