Crohn's Disease Activity Index (CDAI)

Assess disease activity in Crohn's disease

Questions

1.Average Number of Liquid or Soft Stools per Day (over 7 days)?

2.Using Diphenoxylate or Loperimide for Diarrhea?

3.Average Abdominal Pain Rating (over 7 days)?

4.General Well Being each Day (over 7 days)?

5.Arthritis or Arthralgia?

6.Iritis or Uveitis?

7.Erythema Nodosum, Pyoderma Gangrenosum or Aphthous Stomatitis?

8.Anal Fissure, Fistula or Abscess?

About

The Crohn's Disease Activity Index (CDAI) is utilized in clinical trials to assess disease activity in Crohn's.

CDAI scores can range from 0 to ~600.

A cut-off value of <150 was selected so that most patients below this threshold would be rated by physicians as 'very well'.

The delineator between active and very severe disease was defined as a cut-off value of 450 points.

CDAI scores of 150–219 has been labelled as mildly active disease and scores of 220–450 as moderately active disease.

CDAI has some limitations, which include:

interobserver variability
ratings of 'general well being' and 'intensity of abdominal pain' are subjective
stool frequency is based on a diary filled in by the patient for 7 days before evaluation which doesn't generally get done in routine clinical practice
it is not accurate in patients with fistulizing and stenosing disease
it is not useful in patients with previous extensive ileo-colonic resections or stoma

References

Best WR.

Predicting the Crohn's disease activity index from the Harvey-Bradshaw Index.

nflammatory Bowel Diseases 2006, 12 (4): 304-10

Best WR, Becktel JM, Singleton JW, Kern F Jr.

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.

Gastroenterology 1976, 70 (3): 439-44

The Crohn's Disease Activity Index (CDAI) calculator is created by QxMD.

Default Units

1. Average Number of Liquid or Soft Stools per Day (over 7 days)?

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