Estimate dialysis duration required for methanol poisoning
In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.
The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.
Hirsch DJ, Jindal KK, Wong P, Fraser AD.
Youssef GM, Hirsch DJ.
McMurray M, Carty D, Toffelmire EB.
Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG.
Watson estimate of total-body water in liters
In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.
The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.
Hirsch DJ, Jindal KK, Wong P, Fraser AD.
Youssef GM, Hirsch DJ.
McMurray M, Carty D, Toffelmire EB.
Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG.
© 2020 QxMD Software Inc., all rights reserved. No part of this service may be reproduced in any way without express written consent of QxMD. This information should not be used for the diagnosis or treatment of any health problem or disease. This information is not intended to replace clinical judgment or guide individual patient care in any manner. Click here for full notice and disclaimer.
