Dialysis Duration Needed for Methanol Ingestion

Estimate dialysis duration required for methanol poisoning

The global unit selector only affects unanswered questions
1.Total Body Water?
2.Initial Methanol Concentration?
3.Dialyzer Urea Clearance?
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1. Total Body Water?

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Watson estimate of total-body water in liters

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In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.

The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.


Hirsch DJ, Jindal KK, Wong P, Fraser AD.

A simple method to estimate the required dialysis time for cases of alcohol poisoning.

Kidney International 2001, 60 (5): 2021-4

Youssef GM, Hirsch DJ.

Validation of a method to predict required dialysis time for cases of methanol and ethylene glycol poisoning.

American Journal of Kidney Diseases 2005, 46 (3): 509-11

McMurray M, Carty D, Toffelmire EB.

Predicting methanol clearance during hemodialysis when direct measurement is not available.

CANNT Journal 2002, 12 (1): 29-38; quiz 32-3

Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG.

Use of pharmacokinetics to determine the duration of dialysis in management of methanol poisoning.

American Journal of Emergency Medicine 1998, 16 (5): 538-40

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