Dialysis Duration Needed for Methanol Ingestion

Estimate dialysis duration required for methanol poisoning

About

In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.

The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.

References

Hirsch DJ, Jindal KK, Wong P, Fraser AD.

Kidney International 2001, 60 (5): 2021-4

Youssef GM, Hirsch DJ.

American Journal of Kidney Diseases 2005, 46 (3): 509-11

McMurray M, Carty D, Toffelmire EB.

CANNT Journal 2002, 12 (1): 29-38; quiz 32-3

Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG.

American Journal of Emergency Medicine 1998, 16 (5): 538-40

The Dialysis Duration Needed for Methanol Ingestion calculator is created by QxMD.
Default Units

1. Total Body Water?

Litres
More Information

Watson estimate of total-body water in liters

0/3 completed

About

In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.

The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.

References

Hirsch DJ, Jindal KK, Wong P, Fraser AD.

Kidney International 2001, 60 (5): 2021-4

Youssef GM, Hirsch DJ.

American Journal of Kidney Diseases 2005, 46 (3): 509-11

McMurray M, Carty D, Toffelmire EB.

CANNT Journal 2002, 12 (1): 29-38; quiz 32-3

Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG.

American Journal of Emergency Medicine 1998, 16 (5): 538-40

The Dialysis Duration Needed for Methanol Ingestion calculator is created by QxMD.
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