Multiple Myeloma Prognosis (R-ISS)

Revised international staging system for myeloma

The global unit selector only affects unanswered questions
3.High-risk Chromosomal Abnormalities?
Created by

1. Β₂-microglobulin?

Created by
0/4 completed

About this Calculator

The Revised International Staging System (R-ISS) includes variables included in the original ISS (serum beta-2 microglobulin and serum albumin), while also including the additional prognostic information obtained from serum LDH and high-risk chromosomal abnormalities detected by interphase fluorescent in situ hybridization (iFISH) after CD138 plasma cell purification.

The revised ISS stages are as follows:

  • Stage I: ISS stage I and standard-risk CA by iFISH and normal LDH
  • Stage II: Not R-ISS stage I or III
  • Stage III: ISS stage III and either high-risk CA by iFISH or high LDH


Palumbo A et al.

Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.

Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2015 September 10, 33 (26): 2863-9

Legal Notices and Disclaimer

© 2020 QxMD Software Inc., all rights reserved. No part of this service may be reproduced in any way without express written consent of QxMD. This information should not be used for the diagnosis or treatment of any health problem or disease. This information is not intended to replace clinical judgment or guide individual patient care in any manner. Click here for full notice and disclaimer.