Diagnosis of Dementia with Lewy Bodies (DLB)

Diagnose patients with dementia with Lewy Bodies based on the 2017 criteria

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1.Does the patient have a progressive cognitive decline which interferes with daily functions (dementia)?
2.Does the patient have fluctuating cognition with pronounced variations in attention and alertness?
3.Does the patient have recurrent visual hallucinations that are typically well-formed and detailed?
4.Does the patient have REM sleep behavior disorder, i.e. a history of violently acting out dreams?
5.Does the patient have at least one cardinal feature of parkinsonism (bradykinesia, rest tremor, or rigidity)?
6.Is there evidence of reduced dopamine transporter uptake in basal ganglia demonstrated by SPECT or PET?
7.Is there evidence of abnormal (low) uptake on iodine-MIBG myocardial scintigraphy?
8.Is there polysomnographic confirmation of REM sleep without atonia?
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1. Does the patient have a progressive cognitive decline which interferes with daily functions (dementia)?

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About this Calculator

The Dementia with Lewy Bodies Consortium released in 2017 a refined set of diagnostic criteria (McKeith et al, 2017). Whereas like other neurodegenerative diseases, the "definite" diagnostic category can only be used after posthumous pathological examination, the "probable" category can be readily used in clinical practice. To be diagnosed with DLB, there is a requirement of the presence of dementia, defined as a progressive cognitive decline which interferes with daily functions. In contrast to Alzheimer's dementia, memory function in DLB is often intact early in the disease course, but there may be profound early impairment of attention, executive dysfunction, and visual-spatial ability.

For a diagnosis of "probable DLB", a patient must have either two "core clinical features" or one "core clinical feature" and one "indicative biomarker". The four core clinical features include fluctuating cognition, visual hallucinations, REM-sleep behaviour disorder, and one cardinal feature of parkinsonism (bradykinesia, rest tremor, or rigidity). The three indicative biomarkers include reduced dopamine uptake on functional nuclear imaging, low uptake on iodine-MIBG myocardial scintigraphy, and confirmation of REM sleep without atonia on polysomnography.

If a patient has only one core clinical feature without an indicative biomarker, or an indicative biomarker without a core clinical feature, only a diagnosis of "possible DLB" can be made.

The Consortium also compiled a list of supportive clinical criteria and supportive biomarkers, but these only provide additional encouragement toward the diagnosis and do not aid in meeting diagnostic criteria. The supportive clinical criteria include: severe sensitivity to antipsychotic agents; postural instability; repeated falls; syncope or other transient episodes of unresponsiveness; severe autonomic dysfunction, e.g., constipation, orthostatic hypotension, urinary incontinence; hypersomnia; hyposmia; hallucinations in other modalities; systematized delusions; apathy, anxiety, and depression. Supportive biomarkers include: relative preservation of medial temporal lobe structures on CT/MRI scan; generalized low uptake on SPECT/PET perfusion/metabolism scan with reduced occipital activity and/or the cingulate island sign on FDG-PET imaging; and prominent posterior slow-wave activity on EEG with periodic fluctuations in the pre-alpha/ theta range.

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