Primary Progressive Multiple Sclerosis: Diagnosis

Diagnose Primary Progressive MS using the 2017 McDonald Criteria

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1.1 year of disability progression (retrospectively or prospectively determined) independent of clinical relapse?
2.One or more T2-hyperintense lesions characteristic of multiple sclerosis in one or more of the following brain regions: periventricular, cortical or juxtacortical, or infratentorial?
3.Two or more T2-hyperintense lesions in the spinal cord?
4.Presence of CSF-specific oligoclonal bands?
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1. 1 year of disability progression (retrospectively or prospectively determined) independent of clinical relapse?

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About this Calculator

The 2017 McDonald Criteria for Diagnosis of MS were compiled by the International Panel on Diagnosis of Multiple Sclerosis. Unlike Relapsing-Remitting MS, patients with Primary Progressive MS experience disability progression independent of clinical relapses. The main revisions from the 2010 McDonald Criteria for PPMS are: symptomatic lesions can now be used to fulfill criteria, and cortical lesions are seen as equivalent to juxtacortical lesions. The requirements for spinal cord lesion and for positive unmatched oligoclonal bands in the CSF remain the same.


Thompson, A., Banwell, B., Barkhof, F., Carroll, W., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M., Fujihara, K., Galetta, S., Hartung, H., Kappos, L., Lublin, F., Marrie, R., Miller, A., Miller, D., Montalban, X., Mowry, E., Sorensen, P., Tintoré, M., Traboulsee, A., Trojano, M., Uitdehaag, B., Vukusic, S., Waubant, E., Weinshenker, B., Reingold, S. and Cohen, J.

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.

Lancet Neurology 2018, 17 (2): 162-173

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