CMML CPSS-Mol

Estimate risk of progression to AML in those with CMML using molecular genetics data

The global unit selector only affects unanswered questions
1.Cytogenetics
2.ASXL1
3.NRAS
4.RUNX1
5.SETBP1
6.BM blasts
7.WBC
8.Transfusions
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1. Cytogenetics

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About this Calculator

The CPSS-Mol is a new CMML-specific prognostic scoring system (CPSS) that incorporates molecular genetic data resulting in a 4-level integrated clinical/pathological/genetic risk stratification tool. This tool was derived from a cohort of European patients, 93% of whom possessed 1 of 38 somatic mutations. Based on multivariable Cox regression analyses, cytogenetic abnormalities and mutations in RUNX1, NRAS, SETBP1, and ASXL1 were independently associated with overall survival (OS). The CPSS-Mol fully retained its ability to risk stratify survival in an independent validation cohort of CMML patients.

References

Contributed By:
  • Matthew Cheung, MD, FRCP(C)
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