Acetaminophen (Paracetamol) Toxicity Assessment

Hours After Ingestion
Acetaminophen Level
  • This calculator is based on data from Rumack and Matthew1. Treatment threshold levels are calculated to be 25% lower than the toxic drug level.
  • This calculator is only appropriate for patients who had a single ingestion of acetaminophen.
  • Drug levels done before the 4 hour point may not represent the true peak of absorption.
  1. Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics. 1975 Jun;55(6):871-6.
  2. Buckley NA, Whyte IM, O'Connell DL, et. al. Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose. J Toxicol Clin Toxicol. 1999;37(6):753-7.
  3. Vale JA, Proudfoot AT. Paracetamol (acetaminophen) poisoning. Lancet. 1995 Aug 26;346(8974):547-52. Review.
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