Glucosamine Sulfate (Herb/Suppl)

Brand and Other Names:2-Aminodeoxyglucose sulfate, amino monosaccharide, more...chitosamine, G6S, glucose6 phosphate, glucose6 sulfate, sulfated monosaccharide, 2-amino-2-deoxy-beta-D-glucopyranose

Suggested Dosing

Osteoarthritis, TMJ Arthritis

500 mg PO TID OR

1500 mg PO qDay

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Suggested Uses

Relief of symptoms of osteoarthritis, temporomandibular joint arthritis

Efficacy

Slower-acting than ibuprofen, but comparable effectiveness after 6-12 weeks of treatment

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Adverse Effects

Frequency Not Defined

Possible poor glycemic control in diabetics; monitor blood glucose

Increased intraocular pressure (see Cautions)

Constipation

Diarrhea

Drowsiness

Headache

Heartburn

Hyperinsulinemia

Nausea

Skin reactions

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Warnings

Contraindications

None reported

Cautions

Diabetes mellitus, hyperlipidemia, hypertension, hypersensitivity to seafood (derived from shellfish)

Increased intraocular pressure observed in controlled clinical trial (JAMA Ophthal May 23, 2013; published online)

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Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Intermediate in glycosaminoglycan synthesis

Absorbed: glucosamine sulfate better absorbed than other forms of glucosamine, or chondroitin

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.