Indication-specific dosing for (5-HTP), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections 5-htp
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

Depression

150-300 mg PO qDay

Primary Fibromyalgia Syndrome

100 mg PO TID for up to 1 month

Tetrahydrobiopterin Deficiency (Orphan)

Orphan indication sponsor

Watson Laboratories, Inc; 311 Bonnie Circle, P.O. Box 1900; Corona, CA 91718-1900

Suggested Uses

Anxiety, cerebellar ataxia, depression, fibromyalgia syndrome (primary), headaches (migraine/tension), myoclonus (intention/post-anoxic), Ramsey-Hunt syndrome, seizure disorder (adjunctive therapy), sleep disorders

Efficacy

Possibly effective for depression and fibromyalgia

Interaction Checker

Enter a drug name and 5-htp

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Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

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Contraindicated (0)

Serious - Use Alternative (5)

isocarboxazid
isocarboxazid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
linezolid
linezolid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
methylene blue
methylene blue and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
phenelzine
phenelzine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
tranylcypromine
tranylcypromine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.

Monitor Closely (55)

almotriptan
almotriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
amitriptyline
amitriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
amoxapine
amoxapine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
buspirone
5-HTP and buspirone both increase serotonin levels. Modify Therapy/Monitor Closely.
citalopram
citalopram and 5-HTP both increase serotonin levels. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.
clomipramine
clomipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
cocaine topical
5-HTP and cocaine topical both increase serotonin levels. Use Caution/Monitor.
cyproheptadine
cyproheptadine decreases effects of 5-HTP by pharmacodynamic antagonism. Use Caution/Monitor. Cyproheptadine may diminish the serotonergic effect of 5-HTP.
desipramine
desipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
dexfenfluramine
5-HTP and dexfenfluramine both increase serotonin levels. Use Caution/Monitor.
dextroamphetamine
5-HTP and dextroamphetamine both increase serotonin levels. Use Caution/Monitor.
dextromethorphan
5-HTP and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
dihydroergotamine
5-HTP and dihydroergotamine both increase serotonin levels. Use Caution/Monitor.
dihydroergotamine intranasal
5-HTP and dihydroergotamine intranasal both increase serotonin levels. Use Caution/Monitor.
doxepin
doxepin and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
duloxetine
duloxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
eletriptan
eletriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
ergotamine
5-HTP and ergotamine both increase serotonin levels. Use Caution/Monitor.
escitalopram
escitalopram and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
fenfluramine
5-HTP and fenfluramine both increase serotonin levels. Use Caution/Monitor.
fluoxetine
fluoxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
fluvoxamine
fluvoxamine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
frovatriptan
frovatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
imipramine
imipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
isoniazid
5-HTP and isoniazid both increase serotonin levels. Use Caution/Monitor.
L-tryptophan
5-HTP and L-tryptophan both increase serotonin levels. Use Caution/Monitor.
levomilnacipran
levomilnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
lithium
5-HTP and lithium both increase serotonin levels. Use Caution/Monitor.
lofepramine
lofepramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
lsd
5-HTP and lsd both increase serotonin levels. Use Caution/Monitor.
maprotiline
maprotiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
meperidine
5-HTP and meperidine both increase serotonin levels. Modify Therapy/Monitor Closely.
milnacipran
milnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
mirtazapine
5-HTP and mirtazapine both increase serotonin levels. Use Caution/Monitor.
morphine
5-HTP and morphine both increase serotonin levels. Use Caution/Monitor.
naratriptan
naratriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
nefazodone
nefazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
nortriptyline
nortriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
paroxetine
paroxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
pentazocine
5-HTP and pentazocine both increase serotonin levels. Use Caution/Monitor.
protriptyline
protriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
rasagiline
rasagiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
rizatriptan
rizatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
SAMe
5-HTP and SAMe both increase serotonin levels. Use Caution/Monitor.
selegiline
selegiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
selegiline transdermal
selegiline transdermal and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
sertraline
sertraline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
St John's Wort
5-HTP and St John's Wort both increase serotonin levels. Modify Therapy/Monitor Closely.
sumatriptan
sumatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
sumatriptan intranasal
sumatriptan intranasal and 5-HTP both increase serotonin levels. Use Caution/Monitor.
tramadol
5-HTP and tramadol both increase serotonin levels. Use Caution/Monitor.
trazodone
trazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
trimipramine
trimipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
venlafaxine
venlafaxine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
zolmitriptan
zolmitriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

Minor (0)

almotriptan
Monitor Closely (1)almotriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
amitriptyline
Monitor Closely (1)amitriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
amoxapine
Monitor Closely (1)amoxapine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
buspirone
Monitor Closely (1)5-HTP and buspirone both increase serotonin levels. Modify Therapy/Monitor Closely.
citalopram
Monitor Closely (1)citalopram and 5-HTP both increase serotonin levels. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.
clomipramine
Monitor Closely (1)clomipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
cocaine topical
Monitor Closely (1)5-HTP and cocaine topical both increase serotonin levels. Use Caution/Monitor.
cyproheptadine
Monitor Closely (1)cyproheptadine decreases effects of 5-HTP by pharmacodynamic antagonism. Use Caution/Monitor. Cyproheptadine may diminish the serotonergic effect of 5-HTP.
desipramine
Monitor Closely (1)desipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
dexfenfluramine
Monitor Closely (1)5-HTP and dexfenfluramine both increase serotonin levels. Use Caution/Monitor.
dextroamphetamine
Monitor Closely (1)5-HTP and dextroamphetamine both increase serotonin levels. Use Caution/Monitor.
dextromethorphan
Monitor Closely (1)5-HTP and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
dihydroergotamine
Monitor Closely (1)5-HTP and dihydroergotamine both increase serotonin levels. Use Caution/Monitor.
dihydroergotamine intranasal
Monitor Closely (1)5-HTP and dihydroergotamine intranasal both increase serotonin levels. Use Caution/Monitor.
doxepin
Monitor Closely (1)doxepin and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
duloxetine
Monitor Closely (1)duloxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
eletriptan
Monitor Closely (1)eletriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
ergotamine
Monitor Closely (1)5-HTP and ergotamine both increase serotonin levels. Use Caution/Monitor.
escitalopram
Monitor Closely (1)escitalopram and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
fenfluramine
Monitor Closely (1)5-HTP and fenfluramine both increase serotonin levels. Use Caution/Monitor.
fluoxetine
Monitor Closely (1)fluoxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
fluvoxamine
Monitor Closely (1)fluvoxamine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
frovatriptan
Monitor Closely (1)frovatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
imipramine
Monitor Closely (1)imipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
isocarboxazid
Serious - Use Alternative (1)isocarboxazid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
isoniazid
Monitor Closely (1)5-HTP and isoniazid both increase serotonin levels. Use Caution/Monitor.
L-tryptophan
Monitor Closely (1)5-HTP and L-tryptophan both increase serotonin levels. Use Caution/Monitor.
levomilnacipran
Monitor Closely (1)levomilnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
linezolid
Serious - Use Alternative (1)linezolid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
lithium
Monitor Closely (1)5-HTP and lithium both increase serotonin levels. Use Caution/Monitor.
lofepramine
Monitor Closely (1)lofepramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
lsd
Monitor Closely (1)5-HTP and lsd both increase serotonin levels. Use Caution/Monitor.
maprotiline
Monitor Closely (1)maprotiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
meperidine
Monitor Closely (1)5-HTP and meperidine both increase serotonin levels. Modify Therapy/Monitor Closely.
methylene blue
Serious - Use Alternative (1)methylene blue and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
milnacipran
Monitor Closely (1)milnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
mirtazapine
Monitor Closely (1)5-HTP and mirtazapine both increase serotonin levels. Use Caution/Monitor.
morphine
Monitor Closely (1)5-HTP and morphine both increase serotonin levels. Use Caution/Monitor.
naratriptan
Monitor Closely (1)naratriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
nefazodone
Monitor Closely (1)nefazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
nortriptyline
Monitor Closely (1)nortriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
paroxetine
Monitor Closely (1)paroxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
pentazocine
Monitor Closely (1)5-HTP and pentazocine both increase serotonin levels. Use Caution/Monitor.
phenelzine
Serious - Use Alternative (1)phenelzine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
protriptyline
Monitor Closely (1)protriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
rasagiline
Monitor Closely (1)rasagiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
rizatriptan
Monitor Closely (1)rizatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
SAMe
Monitor Closely (1)5-HTP and SAMe both increase serotonin levels. Use Caution/Monitor.
selegiline
Monitor Closely (1)selegiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
selegiline transdermal
Monitor Closely (1)selegiline transdermal and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
sertraline
Monitor Closely (1)sertraline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
St John's Wort
Monitor Closely (1)5-HTP and St John's Wort both increase serotonin levels. Modify Therapy/Monitor Closely.
sumatriptan
Monitor Closely (1)sumatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
sumatriptan intranasal
Monitor Closely (1)sumatriptan intranasal and 5-HTP both increase serotonin levels. Use Caution/Monitor.
tramadol
Monitor Closely (1)5-HTP and tramadol both increase serotonin levels. Use Caution/Monitor.
tranylcypromine
Serious - Use Alternative (1)tranylcypromine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone
Monitor Closely (1)trazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
trimipramine
Monitor Closely (1)trimipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
venlafaxine
Monitor Closely (1)venlafaxine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
zolmitriptan
Monitor Closely (1)zolmitriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

Adverse Effects

Anorexia, diarrhea, eosinophilia myalgia syndrome, eosinophilia (asymptomatic), flatulence, heartburn, nausea/vomiting, stomach pain

Contraindications

None reported

Cautions

Down syndrome, peptic ulcers, platelet disorders, renal disease

Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

5-hydroxytryptophan is precursor of serotonin (5-hydroxytryptamine); boosts serotonin levels in CNS

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections 5-htp
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

5-htp (Herb/Suppl)