5-htp (Herb/Suppl)

Brand and Other Names:5Hydroxytryptophan, Griffonia simplicifolia, more...hydroxytryptophan, L5 hydroxytryptophan, L-5-HTP, oxitriptan, Tript-OH
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Suggested Dosing

Depression

150-300 mg PO qDay

Primary Fibromyalgia Syndrome

100 mg PO TID for up to 1 month

Tetrahydrobiopterin Deficiency (Orphan)

Orphan indication sponsor

  • Watson Laboratories, Inc; 311 Bonnie Circle, P.O. Box 1900; Corona, CA 91718-1900
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Suggested Uses

Anxiety, cerebellar ataxia, depression, fibromyalgia syndrome (primary), headaches (migraine/tension), myoclonus (intention/post-anoxic), Ramsey-Hunt syndrome, seizure disorder (adjunctive therapy), sleep disorders

Efficacy

Possibly effective for depression and fibromyalgia

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Interactions

Interaction Checker

and 5-htp

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Anorexia, diarrhea, eosinophilia myalgia syndrome, eosinophilia (asymptomatic), flatulence, heartburn, nausea/vomiting, stomach pain

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            Warnings

            Contraindications

            None reported

            Cautions

            Down syndrome, peptic ulcers, platelet disorders, renal disease

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            Pregnancy & Lactation

            Pregnancy Category: N/A

            Lactation: N/A

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            5-hydroxytryptophan is precursor of serotonin (5-hydroxytryptamine); boosts serotonin levels in CNS

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.