Suggested Dosing
Depression
150-300 mg PO qDay
Primary Fibromyalgia Syndrome
100 mg PO TID for up to 1 month
Tetrahydrobiopterin Deficiency (Orphan)
Orphan indication sponsor
- Watson Laboratories, Inc; 311 Bonnie Circle, P.O. Box 1900; Corona, CA 91718-1900
Suggested Uses
Anxiety, cerebellar ataxia, depression, fibromyalgia syndrome (primary), headaches (migraine/tension), myoclonus (intention/post-anoxic), Ramsey-Hunt syndrome, seizure disorder (adjunctive therapy), sleep disorders
Efficacy
Possibly effective for depression and fibromyalgia
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (5)
- isocarboxazid
isocarboxazid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
- linezolid
linezolid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
- methylene blue
methylene blue and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
- phenelzine
phenelzine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
- tranylcypromine
tranylcypromine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.
Monitor Closely (55)
- almotriptan
almotriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
- amitriptyline
amitriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- amoxapine
amoxapine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- buspirone
5-HTP and buspirone both increase serotonin levels. Modify Therapy/Monitor Closely.
- citalopram
citalopram and 5-HTP both increase serotonin levels. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.
- clomipramine
clomipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- cocaine topical
5-HTP and cocaine topical both increase serotonin levels. Use Caution/Monitor.
- cyproheptadine
cyproheptadine decreases effects of 5-HTP by pharmacodynamic antagonism. Use Caution/Monitor. Cyproheptadine may diminish the serotonergic effect of 5-HTP.
- desipramine
desipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- dexfenfluramine
5-HTP and dexfenfluramine both increase serotonin levels. Use Caution/Monitor.
- dextroamphetamine
5-HTP and dextroamphetamine both increase serotonin levels. Use Caution/Monitor.
- dextromethorphan
5-HTP and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
- dihydroergotamine
5-HTP and dihydroergotamine both increase serotonin levels. Use Caution/Monitor.
- dihydroergotamine intranasal
5-HTP and dihydroergotamine intranasal both increase serotonin levels. Use Caution/Monitor.
- doxepin
doxepin and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- duloxetine
duloxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- eletriptan
eletriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
- ergotamine
5-HTP and ergotamine both increase serotonin levels. Use Caution/Monitor.
- escitalopram
escitalopram and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- fenfluramine
5-HTP and fenfluramine both increase serotonin levels. Use Caution/Monitor.
- fluoxetine
fluoxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- fluvoxamine
fluvoxamine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- frovatriptan
frovatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
- imipramine
imipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- isoniazid
5-HTP and isoniazid both increase serotonin levels. Use Caution/Monitor.
- L-tryptophan
5-HTP and L-tryptophan both increase serotonin levels. Use Caution/Monitor.
- levomilnacipran
levomilnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- lithium
5-HTP and lithium both increase serotonin levels. Use Caution/Monitor.
- lofepramine
lofepramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- lsd
5-HTP and lsd both increase serotonin levels. Use Caution/Monitor.
- maprotiline
maprotiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- meperidine
5-HTP and meperidine both increase serotonin levels. Modify Therapy/Monitor Closely.
- milnacipran
milnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- mirtazapine
5-HTP and mirtazapine both increase serotonin levels. Use Caution/Monitor.
- morphine
5-HTP and morphine both increase serotonin levels. Use Caution/Monitor.
- naratriptan
naratriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
- nefazodone
nefazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- nortriptyline
nortriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- paroxetine
paroxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- pentazocine
5-HTP and pentazocine both increase serotonin levels. Use Caution/Monitor.
- protriptyline
protriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- rasagiline
rasagiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- rizatriptan
rizatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
- SAMe
5-HTP and SAMe both increase serotonin levels. Use Caution/Monitor.
- selegiline
selegiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- selegiline transdermal
selegiline transdermal and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- sertraline
sertraline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- St John's Wort
5-HTP and St John's Wort both increase serotonin levels. Modify Therapy/Monitor Closely.
- sumatriptan
sumatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
- sumatriptan intranasal
sumatriptan intranasal and 5-HTP both increase serotonin levels. Use Caution/Monitor.
- tramadol
5-HTP and tramadol both increase serotonin levels. Use Caution/Monitor.
- trazodone
trazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- trimipramine
trimipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- venlafaxine
venlafaxine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
- zolmitriptan
zolmitriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.
Minor (0)
Adverse Effects
Anorexia, diarrhea, eosinophilia myalgia syndrome, eosinophilia (asymptomatic), flatulence, heartburn, nausea/vomiting, stomach pain
Warnings
Contraindications
None reported
Cautions
Down syndrome, peptic ulcers, platelet disorders, renal disease
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
5-hydroxytryptophan is precursor of serotonin (5-hydroxytryptamine); boosts serotonin levels in CNS