5-htp (Herb/Suppl)

Brand and Other Names:5Hydroxytryptophan, Griffonia simplicifolia, more...hydroxytryptophan, L5 hydroxytryptophan, L-5-HTP, oxitriptan, Tript-OH
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Suggested Dosing

Depression

150-300 mg PO qDay

Primary Fibromyalgia Syndrome

100 mg PO TID for up to 1 month

Tetrahydrobiopterin Deficiency (Orphan)

Orphan indication sponsor

  • Watson Laboratories, Inc; 311 Bonnie Circle, P.O. Box 1900; Corona, CA 91718-1900
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Suggested Uses

Anxiety, cerebellar ataxia, depression, fibromyalgia syndrome (primary), headaches (migraine/tension), myoclonus (intention/post-anoxic), Ramsey-Hunt syndrome, seizure disorder (adjunctive therapy), sleep disorders

Efficacy

Possibly effective for depression and fibromyalgia

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Interactions

Interaction Checker

and 5-htp

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            Contraindicated (0)

              Serious - Use Alternative (5)

              • isocarboxazid

                isocarboxazid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.

              • linezolid

                linezolid and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.

              • methylene blue

                methylene blue and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.

              • phenelzine

                phenelzine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.

              • tranylcypromine

                tranylcypromine and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug.

              Monitor Closely (55)

              • almotriptan

                almotriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              • amitriptyline

                amitriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • amoxapine

                amoxapine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • buspirone

                5-HTP and buspirone both increase serotonin levels. Modify Therapy/Monitor Closely.

              • citalopram

                citalopram and 5-HTP both increase serotonin levels. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.

              • clomipramine

                clomipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • cocaine

                5-HTP and cocaine both increase serotonin levels. Use Caution/Monitor.

              • cyproheptadine

                cyproheptadine decreases effects of 5-HTP by pharmacodynamic antagonism. Use Caution/Monitor. Cyproheptadine may diminish the serotonergic effect of 5-HTP.

              • desipramine

                desipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • dexfenfluramine

                5-HTP and dexfenfluramine both increase serotonin levels. Use Caution/Monitor.

              • dextroamphetamine

                5-HTP and dextroamphetamine both increase serotonin levels. Use Caution/Monitor.

              • dextromethorphan

                5-HTP and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.

              • dihydroergotamine

                5-HTP and dihydroergotamine both increase serotonin levels. Use Caution/Monitor.

              • dihydroergotamine intranasal

                5-HTP and dihydroergotamine intranasal both increase serotonin levels. Use Caution/Monitor.

              • doxepin

                doxepin and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • duloxetine

                duloxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • eletriptan

                eletriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              • ergotamine

                5-HTP and ergotamine both increase serotonin levels. Use Caution/Monitor.

              • escitalopram

                escitalopram and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • fenfluramine

                5-HTP and fenfluramine both increase serotonin levels. Use Caution/Monitor.

              • fluoxetine

                fluoxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • fluvoxamine

                fluvoxamine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • frovatriptan

                frovatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              • imipramine

                imipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • isoniazid

                5-HTP and isoniazid both increase serotonin levels. Use Caution/Monitor.

              • L-tryptophan

                5-HTP and L-tryptophan both increase serotonin levels. Use Caution/Monitor.

              • levomilnacipran

                levomilnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • lithium

                5-HTP and lithium both increase serotonin levels. Use Caution/Monitor.

              • lofepramine

                lofepramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • lsd

                5-HTP and lsd both increase serotonin levels. Use Caution/Monitor.

              • maprotiline

                maprotiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • meperidine

                5-HTP and meperidine both increase serotonin levels. Modify Therapy/Monitor Closely.

              • milnacipran

                milnacipran and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • mirtazapine

                5-HTP and mirtazapine both increase serotonin levels. Use Caution/Monitor.

              • morphine

                5-HTP and morphine both increase serotonin levels. Use Caution/Monitor.

              • naratriptan

                naratriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              • nefazodone

                nefazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • nortriptyline

                nortriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • paroxetine

                paroxetine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • pentazocine

                5-HTP and pentazocine both increase serotonin levels. Use Caution/Monitor.

              • protriptyline

                protriptyline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • rasagiline

                rasagiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • rizatriptan

                rizatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              • SAMe

                5-HTP and SAMe both increase serotonin levels. Use Caution/Monitor.

              • selegiline

                selegiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • selegiline transdermal

                selegiline transdermal and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • sertraline

                sertraline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • St John's Wort

                5-HTP and St John's Wort both increase serotonin levels. Modify Therapy/Monitor Closely.

              • sumatriptan

                sumatriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              • sumatriptan intranasal

                sumatriptan intranasal and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              • tramadol

                5-HTP and tramadol both increase serotonin levels. Use Caution/Monitor.

              • trazodone

                trazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • trimipramine

                trimipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • venlafaxine

                venlafaxine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.

              • zolmitriptan

                zolmitriptan and 5-HTP both increase serotonin levels. Use Caution/Monitor.

              Minor (0)

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                Adverse Effects

                Anorexia, diarrhea, eosinophilia myalgia syndrome, eosinophilia (asymptomatic), flatulence, heartburn, nausea/vomiting, stomach pain

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                Warnings

                Contraindications

                None reported

                Cautions

                Down syndrome, peptic ulcers, platelet disorders, renal disease

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                5-hydroxytryptophan is precursor of serotonin (5-hydroxytryptamine); boosts serotonin levels in CNS

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.