Dosing & Uses
AdultPediatric
Dosage Forms & Strengths
powder for solution
- 15g/sachet (250mOsm/sachet)
Hyponatremia
Consider use as second line treatment of moderate or profound hyponatremia (first line treatment is fluid restriction)
0.25-0.5 g/kg/day PO (European SIAD guidelines)
Dosage range
- 45.5 kg: 11-22.75 g/day
- 54.5 kg: 13.6-27.2 g/day
- 63.6 kg: 15.9-31.8 g/day
- 72.7 kg: 18.1-36.3 g/day
- 81.8 kg: 20.4-40.9 g/day
- 90.9 kg: 22.7-45.4 g/day
Dosing Considerations
Do not use for patients with hypovolemic hyponatremia, hyponatremia associated with adrenal insufficiency, or hyperammonemia
Safety and efficacy not established
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Warnings
Contraindications
Hypovolemic hyponatremia
Hyponatremia associated with adrenal insufficiency
Hyperammonemia
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Pharmacology
Mechanism of Action
Medical food; for use under medical supervision
Urea normalizes serum sodium by inducing osmotic excretion of free water without associated electrolyte depletion
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Administration
Oral Administration
Mix 1 sachet (15 grams) in 3-4 ounces of water or juice and drink
Storage
Store in cool, dry place
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Images
No images available for this drug.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
