triamcinolone acetonide injectable suspension (Rx)

Brand and Other Names:Kenalog-10, Kenalog-40
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Dosing & Uses


Dosage Forms & Strengths

injectable suspension

  • 10mg/mL (Kenalog-10; intralesional or intra-articular administration)
  • 40mg/mL (Kenalog-40; IM or intra-articular administration)

Rheumatic or Arthritic Disorders

Treatment of rheumatic or arthritic disorders

Kenalog-40: 60 mg IM every 6 weeks; may be supplemented by additional 20-100 mg IM PRN

Intra-articular/intrasynovial/soft-tissue injection (Kenalog-40): Large joints, 15-40 mg; small joints/tendon sheath inflammation, 2.5-10 mg

Intra-articular injection (Kenalog-10): Large joints, 5-15 mg; small joints, 2.5-5 mg; single injections into several joints, up to a total of 20 mg or more have been given


Indicated for treatment of steroid-responsive dermatoses

Intralesional injection (Kenalog-10): 1 mg per injection site 1 or more times weekly; not to exceed 30 mg/day

Kenalog-10: Initial dose varies intralesional injection depending on specific disease and lesion being treated; may be repeated at weekly or less frequent intervals; multiple sites may be injected if they are ≥1 cm apart

Inflammatory & Allergic Systemic Conditions

Kenalog-40: 60 mg IM single injection; adjust dose to a range of 40-80 mg

For patients with hay fever or pollen asthma who are not responding to pollen administration and other conventional therapy, a single injection of 40-100 mg per season may be given

Multiple Sclerosis

Kenalog-40: 160 mg IM qDay for 1 week, followed by 64 mg every other day for 1 month

Dosage Forms & Strengths

injectable suspension (triamcinolone acetonide)

  • 10mg/mL (Kenalog-10; intralesional or intra-articular administration)
  • 40mg/mL (Kenalog-40; IM or intra-articular administration)

Rheumatic or Arthritic Disorders

Treatment of rheumatic or arthritic disorders

Neonates: Not for use in neonates (contains benzyl alcohol); see Cautions

6-12 years: 0.03-0.2 mg/kg IM every 1-7 days

>12 years: 60 mg IM every 6 weeks; may be supplemented by additional 20-100 mg IM PRN

>12 years, intralesional injection (10 mg/mL suspension): 1 mg per injection site 1 or more times weekly; not to exceed 30 mg/day

Inflammatory & Allergic Systemic Conditions

Initial dose of triamcinolone may vary depending on specific disease entity being treated

0.11-1.6 mg/kg/day IM divided q3-4hr  

Also, see Cautions and Administration



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            Adverse Effects


            Joint swelling (3%)

            Contusions (2%)

            Sinusitis (2%)

            Cough (2%)

            Frequency Not Defined



            Cardiac enlargement

            Circulatory collapse

            Adrenal suppression



            Increased intracranial pressure






            Joint tissues damage

            Lupus erythematosus-like lesions



            Delayed wound healing

            Diabetes mellitus




            Increased appetite


            Tendon rupture




            Pseudotumor cerebri (on withdrawal)



            Postmarketing Report

            Postmenopausal vaginal hemorrhage




            Systemic fungal infection, except as intra-articular injection for localized joint conditions

            Documented hypersensitivity to corticosteroids or any components of the product

            IM corticosteroids contraindicated for idiopathic thrombocytopenic purpura (ITP)

            Triamcinolone diacetate injectable suspension contraindicated for intrathecal administration

            Cerebral malaria

            Benzyl alcohol-containing formulations associated with potentially fatal "gasping syndrome" in premature newborns

            Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids


            Triamcinolone acetonide injectable suspension is for intra-articular or intralesional use only, not for IV, SC, intraocular, epidural, or IT use

            Triamcinolone acetonide suspensions contain benzyl alcohol; exposure to excessive amounts of benzyl alcohol has been associated with toxicity (hypotension, metabolic acidosis), particularly in neonates, and an increased incidence of kernicterus, particularly in small preterm infants

            Rare instances of anaphylaxis have been reported in individuals receiving triamcinolone acetonide injection, regardless of the route of administration (see Contraindications)

            Corticosteroids can produce reversible hypothalamic-pituitary-adrenal axis suppression, potential for adrenal sufficiency after withdrawal of treatment, which may persist for months; institute corticosteroid replacement therapy in situations of stress (eg, stress) during that period

            Corticosteroids may increase blood pressure, salt and water retention, and potassium excretion; monitor for signs or symptoms (eg, edema, weight gain, and imbalance in serum electrolytes) in congestive heart failure or hypertensive patients

            Corticosteroid may be associated with development or exacerbation of increased intraocular pressure; monitor patients with elevated intraocular pressure for potential treatment adjustment

            Corticosteroids decrease bone formation and increase bone resorption through their effect on calcium regulation and inhibition of osteoblast function

            Risk of behavioral and mood disturbances may be associated with corticosteroid use; advise patients and/or caregivers to immediately report any new or worsening behavior or mood disturbances

            Atrophy at injection site reported; avoid IM deltoid injection; subcutaneous atrophy may occur

            Prolonged use of corticosteroids may increase incidence of secondary infection, cause activation of latent infections, mask acute infection, prolong or exacerbate viral infections, or limit response to killed or inactivated vaccines; avoid exposure to chickenpox or measles; should not be used to treat ocular herpes simplex, cerebral malaria, fungal infections, or viral hepatitis; closely monitor patients with latent tuberculosis (TB) and/or reactivity; not for use in active TB; prior to initiating corticosteroid therapy, amebiasis should be rulsed out in any patient with recent travel to tropic climates or unexplained diarrhea; use caution in patients with Strongylides infections

            Prolonged treatment with corticosteroids associated with development of Kaposi sarcoma; consider discontinuing therapy

            Acute myopathy reported with high-dose corticosteroids when given concomitantly with neuromuscular blocking agents or patients with neuromuscular transmission disorders; may involve ocular and/or respiratory muscles; monitor creatinine kinase

            Psychiatric disturbances associated with corticosteroid use, including insomnia, mood swings, euphoria, and personality changes; preexisting psychiatric conditions may be exacerbated by corticosteroid use

            Septic arthritis may occur as a complication to intra-articular or soft tissues manifestation; institute appropriate antibacterial therapy as necessary

            Use with caution in patients with gastrointestinal diseases due to perforation risk

            Not for management of head injury; increased mortality reported in patients receiving high-dose IV-methylprednisolone to manage head injuries

            Use caution in patients with myasthenia gravis; exacerbation of symptoms may occur

            Changes in thyroid status may necessitate dosage adjustments; metabolic clearance of corticosteroids increases in hyperthyroid patients and decreases in hypothyroid ones

            Use caution in patients with history of seizure disorder; seizures reported with adrenal crisis

            Use cautioni in patients with renal impairment; fluid retention may occur

            Use with caution in patients with osteoporosis; increased bone loss and osteoporotic fractures reported with high doses and/or long-term use of corticosteroids

            Epidural injection

            • Serious neurologic events, some resulting in death, have been reported with epidural injection
            • Specific events reported include, but are not limited to, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke
            • These serious neurologic events have been reported with and without use of fluoroscopy
            • Safety and effectiveness of epidural administration of corticosteroids have not been established, and corticosteroids are not approved for this use

            Drug interactions overview

            • Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression
            • Concomitant with potassium-depleting agents (ie, amphotericin B, diuretics), observe for development of hypokalemia
            • Cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure
            • Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance
            • Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis; if possible, withdraw anticholinesterase agents at least 24 hours before initiating corticosteroid therapy
            • Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin; monitor INR
            • Corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required
            • Cholestyramine may increase the clearance of corticosteroids
            • Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently; convulsions have been reported with this concurrent use
            • Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect
            • Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia
            • Corticosteroids may suppress reactions to allergy related skin tests
            • Aspirin
              • Concomitant use of aspirin (or other nonsteroidal anti-inflammatory drugs) and corticosteroids increases the risk of gastrointestinal side effects
              • Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia
              • Clearance of salicylates may be increased with concurrent use of corticosteroids
            • CYP3A4 inducers/inhibitors
              • Concomitant use with CYP3A4 inducers may enhance the metabolism of corticosteroids and may require an increase in the corticosteroid dose
              • Ketoconazole, a strong CYP3A4 inhibitor, has been reported to decrease the metabolism of certain corticosteroids by up to 60% leading to an increased risk of corticosteroid side effects
            • Vaccines
              • Prolonged corticosteroid therapy may cause a diminished response to toxoids, live, or inactivated vaccines due to inhibition of antibody response; possibly potentiate the replication of some organisms contained in live attenuated vaccines
              • If possible, defer routine administration of vaccines or toxoids until corticosteroid therapy is discontinued

            Pregnancy & Lactation


            There are no data regarding the use of triamcinolone acetonide in pregnant women to inform a drug associated risk of adverse developmental outcomes

            In animal reproductive studies from published literature, pregnant mice, rats, rabbits, or primates administered triamcinolone acetonide during organogenesis period at doses that produced exposures less than the maximum recommended human dose (MRHD) caused resorptions, decreased fetal body weight, craniofacial and/or other abnormalities such as omphalocele

            Corticosteroids may result in menstrual pattern irregularities (eg, deviations in timing, duration of menses, increased/decreased blood loss)


            There are no available data on the presence of triamcinolone acetonide in either human or animal milk, the effects on the breastfed infant, or the effects on milk production

            Corticosteroids have been detected in human milk and may suppress milk production

            Caution should be exercised when corticosteroids are administered to a nursing woman

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.



            Mechanism of Action

            Potent glucocorticoid with minimal to no mineralocorticoid activity

            Controls or prevents inflammation by suppressing migration of polymorphonuclear leukocytes and fibroblasts and reversing capillary permeability

            Suppresses immune system by reducing volume and activity of lymphatic system


            Bioavailability: Complete with intra-articular injection

            Duration: 8-12 hr (PO)


            Protein bound: 68%

            Vd: 99.5 L


            Metabolized in liver


            Half-life: Plasma, 2-3 hr; biologic, 18-36 hr

            Renal clearance: 9.5 mL/min

            Excretion: Urine (40%), feces (60%)



            IM, Intralesional, or Intra-articular Administration

            Kenalog injection

            • Systemic: Deep IM administration into the gluteal muscle
            • Local: Intra-articular or intralesional administration only
            • With intra-articular administration, prior use of a local anesthetic may often be desirable
            • When administered intralesionally, inject directly into the lesion (ie, intradermally or subcutaneously); one mL syringes with a 23- to 25-gauge needle are preferable for intralesional injections


            Kenalog-10 and Kenalog 40: Store at 20-25°C (68-77°F); avoid freezing





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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
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