docosanol cream (OTC)

Brand and Other Names:Abreva
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream

  • 10%

Cold sore/fever blister

Wash hands before using

Apply topically to cover all lesions 5 times/day; rub gently but completely

Dosage Forms & Strengths

cream

  • 10%

Cold sore/fever blister

< 12 years

  • Safety & efficacy not established; ask a doctor

>12 years

  • Wash hands before using
  • Apply topically to cover all lesions 5 times/day; rub gently but completely
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Adverse Effects

1-10%

Headache

Application site reaction (e.g., burning, stinging)

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Warnings

Contraindications

Hypersensitivity

Cautions

Apply only to affected areas

Not for use in or near eyes

Avoid applying inside mouth

Sharing product with other people may spread infection

Stop using product if cold sore gets worse or not healed within 10 days

If swallowed by child contact poison control right away

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Pregnancy & Lactation

Pregnancy Category: NA

Lactation: Not studied

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Exerts its antiviral effect on HSV by inhibiting fusion of the virus envelope with host cell plasma membranes, resulting in inhibition of viral entry into cells and subsequent viral replication

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Images

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.