Suggested Dosing
0.6-3 g dried root PO qDay
400 mg standardized extract PO qDay/TID
Therapy for 30-60 days, followed by 2-3 weeks off
Extract standardized to 0.3% eleutheroside E
Suggested Uses
Adaptogen: adapt to internal/external stressors, fight fatigue, increase stamina
Reduce severity/duration of herpes simplex type II infections
Arterosclerosis, athletic/work performance enhancement, chronic fatigue syndrome, craniocerebral trauma, diabetes, fibromyalgia, hypertension/hypotension, immunostimulant, neuroses
Efficacy
Possibly effective for common cold and herpes simplex virus type 2
Possibly ineffective for athletic performance
Insufficient reliable evidence on chronic fatigue syndrome, cognitive performance, heart disease, influenza, ischemic stroke and quality of life
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (69)
- aceclofenac
aceclofenac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- acemetacin
acemetacin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- agrimony
agrimony and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- alfalfa
alfalfa and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- alteplase
alteplase and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- American ginseng
American ginseng and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- antithrombin alfa
antithrombin alfa and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- antithrombin III
antithrombin III and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- argatroban
argatroban and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- aspirin
aspirin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- aspirin rectal
aspirin rectal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- bemiparin
bemiparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- bivalirudin
bivalirudin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- celecoxib
celecoxib and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- choline magnesium trisalicylate
choline magnesium trisalicylate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- cinnamon
cinnamon and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- cordyceps
cordyceps and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- dabigatran
dabigatran and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- dalteparin
dalteparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- diclofenac
diclofenac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- diflunisal
diflunisal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- dong quai
dong quai and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- enoxaparin
enoxaparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- epoprostenol
epoprostenol and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- etodolac
etodolac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- fennel
fennel and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- fenoprofen
fenoprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- feverfew
feverfew and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- flurbiprofen
flurbiprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- fondaparinux
fondaparinux and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- forskolin
forskolin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- garlic
garlic and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- ginger
ginger and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- ginkgo biloba
ginkgo biloba and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- heparin
heparin and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- horse chestnut seed
horse chestnut seed and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- ibuprofen
ibuprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- ibuprofen IV
ibuprofen IV and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- indomethacin
indomethacin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- ketoprofen
ketoprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- ketorolac
ketorolac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- ketorolac intranasal
ketorolac intranasal and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- lornoxicam
lornoxicam and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- meclofenamate
meclofenamate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- mefenamic acid
mefenamic acid and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- meloxicam
meloxicam and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- mistletoe
Siberian ginseng increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nabumetone
nabumetone and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- naproxen
naproxen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- nettle
Siberian ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- oxaprozin
oxaprozin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- panax ginseng
panax ginseng and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- parecoxib
parecoxib and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- pau d'arco
pau d'arco and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- phenindione
phenindione and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- phytoestrogens
phytoestrogens and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- piroxicam
piroxicam and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- protamine
protamine and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- reishi
reishi and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- reteplase
reteplase and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- salicylates (non-asa)
salicylates (non-asa) and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- salsalate
salsalate and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- sulfasalazine
sulfasalazine and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- sulindac
sulindac and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- tenecteplase
tenecteplase and Siberian ginseng both increase anticoagulation. Modify Therapy/Monitor Closely.
- tolfenamic acid
tolfenamic acid and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- tolmetin
tolmetin and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- vitamin K1 (phytonadione)
Siberian ginseng increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Minor (36)
- amobarbital
Siberian ginseng increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- anamu
anamu and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.
- azelastine
Siberian ginseng increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- brompheniramine
Siberian ginseng increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- butabarbital
Siberian ginseng increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- butalbital
Siberian ginseng increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- carbinoxamine
Siberian ginseng increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- chloral hydrate
Siberian ginseng increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- chlorpheniramine
Siberian ginseng increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- cinnarizine
Siberian ginseng increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- clemastine
Siberian ginseng increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- cyclizine
Siberian ginseng increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- cyproheptadine
Siberian ginseng increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- danshen
danshen and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.
- devil's claw
devil's claw and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.
- dexchlorpheniramine
Siberian ginseng increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- dexmedetomidine
Siberian ginseng increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- digoxin
Siberian ginseng increases levels of digoxin by unknown mechanism. Minor/Significance Unknown.
- dimenhydrinate
Siberian ginseng increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- diphenhydramine
Siberian ginseng increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- doxylamine
Siberian ginseng increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- hydroxyzine
Siberian ginseng increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- insulin aspart
Siberian ginseng increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin detemir
Siberian ginseng increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin glargine
Siberian ginseng increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin glulisine
Siberian ginseng increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin lispro
Siberian ginseng increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin NPH
Siberian ginseng increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.
- insulin regular human
Siberian ginseng increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.
- pentobarbital
Siberian ginseng increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- phenobarbital
Siberian ginseng increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- primidone
Siberian ginseng increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- promethazine
Siberian ginseng increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- secobarbital
Siberian ginseng increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- triclofos
Siberian ginseng increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
- triprolidine
Siberian ginseng increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.
Adverse Effects
Frequency Not Defined
Anxiety
Drowsiness
Headache
Hypertension
Hypoglycemia
Insomnia
Irritability
Mastalgia
Muscle spasms
Nerve inflammation
Palpitations
Pericardial pain
Tachycardia
Warnings
Contraindications
Breast cancer, endometrial cancer, endometriosis, febrile conditions, hormone sensitive conditions, hypertension, ovarian cancer, uterine fibroids
Cautions
CAD, cardiovascular disorders, mania, MI, psychiatric disorders, rheumatic heart disease, schizophrenia
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Eleuthorosides A through M modulate pituitary-adrenocortical axis
Antioxidant and immunostimulant activity