acetaminophen rectal (OTC)

Brand and Other Names:Acephen, FeverAll, more...FeverAll Infants, FeverAll Junior Strength, Adults' FeverAll
  • Print

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

suppository

  • 80mg
  • 120mg
  • 325mg
  • 650mg

Antipyretic/Analgesic

325-650 mg PR q4-6hr PRN

Not to exceed 4 g/day

Administration

Patient should lie on left side with knees bent

Remove protective wrap before inserting

Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

Dosage Forms & Strengths

suppository

  • 80mg
  • 120mg
  • 325mg
  • 650mg

Antipyretic/Analgesic

3 months to 1 year: 80 mg PR q6hr PRN

1-3 years: 80 mg PR q4hr PRN

3-6 years: 120 mg PR q4-6hrPRN

6-12 years: 325 mg PR q4-6hr PRN

>12 years: As adults; 325-650 mg PR q4-6hr PRN

Maximum daily dose

  • <12 years: Not to exceed 5 doses/24 hr
  • ≥12 years: Not to exceed 4 g/day

Administration

Patient should lie on left side with knees bent

Remove protective wrap before inserting

Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

Next:

Interactions

Interaction Checker

and acetaminophen rectal

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (1)

              • lonafarnib

                acetaminophen rectal will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown.

              Monitor Closely (18)

              • avapritinib

                acetaminophen rectal will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • axitinib

                acetaminophen rectal increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • eltrombopag

                eltrombopag increases levels of acetaminophen rectal by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

              • finerenone

                acetaminophen rectal will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor serum potassium during initiation and dosage adjustment of either finererone or moderate CYP3A4 inhibitors. Adjust finererone dosage as needed.

              • flibanserin

                acetaminophen rectal will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.

              • imatinib

                imatinib decreases levels of acetaminophen rectal by decreasing hepatic clearance. Modify Therapy/Monitor Closely. In vitro, imatinib was found to inhibit acetaminophen O-glucuronidation (Ki value of 58.5 micro-M) at therapeutic levels; avoid chronic acetaminophen therapy with imatinib; if occasional acetaminophen administered, do not exceed 1300 mg/day.

              • isavuconazonium sulfate

                acetaminophen rectal will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • isoniazid

                isoniazid will increase the level or effect of acetaminophen rectal by affecting hepatic enzyme CYP2E1 metabolism. Use Caution/Monitor.

              • ivacaftor

                acetaminophen rectal increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor when coadministered with weak CYP3A4 inhibitors .

              • lemborexant

                acetaminophen rectal will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.

              • levonorgestrel oral/ethinylestradiol/ferrous bisglycinate

                levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will decrease the level or effect of acetaminophen rectal by unknown mechanism. Use Caution/Monitor.

              • lomitapide

                acetaminophen rectal increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day.

              • midazolam intranasal

                acetaminophen rectal will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.

              • mipomersen

                mipomersen, acetaminophen rectal. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.

              • tazemetostat

                acetaminophen rectal will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • tetracaine

                tetracaine, acetaminophen rectal. Other (see comment). Use Caution/Monitor. Comment: Monitor for signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered.

              • tinidazole

                acetaminophen rectal will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • warfarin

                acetaminophen rectal increases effects of warfarin by anticoagulation. Use Caution/Monitor. Likely to occur at doses exceedin 1.3-2 g/day for multiple consecutive days.

              Minor (52)

              • acetazolamide

                acetazolamide decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • antithrombin alfa

                acetaminophen rectal increases effects of antithrombin alfa by unknown mechanism. Minor/Significance Unknown.

              • antithrombin III

                acetaminophen rectal increases effects of antithrombin III by unknown mechanism. Minor/Significance Unknown.

              • argatroban

                acetaminophen rectal increases effects of argatroban by unknown mechanism. Minor/Significance Unknown.

              • bemiparin

                acetaminophen rectal increases effects of bemiparin by unknown mechanism. Minor/Significance Unknown.

              • bivalirudin

                acetaminophen rectal increases effects of bivalirudin by unknown mechanism. Minor/Significance Unknown.

              • busulfan

                acetaminophen rectal increases levels of busulfan by decreasing metabolism. Minor/Significance Unknown.

              • carbamazepine

                carbamazepine decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • cholestyramine

                cholestyramine decreases levels of acetaminophen rectal by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • clonazepam

                clonazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • colestipol

                colestipol decreases levels of acetaminophen rectal by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • dalteparin

                acetaminophen rectal increases effects of dalteparin by unknown mechanism. Minor/Significance Unknown.

              • diazepam

                diazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • disulfiram

                disulfiram will increase the level or effect of acetaminophen rectal by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

              • enoxaparin

                acetaminophen rectal increases effects of enoxaparin by unknown mechanism. Minor/Significance Unknown.

              • ethanol

                ethanol will decrease the level or effect of acetaminophen rectal by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

                ethanol increases toxicity of acetaminophen rectal by decreasing metabolism. Minor/Significance Unknown.

              • ethosuximide

                ethosuximide decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • exenatide injectable solution

                exenatide injectable solution decreases levels of acetaminophen rectal by unspecified interaction mechanism. Minor/Significance Unknown.

              • exenatide injectable suspension

                exenatide injectable suspension decreases levels of acetaminophen rectal by unspecified interaction mechanism. Minor/Significance Unknown.

              • felbamate

                felbamate decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • fondaparinux

                acetaminophen rectal increases effects of fondaparinux by unknown mechanism. Minor/Significance Unknown.

              • fosphenytoin

                fosphenytoin decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • gabapentin

                gabapentin decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • gabapentin enacarbil

                gabapentin enacarbil decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • green tea

                green tea increases effects of acetaminophen rectal by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical, due to caffeine content).

              • heparin

                acetaminophen rectal increases effects of heparin by unknown mechanism. Minor/Significance Unknown.

              • isoniazid

                isoniazid increases toxicity of acetaminophen rectal by unknown mechanism. Minor/Significance Unknown.

              • lacosamide

                lacosamide decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • lamotrigine

                lamotrigine decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • levetiracetam

                levetiracetam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • lorazepam

                lorazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • methsuximide

                methsuximide decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • metoclopramide

                metoclopramide increases levels of acetaminophen rectal by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • metronidazole

                metronidazole will increase the level or effect of acetaminophen rectal by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

              • oxcarbazepine

                oxcarbazepine decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • oxybutynin

                oxybutynin decreases levels of acetaminophen rectal by unspecified interaction mechanism. Minor/Significance Unknown.

              • oxybutynin topical

                oxybutynin topical decreases levels of acetaminophen rectal by unspecified interaction mechanism. Minor/Significance Unknown.

              • oxybutynin transdermal

                oxybutynin transdermal decreases levels of acetaminophen rectal by unspecified interaction mechanism. Minor/Significance Unknown.

              • phenindione

                acetaminophen rectal increases effects of phenindione by unknown mechanism. Minor/Significance Unknown.

              • phenobarbital

                phenobarbital decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • phenytoin

                phenytoin decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • primidone

                primidone decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • protamine

                acetaminophen rectal increases effects of protamine by unknown mechanism. Minor/Significance Unknown.

              • rifabutin

                rifabutin decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • rifampin

                rifampin decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • rufinamide

                rufinamide decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • ruxolitinib

                acetaminophen rectal will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

              • ruxolitinib topical

                acetaminophen rectal will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

              • tiagabine

                tiagabine decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • topiramate

                topiramate decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • valproic acid

                valproic acid decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • zonisamide

                zonisamide decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              Previous
              Next:

              Adverse Effects

              Frequency Not Defined

              Pruritic maculopapular rash

              Urticaria

              Rectal discomfort

              Angioedema

              Increase in bilirubin, alkaline phosphatase

              Nephrotoxicity (chronic overdose)

              Analgesic nephropathy

              Decrease in chloride, glucose, uric acid

              Laryngeal edema

              Agranulocytosis

              Decrease in bicarbonate, sodium, calcium

              Leukopenia

              Neutropenia

              Pancytopenia

              Thrombocytopenia

              Thrombocytopenic purpura

              Anaphylactoid reaction

              Previous
              Next:

              Warnings

              Contraindications

              Hypersensitivity

              Cautions

              For rectal use only

              Avoid overdose by checking product labels carefully; acetaminophen is found in many dosage forms and many combination products

              If not sure whether a drug contains acetaminophen, ask a physician or a pharmacist

              If experiencing liver disease, ask a physician or a pharmacist before using

              Ask a physician or pharmacist if taking warfarin or blood-thinning products

              Discontinue use and ask a physician if fever lasts >3 days (72 h) or recurs, pain lasts >5 days continuously or recurs

              Use caution in patients with known G6PD deficiency

              Risk of hepatotoxicity is higher in alcoholics, chronic high dose

              Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

              Previous
              Next:

              Pregnancy & Lactation

              Pregnancy category: B; Crosses placenta, safe to use in all stages of pregnancy short term

              Lactation: Excreted in breast milk; compatible w/ breastfeeding

              Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

              Previous
              Next:

              Pharmacology

              Mechanism of Action

              Inhibits prostaglandin synthesis in the CNS and works peripherally to block pain impulse generation; acts on hypothalamus to produce antipyresis

              Pharmacokinetics

              Onset: 1 hr

              Duration: 4-6 hr (analgesia)

              Half-life: 2.4 hr (adolescents); 2-3 hr (adults); 2-5 hr (children); 4-10 hr (neonates)

              Plasma Time: 107-288 min

              Peak Plasma Concentration: dose-dependent; (10 mg/kg) 5.5 mcg/mL, (20 mg/kg) 8.8 mcg/mL, (30 mg/kg) 14.2 mcg/mL

              Protein Bound: 10-25% (therapeutic concentrations); 43% (toxic concentrations)

              Distribution: 1 L/kg

              Metabolism: Liver (microsomal enzyme systems); conjugation (glucuronic/sulfuric acid)

              Metabolites: N-acetyl-p-benzoquinoneimine, N-acetylimidoquinone, NAPQI; further metabolized via conjugation with glutathione

              Excretion: <5% is excreted in the urine as unconjugated (free) acetaminophen and 60-80% as glucuronide metabolites

              Hemodialysis: Yes

              Previous
              Next:

              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              Tylenol Arthritis Pain oral
              -
              650 mg tablet
              Infant's Tylenol oral
              -
              160 mg/5 mL suspension
              Tylenol Extra Strength oral
              -
              500 mg tablet
              Arthritis Pain Reliever oral
              -
              650 mg tablet
              Mapap Arthritis Pain oral
              -
              650 mg tablet
              Mapap Arthritis Pain oral
              -
              650 mg tablet
              Acetaminophen Extra Strength oral
              -
              500 mg tablet
              Acetaminophen Extra Strength oral
              -
              500 mg tablet
              Pain Reliever Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              Pain Reliever Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              Pain Reliever Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              Pain Reliever Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              650 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              160 mg/5 mL liquid
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              80 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              650 mg tablet
              acetaminophen oral
              -
              650 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              160 mg/5 mL (5 mL) solution
              Tylenol oral
              -
              325 mg tablet
              Tylenol oral
              -
              325 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              325 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              325 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              325 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              500 mg tablet
              Mapap (acetaminophen) oral
              -
              325 mg tablet
              Mapap (acetaminophen) oral
              -
              500 mg capsule
              Non-Aspirin oral
              -
              325 mg tablet
              Non-Aspirin oral
              -
              325 mg tablet
              Non-Aspirin oral
              -
              325 mg tablet
              Non-Aspirin oral
              -
              325 mg tablet
              Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              325 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              325 mg tablet
              Pain Relief (acetaminophen) oral
              -
              160 mg/5 mL liquid
              Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Pain Relief (acetaminophen) oral
              -
              160 mg/5 mL liquid
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief Extra Strength (acetaminophen) oral
              -
              500 mg tablet
              Children's Tylenol oral
              -
              160 mg chewable tablet
              Children's Tylenol oral
              -
              160 mg chewable tablet
              Tylenol 8 Hour oral
              -
              650 mg tablet
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Acetaminophen oral
              -
              32 mg/mL solution
              Children's Acetaminophen oral
              -
              160 mg/5 mL (5 mL) suspension
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Non-Aspirin oral
              -
              160 mg/5 mL suspension
              Children's Non-Aspirin oral
              -
              160 mg/5 mL suspension
              Children's Non-Aspirin oral
              -
              160 mg/5 mL suspension
              Children's Pain Relief oral
              -
              160 mg/5 mL suspension
              Ofirmev intravenous
              -
              1,000 mg/100 mL (10 mg/mL) vial
              acetaminophen intravenous
              -
              1,000 mg/100 mL (10 mg/mL) vial
              acetaminophen intravenous
              -
              1,000 mg/100 mL (10 mg/mL) vial
              acetaminophen intravenous
              -
              1,000 mg/100 mL (10 mg/mL) vial
              8 Hour Pain Reliever oral
              -
              650 mg tablet
              8 Hour Pain Reliever oral
              -
              650 mg tablet
              8 Hour Pain Reliever oral
              -
              650 mg tablet
              Non-Aspirin Extra Strength oral
              -
              500 mg tablet
              Non-Aspirin Extra Strength oral
              -
              500 mg tablet
              Non-Aspirin Extra Strength oral
              -
              500 mg tablet
              Feverall rectal
              -
              80 mg suppos
              Feverall rectal
              -
              325 mg suppos
              Feverall rectal
              -
              650 mg suppos
              Feverall rectal
              -
              120 mg suppos
              Feverall rectal
              -
              80 mg suppos
              Feverall rectal
              -
              325 mg suppos
              Feverall rectal
              -
              120 mg suppos
              8HR Muscle Aches-Pain oral
              -
              650 mg tablet
              acetaminophen rectal
              -
              650 mg suppos
              acetaminophen rectal
              -
              120 mg suppos
              acetaminophen rectal
              -
              120 mg suppos
              acetaminophen rectal
              -
              650 mg suppos
              acetaminophen rectal
              -
              650 mg suppos
              Tactinal oral
              -
              325 mg tablet
              M-PAP oral
              -
              160 mg/5 mL liquid
              M-PAP oral
              -
              160 mg/5 mL liquid
              Arthritis Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Arthritis Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Infants' Pain Relief oral
              -
              160 mg/5 mL suspension
              Little Remedies Fever and Pain Reliever oral
              -
              160 mg/5 mL liquid
              Children's Mapap oral
              -
              80 mg chewable tablet
              Pharbetol oral
              -
              500 mg tablet
              Pharbetol oral
              -
              325 mg tablet

              Copyright © 2010 First DataBank, Inc.

              Previous
              Next:

              Patient Handout

              Select a drug:
              Patient Education
              acetaminophen intravenous

              ACETAMINOPHEN - INJECTION

              (a-SEET-a-MIN-oh-fen)

              COMMON BRAND NAME(S): Ofirmev

              WARNING: Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.See also How to Use.

              USES: This drug is used to treat mild to moderate pain and to reduce fever. It is also used in combination with opioid pain medications to help relieve moderate to severe pain.

              HOW TO USE: See also Warning section.Read the Patient Information Leaflet if available from your pharmacist before you start using acetaminophen and each time you get a refill. If you have any questions, ask your doctor or pharmacist.This medication is given by injection into a vein as directed by your doctor, usually every 4 to 6 hours as needed for pain relief or to reduce fever. Each dose is usually given over 15 minutes.The dosage is based on your medical condition, age, weight, and response to treatment. For children 12 years of age and younger, and for adults and teenagers weighing less than 110 pounds (50 kilograms), the dosage is based on weight and the maximum daily dosage is less than 4000 milligrams of acetaminophen. Consult your doctor or pharmacist for more details.If you are using this medication at home, learn all preparation and usage instructions from your health care professional for this drug and for the infusion pump. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.Tell your doctor if your condition lasts or gets worse.

              SIDE EFFECTS: See also Warning section.Pain at the injection site may occur. Other side effects are uncommon. If you have any unusual side effects, contact your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: See also Warning section.Before using acetaminophen, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this product, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, regular use/abuse of alcohol.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this form of acetaminophen passes into breast milk. However, acetaminophen taken by mouth passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: See also Warning section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: ketoconazole, levoketoconazole.This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, dark urine.

              NOTES: Lab and/or medical tests may be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.

              MISSED DOSE: Not applicable.

              STORAGE: If you are using this medication at home, consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

              Information last revised December 2022. Copyright(c) 2023 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

              Previous
              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.