Suggested Dosing
Dried root: 300-2000 mg PO TID
Extract: 0.3-2 mL PO daily; 1:1, 90% alcohol
Tincture: 2-4 mL PO daily; 1:10, 60% alcohol
Tablet: 20-80 mg PO BID; standardized to 1 mg triterpene glycosides/20 mg tablet
Suggested Uses
Cough/sore throat, dysmenorrhea, dyspepsia, labor induction, menopausal symptoms, nervous tension, premenstrual syndrome, rheumatism
Efficacy
Likely effective for menopausal vasomotor symptoms
Possibly effective for PMS/dysmenorrhea
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
Frequency Not Defined
Cramping
Dizziness
GI upset
Headache
Sweating
Weight gain
Rash
Overdose: Bradycardia
CNS disturbances
Nausea/vomiting
Visual disturbances
Warnings
Contraindications
Breast cancer, endometrial cancer, endometriosis, hormone sensitive conditions, ovarian cancer, pregnancy, lactation, uterine fibroids
Cautions
May be associated with liver damage
Pregnancy & Lactation
Pregnancy Category: unsafe
Lactation: unsafe
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
May act by blocking serotonin reuptake
