Grape Seed Extract (Herbs/Suppl)

Brand and Other Names:activin, leucoanthocyanin, more...Muscat, muskat, pine bark extract, pinus maritima, pinus nigra, proanthodyn, pycnogenol, vitis coignetiae, vitis vinifera
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Suggested Dosing

Chronic Venous Insufficiency

Extract procyanidin: 150-300 mg PO qD

Tablets/Capsules: 75-300 mg/d for 3 weeks, THEN 40-80 mg/d OR

360 mg or 720 mg once daily (Antistax, Boehringer Ingelheim) PO qD

Ocular Stress Reduction

Extract procyanidin: 200-300 mg PO qD

Other Information

Endometriosis (based on RCT): 30 mg PO BID

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Suggested Uses

Atherosclerosis, attention deficit disorder, cancer (prevention), chronic venous insufficiency, collagen breakdown (prevention), dental caries prevention, macular degeneration, peripheral vascular disease, poor night vision, retinopathy, varicose veins, endometriosis

Efficacy

Effective in relieving symptoms of circulatory disorders

One RCT indicates effective in reducing symptoms of endometriosis (Kohama, J. Reprod Med)

Not effective against signs of aging, collagen destruction

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Adverse Effects

Frequency Not Defined

None reported

Potential for hepatotoxicity

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Warnings

Contraindications

None reported

Cautions

None reported

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Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Proanthocyanidins: antioxidants

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.