Dosing & Uses
Dosage Forms & Strengths
ophthalmic solution
- 0.4% (Acular LS)
- 0.45% (Acuvail)
- 0.5% (Acular)
Allergic Conjunctivitis
Indicated for temporary relief of ocular itching caused by seasonal allergic conjunctivitis
Acular: Instill 1 gtt in affected eye(s) q6hr
Ocular Pain & Inflammation
Indicated for pain and inflammation following catarac surgery
Acuvail: Instill 1 gtt to affected eye(s) twice daily beginning 1 day before surgery and on day of surgery and continue through the first 2 weeks postoperatively
Acular: Instill 1 gtt in affected eye(s) four times daily starting 24 hr after surgery and continue up to 4 days after surgery
Ocular Pain & Burning/Stinging
Indicated to reduce ocular pain and burning/stinging following corneal refractive surgery
Acular LS: Instill 1 gtt in the operated eye PRN for up to 4 days postoperatively
Cystoid Macular Edema (Off-label)
Prevention of postoperatvie cystoid macular edema
1-2 gtt in affected eye(s) q6-8hr beginning 24 hr pre-op and continuing 3-4 wk postoperatively
Dosage Forms & Strengths
ophthalmic solution
- 0.4% (Acular LS)
- 0.45% (Acuvail)
- 0.5% (Acular)
Allergic Conjunctivitis
Indicated for temporary relief of ocular itching caused by seasonal allergic conjunctivitis
<2 years: Safety and efficacy not established
>2 years: Instill 1 gtt in affected eye(s) q6hr (Acular)
Ocular Pain & Inflammation
Indicated for pain and inflammation following catarac surgery
<2 years: Safety and efficacy not established
>2 years: Instill 1 gtt (Acular) in affected eye(s) q6hr starting 24 hr after surgery and continue through the first 2 weeks postoperatively
Ocular Pain & Burning/Stinging
Indicated to reduce ocular pain and burning/stinging following corneal refractive surgery
<2 years: Safety and efficacy not established
>2 years: Instill 1 gtt (Acular LS) in operated eye PRN for up to 4 days postoperatively
Adverse Effects
>10%
Transient ocular burning/stinging
1-10%
Conjunctival hyperemia
Corneal edema
Iritis
Corneal infiltrates
Iritis
Corneal edema
Ocular inflammation
Ocular irritation
Ocular pain
Increased ocular pressure
Superficial keratitis
Superficial ocular infection
<1%
Blurred vision
Corneal ulcer
Corneal erosion
Corneal thinning
Perforation of cornea
Dry eyes
Epithelial breakdown
Corneal epithelial degeneration
Postmarketing reports
Bronchospasm, exacerbation of asthma, and epithelial breakdown
Warnings
Contraindications
Hypersensitivity to ASA, NSAIDs, or ingredients in the formulation
Cautions
Ocular infection possible following surgery; patients should use two bottles should not use the same bottle for both eyes
Safety and efficacy of Acular LS not established in postcataract surgery patients
NSAIDs may delay healing; concomitant use of topical NSAIDs and topical steroids may increase potential for healing problems
Cross-sensitivity or hypersensitivity may occur between other NSAIDs, acetylsalicylic acid, and phenylacetic acid derivatives; bronchospasm or exacerbation of asthma associated with use in patients who have either a known hypersensitivity to aspirin/non-steroidal anti-inflammatory drugs or a past medical history of asthma; caution when treating individuals who have previously exhibited sensitivities to these drugs
Increased bleeding time due to interference with thrombocyte aggregation; reports that ocularly applied NSAIDs may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery; ophthalmic solution be used with caution in patients with known bleeding tendencies or receiving other medications, which may prolong bleeding time
Do not administer while wearing contact lenses
Do not allow the tip of the bottle to contact the eye or surrounding structures because this could cause the tip to become contaminated by common bacteria known to cause ocular infections; serious damage to the eye and subsequent loss of vision may result from using contaminated solutions
Corneal effects
- May cause keratitis, and in some susceptible patients, chronic use may cause epithelial breakdown, corneal thinning, corneal erosion, corneal ulceration, or corneal perforation; these events may be sight-threatening; patients with evidence of corneal epithelial breakdown should immediately discontinue use of topical NSAIDs and be closely monitored for corneal health
- Postmarketing experience with topical NSAIDs suggests that patients with complicated ocular surgeries, corneal denervation, corneal epithelial defects, diabetes mellitus, ocular surface diseases (eg, dry eye syndrome), rheumatoid arthritis, or repeat ocular surgeries within a short period of time may be at increased risk for corneal adverse events which may become sight-threatening; topical NSAIDs should be used with caution in these patients
- Postmarketing experience with topical NSAIDs suggests that use more than 1 day prior to surgery or use beyond 14 days post-surgery may increase patient risk for occurrence and severity of corneal adverse events
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Unknown; use with caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Nonsteroidal anti-inflammatory agent; reduces production of prostaglandin precursors by inhibiting COX-1 and COX-2; has anti-inflammatory properties
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 30 mg/mL vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 15 mg/mL solution | ![]() | |
ketorolac injection - | 30 mg/mL solution | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 30 mg/mL solution | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 30 mg/mL (1 mL) vial | ![]() | |
ketorolac injection - | 15 mg/mL vial | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.4 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
ketorolac ophthalmic (eye) - | 0.5 % drops | ![]() | |
Acular LS ophthalmic (eye) - | 0.4 % drops | ![]() | |
ketorolac nasal - | 15.75 mg/spray liquid | ![]() | |
Sprix nasal - | 15.75 mg/spray liquid | ![]() | |
Sprix nasal - | 15.75 mg/spray liquid | ![]() | |
ketorolac oral - | 10 mg tablet | ![]() | |
ketorolac oral - | 10 mg tablet | ![]() | |
ketorolac oral - | 10 mg tablet | ![]() | |
ketorolac oral - | 10 mg tablet | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL solution | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL solution | ![]() | |
ketorolac intramuscular - | 60 mg/2 mL vial | ![]() | |
Acular ophthalmic (eye) - | 0.5 % drops | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
ketorolac injection
KETOROLAC - INJECTION
(KEE-toe-ROLE-ak)
COMMON BRAND NAME(S): Toradol
WARNING: It is important that you use this medication properly to help reduce your risk of side effects. Your doctor may adjust your dose if you are older, have low body weight, or have kidney problems.Nonsteroidal anti-inflammatory drugs (including ketorolac) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while using this drug but is more likely if you use it for a long time. The risk may be greater in older adults or if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Talk to your doctor about the benefits and risks of using this drug.This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while using this drug. Older adults may be at higher risk for this effect. Do not use this medication if you have stomach/intestinal problems (such as bleeding, ulcers).Stop using ketorolac and get medical help right away if you notice any of the following rare but serious side effects: stomach/abdominal pain that doesn't go away, bloody or black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, trouble speaking.Do not use this drug right before or after heart bypass surgery (CABG) or before any surgery. It also should not be used during labor/delivery or in people with severe kidney problems or high risk for kidney problems. Do not use ketorolac if you are taking high doses of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). See also Drug Interactions section.
USES: Ketorolac is used for the short-term treatment of moderate to severe pain. It is usually used before or after medical procedures or after surgery. Reducing pain helps you recover more comfortably so that you can return to your normal daily activities. This medication is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.Ketorolac should not be used for mild or long-term painful conditions (such as arthritis).
HOW TO USE: Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using ketorolac. If you have any questions, ask your doctor or pharmacist.This medication is given by injection into a muscle or vein as directed by your doctor. It may be given as a one-time dose or given on a regular schedule. If given on a regular schedule, it is usually injected every 6 hours as needed, or as directed by your doctor. This drug must not be injected into the spine.Dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, use this medication at the lowest effective dose for the shortest possible time. Do not increase your dose, use it more often, or use it for longer than 5 days. If you still have pain after 5 days, talk with your doctor about other medications you may use.If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.If you have "breakthrough" pain while using this medication, ask your doctor about other medications that you can use with this drug. Tell your doctor if your condition worsens or if your pain is not relieved.
SIDE EFFECTS: See also Warning section.Pain at the injection site, dizziness, drowsiness, headache, or upset stomach may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.Tell your doctor right away if you have any serious side effects, including: headache that is severe or doesn't go away, fainting, fast/pounding heartbeat, hearing changes (such as ringing in the ears), mental/mood changes (such as confusion, depression), stomach pain, vision changes (such as blurred vision), easy bruising/bleeding, signs of kidney problems (such as change in the amount of urine), symptoms of meningitis (such as unexplained stiff neck, fever), symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: nausea/vomiting that doesn't stop, dark urine, stomach/abdominal pain, yellowing eyes/skin.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using ketorolac, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other nonsteroidal anti-inflammatory drugs-NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), bleeding or clotting problems, blood disorders (such as anemia), heart disease (such as previous heart attack), high blood pressure, liver disease, growths in the nose (nasal polyps), throat/stomach/intestinal problems (such as bleeding, heartburn, ulcers), stroke, swelling of the ankles/feet/hands.Kidney problems can sometimes occur with the use of NSAID medications, including ketorolac. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).This medicine may cause stomach/intestinal bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be at greater risk for stomach/intestinal bleeding, kidney problems, heart attack, and stroke while using this drug.Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks. Tell your doctor if you are pregnant or if you plan to become pregnant. This medication may harm an unborn baby and cause problems with normal labor/delivery. It is not recommended for use in pregnancy from 20 weeks until delivery. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. You should not use this medication after 30 weeks of pregnancy.This drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), corticosteroids (such as prednisone), methotrexate, probenecid, other medications that may affect the kidneys (including cidofovir), "water pills" (diuretics such as furosemide).This medication may increase the risk of bleeding when used with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include lithium, pemetrexed, among others.Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen or naproxen). These drugs are similar to ketorolac and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach pain, vomit that looks like coffee grounds, extreme drowsiness, slow/shallow breathing.
NOTES: Do not share this medication with others.Lab and/or medical tests (including blood pressure, kidney function) may be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case.
MISSED DOSE: It is important to get each dose of this medication as scheduled. If you are using this drug on a regular schedule (not "as needed") and you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.