Same (Herb/Suppl)

AIDS-related myelopathy, Alzheimer's disease, bursitis/tendinitis, depression, fibromyalgia, heart disease, intrahepatic cholestasis, liver disease, migraine headache, osteoarthritis

Efficacy

Several studies showed comparable effectiveness to TCAs

Standardization of product not as good in US as in Europe

Oral form has poor bioavailability; pos. studies used parenteral SAMe

Mult clinical trials showed comparable effectiveness to NSAIDS, with fewer side effects

Studies showed possibly effective for the treatment of AIDS-related myelopathy, fibromyalgia,& intrahepatic cholestasis

Frequency Not Defined

Anxiety

Diarrhea

Flatulence

Headache

Hypomania/mania

Nausea/vomiting

Contraindications

MAO inhibitor use within 14 day

Cautions

Bipolar disorder

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Methyl donor in many metabolic reactions