Glandular Products (Herb/Suppl)

Brand and Other Names:adrenal extract, aortic glycosaminoglycans (GAGs), more...liver extract, pancreatic extract, spleen extract, thymus extract, thyroid extract

Suggested Dosing

Adrenal extract

Varies depending on product; follow label recommendations, and titrate as indicated

Aortic glycosaminoglycans (GAGs)

Typical Dose

  • 100 mg PO qDay

Cerebrovascular disease

  • 100-144 mg/day PO
  • 30 mg IM BID

DVT

  • 72 mg/day PO

Hypertriglyceridemia

  • 96 mg/day PO

Liver extract

Varies depending on product; follow label recommendations, and titrate as indicated

Pancreas USP extract

500-1000 mg PO TID, with or without meals

Spleen extract

1.5 g spleen peptides (50 mg tuftsin & splenopentin)/day

Thymus extract

120 mg pure polypeptides or 750 mg crude polypeptide fraction/day

Thyroid extract

Varies depending on product; follow label recommendations, and titrate as indicated

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Suggested Uses

Adrenal extract

Oral

  • Low adrenal function; fatigue; stress; impaired resistance to illness; severe allergies, asthma, eczema, psoriasis, rheumatoid arthritis, and other inflammatory conditions.

Sublingual

  • fatigue or exhaustion, poor stress tolerance, allergies, auto-immune disorders, depression, inflammation, low blood pressure, hypoglycemia, drug & alcohol withdrawal, and discontinuing cortisone drugs

IV

  • Adrenal cortical insufficiency, hyperkalemia, ulcerative colitis, status thymicolymphaticus, and preventing spontaneous abortion

Aortic glycosaminoglycans (GAGs)

Vascular insufficiencies

Liver

Adjunctive therapy in hepatic disorders, source of heme iron, allergies, chronic fatigue syndrome, enhancing muscle development in bodybuilders, improving strength & stamina

Pancreas

Digestive aid (with food); anti-inflammatory, herpes zoster, immune complex diseases

Spleen

Post-splenectomy; SLE, AIDS, colitis, RA, low WBC count, thrombocytopenia, ulcerative colitis, & enhancing immune function in cancer patients

Thymus

Immune system modulation (URI, hepatitis B, AIDS, allergies), cancer, rheumatoid arthritis, CFS, lupus, WBC production in cancer patients treated with radiation or chemo, and aging

Thyroid

Hypothyroidism

Efficacy

Depends on extraction method; predigested soluble concentrates tend to be most effective

Many physiological studies demonstrate GI absorption of intact macromolecules (polypeptides, etc)

Human trials show efficacy for listed uses

Thyroid extract more difficult to calibrate than synthetic hormones

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Interactions

Interaction Checker

and Glandular Products

No Results

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (3)

                  • levothyroxine

                    glandular products increases effects of levothyroxine by pharmacodynamic synergism. Minor/Significance Unknown. Additive effects with thyroid glandular extract.

                  • liothyronine

                    glandular products increases effects of liothyronine by pharmacodynamic synergism. Minor/Significance Unknown. Additive effects with thyroid glandular extract.

                  • thyroid desiccated

                    glandular products increases effects of thyroid desiccated by pharmacodynamic synergism. Minor/Significance Unknown. Additive effects with thyroid glandular extract.

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                  Adverse Effects

                  Allergic reaction

                  Infection or other symptoms d/t contaminants (rare)

                  Liver extract: iron overload, hemochromatosis

                  Thyroid extract: hyperthyroid symptoms (large dose)

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                  Warnings

                  Contraindications

                  Hypersensitivity to bovine/porcine products

                  Cautions

                  Extracts or preparation of whole glandular tissue, usually from bovine or porcine sources

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                  Pregnancy & Lactation

                  Pregnancy Category: N/A

                  Lactation: N/A

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: N/A

                  Excretion: N/A

                  Mechanism of Action

                  Biochemical mixture in extract provides specific nutritional support for corresponding gland

                  Hormonal content may exert direct effects on target cells

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.