Suggested Dosing
Follow manufacturer's protocol
Commercial products suggest doses ranging from 500 mg-4.5 grams given PO in 2-6 divided doses daily
Suggested Uses
Cancer prevention & treatment
Treatment of arthritis & psoriasis
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (31)
- acarbose
shark cartilage increases effects of acarbose by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- bendroflumethiazide
bendroflumethiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- chlorothiazide
chlorothiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- chlorpropamide
shark cartilage increases effects of chlorpropamide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- chlorthalidone
chlorthalidone, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- cyclopenthiazide
cyclopenthiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- glimepiride
shark cartilage increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- glipizide
shark cartilage increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- glyburide
shark cartilage increases effects of glyburide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- hydrochlorothiazide
hydrochlorothiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- indapamide
indapamide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- insulin aspart
shark cartilage increases effects of insulin aspart by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- insulin detemir
shark cartilage increases effects of insulin detemir by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- insulin glargine
shark cartilage increases effects of insulin glargine by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- insulin glulisine
shark cartilage increases effects of insulin glulisine by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- insulin lispro
shark cartilage increases effects of insulin lispro by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- insulin NPH
shark cartilage increases effects of insulin NPH by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- insulin regular human
shark cartilage increases effects of insulin regular human by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- metformin
shark cartilage increases effects of metformin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- methyclothiazide
methyclothiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- metolazone
metolazone, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).
- miglitol
shark cartilage increases effects of miglitol by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- nateglinide
shark cartilage increases effects of nateglinide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- pioglitazone
shark cartilage increases effects of pioglitazone by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- repaglinide
shark cartilage increases effects of repaglinide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- rosiglitazone
shark cartilage increases effects of rosiglitazone by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- saxagliptin
shark cartilage increases effects of saxagliptin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- sitagliptin
shark cartilage increases effects of sitagliptin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- tolazamide
shark cartilage increases effects of tolazamide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- tolbutamide
shark cartilage increases effects of tolbutamide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
- vildagliptin
shark cartilage increases effects of vildagliptin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
Minor (12)
- bitter melon
shark cartilage increases effects of bitter melon by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced blood sugar lowering effects (theoretical interaction).
- calcium acetate
calcium acetate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).
- calcium carbonate
calcium carbonate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).
- calcium chloride
calcium chloride, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).
- calcium citrate
calcium citrate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).
- calcium gluconate
calcium gluconate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).
- fenugreek
shark cartilage increases effects of fenugreek by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced blood sugar lowering effects (theoretical interaction).
- gymnema
shark cartilage increases effects of gymnema by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced blood sugar lowering effects (theoretical interaction).
- interferon alfa 2b
interferon alfa 2b, shark cartilage. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced anti angiogenesis (theoretical interaction).
- juice (fruit)
juice (fruit) decreases levels of shark cartilage by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- leflunomide
leflunomide, shark cartilage. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced anti angiogenesis (theoretical interaction).
- thalidomide
thalidomide, shark cartilage. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced anti angiogenesis (theoretical interaction).
Adverse Effects
Frequency Not Defined
Dark urine
Excessive fatigue
Extreme itchiness
Nausea
Vomiting or diarrhea
Pain or swelling in the upper right part of the abdomen
Yellowing of skin or white parts of eyes
Constipation
Dizziness
Dysgeusia
Low blood pressure
Nausea
Upset stomach
Vomiting
Weakness
Warnings
Contraindications
Pregnancy, lactation
Cautions
May contain heavy metal contaminants such as mercury & cadmium
Do not take in high doses or for long periods of time
Pregnancy & Lactation
Pregnancy Category: do not use
Lactation: do not use
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Inhibits angiogenesis & interferes with matrix metalloproteases (MMPs) enzymes
