Shark Cartilage (Herb/Suppl)

Brand and Other Names:AE941, Neovastat, more...U995
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Suggested Dosing

Follow manufacturer's protocol

Commercial products suggest doses ranging from 500 mg-4.5 grams given PO in 2-6 divided doses daily

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Suggested Uses

Cancer prevention & treatment

Treatment of arthritis & psoriasis

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Interactions

Interaction Checker

and Shark Cartilage

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (31)

                • acarbose

                  shark cartilage increases effects of acarbose by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • bendroflumethiazide

                  bendroflumethiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • chlorothiazide

                  chlorothiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • chlorpropamide

                  shark cartilage increases effects of chlorpropamide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • chlorthalidone

                  chlorthalidone, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • cyclopenthiazide

                  cyclopenthiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • glimepiride

                  shark cartilage increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • glipizide

                  shark cartilage increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • glyburide

                  shark cartilage increases effects of glyburide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • hydrochlorothiazide

                  hydrochlorothiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • indapamide

                  indapamide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • insulin aspart

                  shark cartilage increases effects of insulin aspart by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • insulin detemir

                  shark cartilage increases effects of insulin detemir by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • insulin glargine

                  shark cartilage increases effects of insulin glargine by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • insulin glulisine

                  shark cartilage increases effects of insulin glulisine by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • insulin lispro

                  shark cartilage increases effects of insulin lispro by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • insulin NPH

                  shark cartilage increases effects of insulin NPH by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • insulin regular human

                  shark cartilage increases effects of insulin regular human by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • metformin

                  shark cartilage increases effects of metformin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • methyclothiazide

                  methyclothiazide, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • metolazone

                  metolazone, shark cartilage. Other (see comment). Use Caution/Monitor. Comment: May lead to hypercalcemia (theoretical).

                • miglitol

                  shark cartilage increases effects of miglitol by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • nateglinide

                  shark cartilage increases effects of nateglinide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • pioglitazone

                  shark cartilage increases effects of pioglitazone by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • repaglinide

                  shark cartilage increases effects of repaglinide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • rosiglitazone

                  shark cartilage increases effects of rosiglitazone by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • saxagliptin

                  shark cartilage increases effects of saxagliptin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • sitagliptin

                  shark cartilage increases effects of sitagliptin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • tolazamide

                  shark cartilage increases effects of tolazamide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • tolbutamide

                  shark cartilage increases effects of tolbutamide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                • vildagliptin

                  shark cartilage increases effects of vildagliptin by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.

                Minor (12)

                • bitter melon

                  shark cartilage increases effects of bitter melon by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced blood sugar lowering effects (theoretical interaction).

                • calcium acetate

                  calcium acetate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).

                • calcium carbonate

                  calcium carbonate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).

                • calcium chloride

                  calcium chloride, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).

                • calcium citrate

                  calcium citrate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).

                • calcium gluconate

                  calcium gluconate, shark cartilage. pharmacodynamic synergism. Minor/Significance Unknown. May lead to hypercalcemia (theoretical).

                • fenugreek

                  shark cartilage increases effects of fenugreek by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced blood sugar lowering effects (theoretical interaction).

                • gymnema

                  shark cartilage increases effects of gymnema by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced blood sugar lowering effects (theoretical interaction).

                • interferon alfa 2b

                  interferon alfa 2b, shark cartilage. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced anti angiogenesis (theoretical interaction).

                • juice (fruit)

                  juice (fruit) decreases levels of shark cartilage by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • leflunomide

                  leflunomide, shark cartilage. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced anti angiogenesis (theoretical interaction).

                • thalidomide

                  thalidomide, shark cartilage. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Enhanced anti angiogenesis (theoretical interaction).

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                Adverse Effects

                Frequency Not Defined

                Dark urine

                Excessive fatigue

                Extreme itchiness

                Nausea

                Vomiting or diarrhea

                Pain or swelling in the upper right part of the abdomen

                Yellowing of skin or white parts of eyes

                Constipation

                Dizziness

                Dysgeusia

                Low blood pressure

                Nausea

                Upset stomach

                Vomiting

                Weakness

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                Warnings

                Contraindications

                Pregnancy, lactation

                Cautions

                May contain heavy metal contaminants such as mercury & cadmium

                Do not take in high doses or for long periods of time

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                Pregnancy & Lactation

                Pregnancy Category: do not use

                Lactation: do not use

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Inhibits angiogenesis & interferes with matrix metalloproteases (MMPs) enzymes

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.