Suggested Dosing
Seed Extract
250-750 mg/d PO in div doses
Tincture
1-4 ml PO TID
Other Information
Extract standardized to 20-22% saponins
Suggested Uses
Diarrhea, fever, hemorrhoids, phlebitis, prostate enlargement, varicose veins, venous insufficiency
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
Frequency Not Defined
Anaphylaxis (IV)
GI irritation
Itching
Kidney toxicity (IV)
Liver toxicity (IV)
Toxic nephropathy
Depression
Diarrhea
Incoordination
Muscle twitching
Paralysis
Pupil dilation
Stupor
Vomiting
Weakness
Warnings
Contraindications
Hepatitic impairment, infectious GI conditions, inflammatory GI conditions, renal impairment
Cautions
Bleeding disorders, concurrent hypoglycemic agents, diabetes mellitus
WARNING: use only standardized seed extract; raw seed, leaf, bark, or flower possibly fatal
Pregnancy & Lactation
Pregnancy Category: raw seed unsafe; avoid use
Lactation: avoid use
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Saponins: aescin: vasoconstrictor; aesculin (a hydroxycoumarin)- antithrombin activity
