Indication-specific dosing for aescin, Aesculaforce, aesculus hippocastanum horse chestnut seed in combination, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Horse Chestnut Seed (Herb/Suppl)

Brand and Other Names:aescin, Aesculaforce, more...aesculus hippocastanum, chestnut, de marronier d'Inde, eschilo, escine, graine de marronier d'Inde, HCSE, hippocastani semen, marron europeen, marronier, rosskastanie, Spanish chestnut, venastat, venostat, venostatin, Venostasin

Sections

Sections Horse Chestnut Seed
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

Seed Extract

250-750 mg/d PO in div doses

Tincture

1-4 ml PO TID

Other Information

Extract standardized to 20-22% saponins

Suggested Uses

Diarrhea, fever, hemorrhoids, phlebitis, prostate enlargement, varicose veins, venous insufficiency

Interaction Checker

Enter a drug name and Horse Chestnut Seed

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No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

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Frequency Not Defined

Anaphylaxis (IV)

GI irritation

Itching

Kidney toxicity (IV)

Liver toxicity (IV)

Toxic nephropathy

Depression

Diarrhea

Incoordination

Muscle twitching

Paralysis

Pupil dilation

Stupor

Vomiting

Weakness

Contraindications

Hepatitic impairment, infectious GI conditions, inflammatory GI conditions, renal impairment

Cautions

Bleeding disorders, concurrent hypoglycemic agents, diabetes mellitus

WARNING: use only standardized seed extract; raw seed, leaf, bark, or flower possibly fatal

Pregnancy & Lactation

Pregnancy Category: raw seed unsafe; avoid use

Lactation: avoid use

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Saponins: aescin: vasoconstrictor; aesculin (a hydroxycoumarin)- antithrombin activity

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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