Suggested Dosing
Topical
Apply 0.025%-0.075% TID-QID; minimum 4 weeks
May take up to 14 days for full analgesic effect
Avoid using near eyes or on sensitive skin
Wash hands after applying
Oral
Fruit: 30-120 PO TID
Tincture: 0.6-2 ml/dose PO
Oleoresin: 0.6-2 mg/dose PO
Intranasal
Migraine (Ausanil): Spray 1-2 times into nostril
Prurigo Nodularis
Apply 0.025%-0.3% topically 4-6 x/day
Suggested Uses
Post-herpetic pain (shingles)
Circulatory problems (peripheral), clotting disorders, diarrhea, digestion problems, fibromyalgia (topical), heart disease (prevention), neuralgias (topical), neuropathies (topical), pain syndromes (topical), prurigo nodularis
Migraine (intranasal)
Efficacy
Effective for pain relief
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (11)
- benazepril
capsicum, benazepril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- captopril
capsicum, captopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- enalapril
capsicum, enalapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- fosinopril
capsicum, fosinopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- imidapril
capsicum, imidapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- lisinopril
capsicum, lisinopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- moexipril
capsicum, moexipril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- perindopril
capsicum, perindopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- quinapril
capsicum, quinapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- ramipril
capsicum, ramipril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
- trandolapril
capsicum, trandolapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.
Adverse Effects
Frequency Not Defined
Bleeding
Local burning sensation
Contact dermatitis
Cough
Flushing
Gastroenteritis
GI irritation
Hepatic damage
Lacrimation
Mucous membrane irritation
Ocular irritation
Renal damage
Rhinorrhea
Sweating
Urticaria (topical use)
Warnings
Contraindications
Damaged skin (topical use), cuts, infected skin, hypersensitivity to product or excipients, infectious GI conditions (oral use), inflammatory GI conditions (oral use), open wounds (topical use), mouth, eyes, genital, or any other mucous membranes
Cautions
Concurrent sedative meds
Avoid touching eyes, nose, mouth, etc. after topical application until it is washed off
May experience a burning sensation following the application; the intensity of this reaction varies among individuals and may be severe; with regular use, this sensation generally disappears after several days
Do not tightly wrap or bandage the treated area
Do not apply heat to the treated area immediately before or after use
Discontinue use and see healthcare professional if experience rash, itching, or excessive skin irritation, condition worsens, symptoms persist for >7 days
Pregnancy & Lactation
Pregnancy
See healthcare professional
Lactation
See healthcare professional
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Active constituent, capsaicin, binds to neuronal transient potential vanilloid receptor 1 (TPRV1), depletes substance P; decreases pain perception
