Capsicum (Herb/Suppl)

Brand and Other Names:African chilies, Ausanil, more...capsaicin, cayenne, chili pepper, green chili pepper, Louisiana long pepper, Mexican chilies, paprika, pimento, red pepper, tabasco pepper
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Suggested Dosing

Topical

Apply 0.025%-0.075% TID-QID; minimum 4 weeks

May take up to 14 days for full analgesic effect

Avoid using near eyes or on sensitive skin

Wash hands after applying

Oral

Fruit: 30-120 PO TID

Tincture: 0.6-2 ml/dose PO

Oleoresin: 0.6-2 mg/dose PO

Intranasal

Migraine (Ausanil): Spray 1-2 times into nostril

Prurigo Nodularis

Apply 0.025%-0.3% topically 4-6 x/day

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Suggested Uses

Post-herpetic pain (shingles)

Circulatory problems (peripheral), clotting disorders, diarrhea, digestion problems, fibromyalgia (topical), heart disease (prevention), neuralgias (topical), neuropathies (topical), pain syndromes (topical), prurigo nodularis

Migraine (intranasal)

Efficacy

Effective for pain relief

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Interactions

Interaction Checker

and Capsicum

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (11)

                  • benazepril

                    capsicum, benazepril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • captopril

                    capsicum, captopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • enalapril

                    capsicum, enalapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • fosinopril

                    capsicum, fosinopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • imidapril

                    capsicum, imidapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • lisinopril

                    capsicum, lisinopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • moexipril

                    capsicum, moexipril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • perindopril

                    capsicum, perindopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • quinapril

                    capsicum, quinapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • ramipril

                    capsicum, ramipril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • trandolapril

                    capsicum, trandolapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

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                  Adverse Effects

                  Frequency Not Defined

                  Bleeding

                  Local burning sensation

                  Contact dermatitis

                  Cough

                  Flushing

                  Gastroenteritis

                  GI irritation

                  Hepatic damage

                  Lacrimation

                  Mucous membrane irritation

                  Ocular irritation

                  Renal damage

                  Rhinorrhea

                  Sweating

                  Urticaria (topical use)

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                  Warnings

                  Contraindications

                  Damaged skin (topical use), hypersensitivity to peppers, infectious GI conditions (oral use), inflammatory GI conditions (oral use), open wounds (topical use)

                  Cautions

                  Concurrent sedative meds

                  Avoid touching eyes, nose, mouth, etc. after topical application until it is washed off

                  Do not apply external heat after topical capsaicin application

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                  Pregnancy & Lactation

                  Pregnancy Category: N/A

                  Lactation: N/A

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Active constituent, capsaicin, binds to neuronal transient potential vanilloid receptor 1 (TPRV1), depletes substance P; decreases pain perception

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.