Capsicum (Herb/Suppl)

Brand and Other Names:African chilies, Ausanil, more...capsaicin, cayenne, chili pepper, green chili pepper, Louisiana long pepper, Mexican chilies, paprika, pimento, red pepper, tabasco pepper
  • Print

Suggested Dosing

Topical

Apply 0.025%-0.075% TID-QID; minimum 4 weeks

May take up to 14 days for full analgesic effect

Avoid using near eyes or on sensitive skin

Wash hands after applying

Oral

Fruit: 30-120 PO TID

Tincture: 0.6-2 ml/dose PO

Oleoresin: 0.6-2 mg/dose PO

Intranasal

Migraine (Ausanil): Spray 1-2 times into nostril

Prurigo Nodularis

Apply 0.025%-0.3% topically 4-6 x/day

Next:

Suggested Uses

Post-herpetic pain (shingles)

Circulatory problems (peripheral), clotting disorders, diarrhea, digestion problems, fibromyalgia (topical), heart disease (prevention), neuralgias (topical), neuropathies (topical), pain syndromes (topical), prurigo nodularis

Migraine (intranasal)

Efficacy

Effective for pain relief

Previous
Next:

Interactions

Interaction Checker

and Capsicum

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (11)

                  • benazepril

                    capsicum, benazepril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • captopril

                    capsicum, captopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • enalapril

                    capsicum, enalapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • fosinopril

                    capsicum, fosinopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • imidapril

                    capsicum, imidapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • lisinopril

                    capsicum, lisinopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • moexipril

                    capsicum, moexipril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • perindopril

                    capsicum, perindopril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • quinapril

                    capsicum, quinapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • ramipril

                    capsicum, ramipril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  • trandolapril

                    capsicum, trandolapril. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Increase ACE inhibitor induced cough.

                  Previous
                  Next:

                  Adverse Effects

                  Frequency Not Defined

                  Bleeding

                  Local burning sensation

                  Contact dermatitis

                  Cough

                  Flushing

                  Gastroenteritis

                  GI irritation

                  Hepatic damage

                  Lacrimation

                  Mucous membrane irritation

                  Ocular irritation

                  Renal damage

                  Rhinorrhea

                  Sweating

                  Urticaria (topical use)

                  Previous
                  Next:

                  Warnings

                  Contraindications

                  Damaged skin (topical use), cuts, infected skin, hypersensitivity to product or excipients, infectious GI conditions (oral use), inflammatory GI conditions (oral use), open wounds (topical use), mouth, eyes, genital, or any other mucous membranes

                  Cautions

                  Concurrent sedative meds

                  Avoid touching eyes, nose, mouth, etc. after topical application until it is washed off

                  May experience a burning sensation following the application; the intensity of this reaction varies among individuals and may be severe; with regular use, this sensation generally disappears after several days

                  Do not tightly wrap or bandage the treated area

                  Do not apply heat to the treated area immediately before or after use

                  Discontinue use and see healthcare professional if experience rash, itching, or excessive skin irritation, condition worsens, symptoms persist for >7 days

                  Previous
                  Next:

                  Pregnancy & Lactation

                  Pregnancy

                  See healthcare professional

                  Lactation

                  See healthcare professional

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

                  Previous
                  Next:

                  Pharmacology

                  Mechanism of Action

                  Active constituent, capsaicin, binds to neuronal transient potential vanilloid receptor 1 (TPRV1), depletes substance P; decreases pain perception

                  Previous
                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.