Ginger (Herb/Suppl)

Brand and Other Names:African ginger, black ginger, more...cochin ginger, Imber, Jamaica ginger, race ginger, rhizoma zingerberis, rhizome, sheng jiang, Shokyo, zingibain, Zingiber officinale, Zingiberis
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Suggested Dosing

Migraine Headache

500 mg PO q4hour PRN; no more than 1.5-2 g/d

Morning Sickness

250 mg PO QID or 500 mg PO BID

Motion Sickness (Powdered Root)

1 g PO 0.5-4 hours before travel

Nausea, Chemo-induced (Powdered Root)

1-4 g/d PO; no more than 4 g/d

Osteoarthritis (Extract)

170 mg PO TID OR

255 mg PO BID

No more than 4 g/d

SSRI Taper/Discontinuation

550-1100 mg PO TID; no more than 4 g/d

Other Information

Nausea/Vomiting of Pregnancy: 250 mg powder PO QID, may take up to 6 g/d

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Suggested Uses

Antiemetic, carminative, stimulant, anti-inflammatory

Dyspepsia, migraine headache, morning sickness, motion sickness, nausea (chemo-induced), nausea/vomiting (post-op), osteoarthritis, respiratory infections, rheumatoid arthritis, SSRI taper/discontinuation

Efficacy

Demonstrated antiemetic efficacy in pregnancy, postoperative nausea and vomiting and vertigo

Possibly ineffective for motion sickness

Insufficient reliable data to rate use in chemotherapy induced nausea and vomiting, migraine headache, osteoarthritis and rheumatoid arthritis

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Interactions

Interaction Checker

and Ginger

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (70)

                • aceclofenac

                  aceclofenac and ginger both increase anticoagulation. Use Caution/Monitor.

                • acemetacin

                  acemetacin and ginger both increase anticoagulation. Use Caution/Monitor.

                • agrimony

                  agrimony and ginger both increase anticoagulation. Use Caution/Monitor.

                • alfalfa

                  alfalfa and ginger both increase anticoagulation. Use Caution/Monitor.

                • alteplase

                  alteplase and ginger both increase anticoagulation. Use Caution/Monitor.

                • American ginseng

                  American ginseng and ginger both increase anticoagulation. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin and ginger both increase anticoagulation. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal and ginger both increase anticoagulation. Use Caution/Monitor.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and ginger both increase anticoagulation. Use Caution/Monitor.

                • bemiparin

                  bemiparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • bivalirudin

                  bivalirudin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib and ginger both increase anticoagulation. Use Caution/Monitor.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and ginger both increase anticoagulation. Use Caution/Monitor.

                • cinnamon

                  cinnamon and ginger both increase anticoagulation. Use Caution/Monitor.

                • cordyceps

                  cordyceps and ginger both increase anticoagulation. Use Caution/Monitor.

                • dabigatran

                  dabigatran and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • dalteparin

                  dalteparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • diclofenac

                  diclofenac and ginger both increase anticoagulation. Use Caution/Monitor.

                • diflunisal

                  diflunisal and ginger both increase anticoagulation. Use Caution/Monitor.

                • dong quai

                  dong quai and ginger both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • epoprostenol

                  epoprostenol and ginger both increase anticoagulation. Use Caution/Monitor.

                • etodolac

                  etodolac and ginger both increase anticoagulation. Use Caution/Monitor.

                • fennel

                  fennel and ginger both increase anticoagulation. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen and ginger both increase anticoagulation. Use Caution/Monitor.

                • feverfew

                  feverfew and ginger both increase anticoagulation. Use Caution/Monitor.

                • flurbiprofen

                  flurbiprofen and ginger both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • forskolin

                  forskolin and ginger both increase anticoagulation. Use Caution/Monitor.

                • garlic

                  garlic and ginger both increase anticoagulation. Use Caution/Monitor.

                • ginkgo biloba

                  ginger and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

                • heparin

                  heparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  ginger and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen and ginger both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV and ginger both increase anticoagulation. Use Caution/Monitor.

                • indomethacin

                  indomethacin and ginger both increase anticoagulation. Use Caution/Monitor.

                • ketoprofen

                  ketoprofen and ginger both increase anticoagulation. Use Caution/Monitor.

                • ketorolac

                  ketorolac and ginger both increase anticoagulation. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal and ginger both increase anticoagulation. Use Caution/Monitor.

                • lornoxicam

                  lornoxicam and ginger both increase anticoagulation. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate and ginger both increase anticoagulation. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid and ginger both increase anticoagulation. Use Caution/Monitor.

                • meloxicam

                  meloxicam and ginger both increase anticoagulation. Use Caution/Monitor.

                • mistletoe

                  ginger increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nabumetone

                  nabumetone and ginger both increase anticoagulation. Use Caution/Monitor.

                • naproxen

                  naproxen and ginger both increase anticoagulation. Use Caution/Monitor.

                • nettle

                  ginger increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin and ginger both increase anticoagulation. Use Caution/Monitor.

                • panax ginseng

                  ginger and panax ginseng both increase anticoagulation. Use Caution/Monitor.

                • parecoxib

                  parecoxib and ginger both increase anticoagulation. Use Caution/Monitor.

                • pau d'arco

                  ginger and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • phytoestrogens

                  ginger and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • piroxicam

                  piroxicam and ginger both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • reishi

                  ginger and reishi both increase anticoagulation. Use Caution/Monitor.

                • reteplase

                  reteplase and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • salicylates (non-asa)

                  salicylates (non-asa) and ginger both increase anticoagulation. Use Caution/Monitor.

                • salsalate

                  salsalate and ginger both increase anticoagulation. Use Caution/Monitor.

                • Siberian ginseng

                  ginger and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sulfasalazine

                  sulfasalazine and ginger both increase anticoagulation. Use Caution/Monitor.

                • sulindac

                  sulindac and ginger both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                • tolfenamic acid

                  tolfenamic acid and ginger both increase anticoagulation. Use Caution/Monitor.

                • tolmetin

                  tolmetin and ginger both increase anticoagulation. Use Caution/Monitor.

                • vitamin K1 (phytonadione)

                  ginger increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • warfarin

                  warfarin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.

                Minor (13)

                • abciximab

                  ginger, abciximab. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • anagrelide

                  ginger, anagrelide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • anamu

                  anamu and ginger both increase anticoagulation. Minor/Significance Unknown.

                • cilostazol

                  ginger, cilostazol. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • clopidogrel

                  ginger, clopidogrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • danshen

                  danshen and ginger both increase anticoagulation. Minor/Significance Unknown.

                • devil's claw

                  devil's claw and ginger both increase anticoagulation. Minor/Significance Unknown.

                • dipyridamole

                  ginger, dipyridamole. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • eptifibatide

                  ginger, eptifibatide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • green tea

                  green tea, ginger. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

                • prasugrel

                  ginger, prasugrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • ticlopidine

                  ginger, ticlopidine. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • tirofiban

                  ginger, tirofiban. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

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                Adverse Effects

                Frequency Not Defined

                May increase bleeding tendency

                Abdominal discomfort

                Cardiac arrhythmias (OD)

                CNS depression (OD)

                Dermatitis (topical use)

                Diarrhea

                Heartburn

                Mouth/throat irritation

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                Warnings

                Contraindications

                Hypersensitivity

                Gallbladder disease

                Cautions

                Bleeding disorders, cardiac disease, diabetes mellitus, hypertension, hypotension

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                Pregnancy & Lactation

                Pregnancy Category: not recommended by German Commission E; however, current data indicate safe when used at usual therapeutic dose

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Galanolactone: 5HT3 antagonist

                Inhibits prostaglandin and eicosanoid synthesis

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.