Indication-specific dosing for African ginger, black ginger, cochin ginger ginger in combination, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Ginger
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

Migraine Headache

500 mg PO q4hour PRN; no more than 1.5-2 g/d

Morning Sickness

250 mg PO QID or 500 mg PO BID

Motion Sickness (Powdered Root)

1 g PO 0.5-4 hours before travel

Nausea, Chemo-induced (Powdered Root)

1-4 g/d PO; no more than 4 g/d

Osteoarthritis (Extract)

170 mg PO TID OR

255 mg PO BID

No more than 4 g/d

SSRI Taper/Discontinuation

550-1100 mg PO TID; no more than 4 g/d

Other Information

Nausea/Vomiting of Pregnancy: 250 mg powder PO QID, may take up to 6 g/d

Suggested Uses

Antiemetic, carminative, stimulant, anti-inflammatory

Dyspepsia, migraine headache, morning sickness, motion sickness, nausea (chemo-induced), nausea/vomiting (post-op), osteoarthritis, respiratory infections, rheumatoid arthritis, SSRI taper/discontinuation

Efficacy

Demonstrated antiemetic efficacy in pregnancy, postoperative nausea and vomiting and vertigo

Possibly ineffective for motion sickness

Insufficient reliable data to rate use in chemotherapy induced nausea and vomiting, migraine headache, osteoarthritis and rheumatoid arthritis

Interaction Checker

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Contraindicated (0)

Serious - Use Alternative (0)

Monitor Closely (69)

aceclofenac
aceclofenac and ginger both increase anticoagulation. Use Caution/Monitor.
acemetacin
acemetacin and ginger both increase anticoagulation. Use Caution/Monitor.
agrimony
agrimony and ginger both increase anticoagulation. Use Caution/Monitor.
alfalfa
alfalfa and ginger both increase anticoagulation. Use Caution/Monitor.
alteplase
alteplase and ginger both increase anticoagulation. Use Caution/Monitor.
American ginseng
American ginseng and ginger both increase anticoagulation. Use Caution/Monitor.
antithrombin alfa
antithrombin alfa and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
antithrombin III
antithrombin III and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
argatroban
argatroban and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
aspirin
aspirin and ginger both increase anticoagulation. Use Caution/Monitor.
aspirin rectal
aspirin rectal and ginger both increase anticoagulation. Use Caution/Monitor.
aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate and ginger both increase anticoagulation. Use Caution/Monitor.
bemiparin
bemiparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
bivalirudin
bivalirudin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
celecoxib
celecoxib and ginger both increase anticoagulation. Use Caution/Monitor.
choline magnesium trisalicylate
choline magnesium trisalicylate and ginger both increase anticoagulation. Use Caution/Monitor.
cinnamon
cinnamon and ginger both increase anticoagulation. Use Caution/Monitor.
cordyceps
cordyceps and ginger both increase anticoagulation. Use Caution/Monitor.
dabigatran
dabigatran and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
dalteparin
dalteparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
diclofenac
diclofenac and ginger both increase anticoagulation. Use Caution/Monitor.
diflunisal
diflunisal and ginger both increase anticoagulation. Use Caution/Monitor.
dong quai
dong quai and ginger both increase anticoagulation. Use Caution/Monitor.
enoxaparin
enoxaparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
epoprostenol
epoprostenol and ginger both increase anticoagulation. Use Caution/Monitor.
etodolac
etodolac and ginger both increase anticoagulation. Use Caution/Monitor.
fennel
fennel and ginger both increase anticoagulation. Use Caution/Monitor.
fenoprofen
fenoprofen and ginger both increase anticoagulation. Use Caution/Monitor.
feverfew
feverfew and ginger both increase anticoagulation. Use Caution/Monitor.
flurbiprofen
flurbiprofen and ginger both increase anticoagulation. Use Caution/Monitor.
fondaparinux
fondaparinux and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
forskolin
forskolin and ginger both increase anticoagulation. Use Caution/Monitor.
garlic
garlic and ginger both increase anticoagulation. Use Caution/Monitor.
ginkgo biloba
ginger and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.
heparin
heparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
horse chestnut seed
ginger and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.
ibuprofen
ibuprofen and ginger both increase anticoagulation. Use Caution/Monitor.
ibuprofen IV
ibuprofen IV and ginger both increase anticoagulation. Use Caution/Monitor.
indomethacin
indomethacin and ginger both increase anticoagulation. Use Caution/Monitor.
ketoprofen
ketoprofen and ginger both increase anticoagulation. Use Caution/Monitor.
ketorolac
ketorolac and ginger both increase anticoagulation. Use Caution/Monitor.
ketorolac intranasal
ketorolac intranasal and ginger both increase anticoagulation. Use Caution/Monitor.
lornoxicam
lornoxicam and ginger both increase anticoagulation. Use Caution/Monitor.
meclofenamate
meclofenamate and ginger both increase anticoagulation. Use Caution/Monitor.
mefenamic acid
mefenamic acid and ginger both increase anticoagulation. Use Caution/Monitor.
meloxicam
meloxicam and ginger both increase anticoagulation. Use Caution/Monitor.
mistletoe
ginger increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nabumetone
nabumetone and ginger both increase anticoagulation. Use Caution/Monitor.
naproxen
naproxen and ginger both increase anticoagulation. Use Caution/Monitor.
nettle
ginger increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
oxaprozin
oxaprozin and ginger both increase anticoagulation. Use Caution/Monitor.
panax ginseng
ginger and panax ginseng both increase anticoagulation. Use Caution/Monitor.
parecoxib
parecoxib and ginger both increase anticoagulation. Use Caution/Monitor.
pau d'arco
ginger and pau d'arco both increase anticoagulation. Use Caution/Monitor.
phenindione
phenindione and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
phytoestrogens
ginger and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
piroxicam
piroxicam and ginger both increase anticoagulation. Use Caution/Monitor.
protamine
protamine and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
reishi
ginger and reishi both increase anticoagulation. Use Caution/Monitor.
reteplase
reteplase and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
salicylates (non-asa)
salicylates (non-asa) and ginger both increase anticoagulation. Use Caution/Monitor.
salsalate
salsalate and ginger both increase anticoagulation. Use Caution/Monitor.
Siberian ginseng
ginger and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
sulfasalazine
sulfasalazine and ginger both increase anticoagulation. Use Caution/Monitor.
sulindac
sulindac and ginger both increase anticoagulation. Use Caution/Monitor.
tenecteplase
tenecteplase and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
tolfenamic acid
tolfenamic acid and ginger both increase anticoagulation. Use Caution/Monitor.
tolmetin
tolmetin and ginger both increase anticoagulation. Use Caution/Monitor.
vitamin K1 (phytonadione)
ginger increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

Minor (13)

abciximab
ginger, abciximab. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
anagrelide
ginger, anagrelide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
anamu
anamu and ginger both increase anticoagulation. Minor/Significance Unknown.
cilostazol
ginger, cilostazol. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
clopidogrel
ginger, clopidogrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
danshen
danshen and ginger both increase anticoagulation. Minor/Significance Unknown.
devil's claw
devil's claw and ginger both increase anticoagulation. Minor/Significance Unknown.
dipyridamole
ginger, dipyridamole. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
eptifibatide
ginger, eptifibatide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
green tea
green tea, ginger. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.
prasugrel
ginger, prasugrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
ticlopidine
ginger, ticlopidine. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
tirofiban
ginger, tirofiban. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

abciximab
Minor (1)ginger, abciximab. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
aceclofenac
Monitor Closely (1)aceclofenac and ginger both increase anticoagulation. Use Caution/Monitor.
acemetacin
Monitor Closely (1)acemetacin and ginger both increase anticoagulation. Use Caution/Monitor.
agrimony
Monitor Closely (1)agrimony and ginger both increase anticoagulation. Use Caution/Monitor.
alfalfa
Monitor Closely (1)alfalfa and ginger both increase anticoagulation. Use Caution/Monitor.
alteplase
Monitor Closely (1)alteplase and ginger both increase anticoagulation. Use Caution/Monitor.
American ginseng
Monitor Closely (1)American ginseng and ginger both increase anticoagulation. Use Caution/Monitor.
anagrelide
Minor (1)ginger, anagrelide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
anamu
Minor (1)anamu and ginger both increase anticoagulation. Minor/Significance Unknown.
antithrombin alfa
Monitor Closely (1)antithrombin alfa and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
antithrombin III
Monitor Closely (1)antithrombin III and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
argatroban
Monitor Closely (1)argatroban and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
aspirin
Monitor Closely (1)aspirin and ginger both increase anticoagulation. Use Caution/Monitor.
aspirin rectal
Monitor Closely (1)aspirin rectal and ginger both increase anticoagulation. Use Caution/Monitor.
aspirin/citric acid/sodium bicarbonate
Monitor Closely (1)aspirin/citric acid/sodium bicarbonate and ginger both increase anticoagulation. Use Caution/Monitor.
bemiparin
Monitor Closely (1)bemiparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
bivalirudin
Monitor Closely (1)bivalirudin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
celecoxib
Monitor Closely (1)celecoxib and ginger both increase anticoagulation. Use Caution/Monitor.
choline magnesium trisalicylate
Monitor Closely (1)choline magnesium trisalicylate and ginger both increase anticoagulation. Use Caution/Monitor.
cilostazol
Minor (1)ginger, cilostazol. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
cinnamon
Monitor Closely (1)cinnamon and ginger both increase anticoagulation. Use Caution/Monitor.
clopidogrel
Minor (1)ginger, clopidogrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
cordyceps
Monitor Closely (1)cordyceps and ginger both increase anticoagulation. Use Caution/Monitor.
dabigatran
Monitor Closely (1)dabigatran and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
dalteparin
Monitor Closely (1)dalteparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
danshen
Minor (1)danshen and ginger both increase anticoagulation. Minor/Significance Unknown.
devil's claw
Minor (1)devil's claw and ginger both increase anticoagulation. Minor/Significance Unknown.
diclofenac
Monitor Closely (1)diclofenac and ginger both increase anticoagulation. Use Caution/Monitor.
diflunisal
Monitor Closely (1)diflunisal and ginger both increase anticoagulation. Use Caution/Monitor.
dipyridamole
Minor (1)ginger, dipyridamole. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
dong quai
Monitor Closely (1)dong quai and ginger both increase anticoagulation. Use Caution/Monitor.
enoxaparin
Monitor Closely (1)enoxaparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
epoprostenol
Monitor Closely (1)epoprostenol and ginger both increase anticoagulation. Use Caution/Monitor.
eptifibatide
Minor (1)ginger, eptifibatide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
etodolac
Monitor Closely (1)etodolac and ginger both increase anticoagulation. Use Caution/Monitor.
fennel
Monitor Closely (1)fennel and ginger both increase anticoagulation. Use Caution/Monitor.
fenoprofen
Monitor Closely (1)fenoprofen and ginger both increase anticoagulation. Use Caution/Monitor.
feverfew
Monitor Closely (1)feverfew and ginger both increase anticoagulation. Use Caution/Monitor.
flurbiprofen
Monitor Closely (1)flurbiprofen and ginger both increase anticoagulation. Use Caution/Monitor.
fondaparinux
Monitor Closely (1)fondaparinux and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
forskolin
Monitor Closely (1)forskolin and ginger both increase anticoagulation. Use Caution/Monitor.
garlic
Monitor Closely (1)garlic and ginger both increase anticoagulation. Use Caution/Monitor.
ginkgo biloba
Monitor Closely (1)ginger and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.
green tea
Minor (1)green tea, ginger. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.
heparin
Monitor Closely (1)heparin and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
horse chestnut seed
Monitor Closely (1)ginger and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.
ibuprofen
Monitor Closely (1)ibuprofen and ginger both increase anticoagulation. Use Caution/Monitor.
ibuprofen IV
Monitor Closely (1)ibuprofen IV and ginger both increase anticoagulation. Use Caution/Monitor.
indomethacin
Monitor Closely (1)indomethacin and ginger both increase anticoagulation. Use Caution/Monitor.
ketoprofen
Monitor Closely (1)ketoprofen and ginger both increase anticoagulation. Use Caution/Monitor.
ketorolac
Monitor Closely (1)ketorolac and ginger both increase anticoagulation. Use Caution/Monitor.
ketorolac intranasal
Monitor Closely (1)ketorolac intranasal and ginger both increase anticoagulation. Use Caution/Monitor.
lornoxicam
Monitor Closely (1)lornoxicam and ginger both increase anticoagulation. Use Caution/Monitor.
meclofenamate
Monitor Closely (1)meclofenamate and ginger both increase anticoagulation. Use Caution/Monitor.
mefenamic acid
Monitor Closely (1)mefenamic acid and ginger both increase anticoagulation. Use Caution/Monitor.
meloxicam
Monitor Closely (1)meloxicam and ginger both increase anticoagulation. Use Caution/Monitor.
mistletoe
Monitor Closely (1)ginger increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nabumetone
Monitor Closely (1)nabumetone and ginger both increase anticoagulation. Use Caution/Monitor.
naproxen
Monitor Closely (1)naproxen and ginger both increase anticoagulation. Use Caution/Monitor.
nettle
Monitor Closely (1)ginger increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
oxaprozin
Monitor Closely (1)oxaprozin and ginger both increase anticoagulation. Use Caution/Monitor.
panax ginseng
Monitor Closely (1)ginger and panax ginseng both increase anticoagulation. Use Caution/Monitor.
parecoxib
Monitor Closely (1)parecoxib and ginger both increase anticoagulation. Use Caution/Monitor.
pau d'arco
Monitor Closely (1)ginger and pau d'arco both increase anticoagulation. Use Caution/Monitor.
phenindione
Monitor Closely (1)phenindione and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
phytoestrogens
Monitor Closely (1)ginger and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
piroxicam
Monitor Closely (1)piroxicam and ginger both increase anticoagulation. Use Caution/Monitor.
prasugrel
Minor (1)ginger, prasugrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
protamine
Monitor Closely (1)protamine and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
reishi
Monitor Closely (1)ginger and reishi both increase anticoagulation. Use Caution/Monitor.
reteplase
Monitor Closely (1)reteplase and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
salicylates (non-asa)
Monitor Closely (1)salicylates (non-asa) and ginger both increase anticoagulation. Use Caution/Monitor.
salsalate
Monitor Closely (1)salsalate and ginger both increase anticoagulation. Use Caution/Monitor.
Siberian ginseng
Monitor Closely (1)ginger and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
sulfasalazine
Monitor Closely (1)sulfasalazine and ginger both increase anticoagulation. Use Caution/Monitor.
sulindac
Monitor Closely (1)sulindac and ginger both increase anticoagulation. Use Caution/Monitor.
tenecteplase
Monitor Closely (1)tenecteplase and ginger both increase anticoagulation. Modify Therapy/Monitor Closely.
ticlopidine
Minor (1)ginger, ticlopidine. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
tirofiban
Minor (1)ginger, tirofiban. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.
tolfenamic acid
Monitor Closely (1)tolfenamic acid and ginger both increase anticoagulation. Use Caution/Monitor.
tolmetin
Monitor Closely (1)tolmetin and ginger both increase anticoagulation. Use Caution/Monitor.
vitamin K1 (phytonadione)
Monitor Closely (1)ginger increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

Frequency Not Defined

May increase bleeding tendency

Abdominal discomfort

Cardiac arrhythmias (OD)

CNS depression (OD)

Dermatitis (topical use)

Diarrhea

Heartburn

Mouth/throat irritation

Contraindications

Hypersensitivity

Gallbladder disease

Cautions

Bleeding disorders, cardiac disease, diabetes mellitus, hypertension, hypotension

Pregnancy & Lactation

Pregnancy Category: not recommended by German Commission E; however, current data indicate safe when used at usual therapeutic dose

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Galanolactone: 5HT3 antagonist

Inhibits prostaglandin and eicosanoid synthesis

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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