Devil's Claw (Herb/Suppl)

Brand and Other Names:afrikanische teufelskralle, ao ao, more...arpagofito, Arthrosetten H, Arthrotabsm, artiglio del diavolo, Artosan, Defencid, Doloteffin, duiwelsklou, ekatata, elyata, grapple plant, griffe du diable, Hariosen, Harpadol, HarpagoMega, harpagon, harpagophytum procumbens, harpagoside, Jucurba N, khams, khuripe, klaudoring, likakata, otjihangatene, RheumaSern, RheumaTee, Salus, sengaparile, Sudafrikanische Teufelskralle, Trampelklette, Venustorn, windhoek's root, wood spider, xemta'eisa
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Suggested Dosing

Osteoarthritis/Low Back Pain

Crude Extract: 2-9 g/d PO

Standardized Tablets: 600-1200 mg (=50-100 mg harpagoside) PO TID

Other Information

Anorexia: 1.5 g/day decoction

Elixir (1:1): 0.1-0.25 mL PO TID

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Suggested Uses

Osteoarthritis, lower back pain, appetite loss, cancer pain

Efficacy

Increasing evidence of short-term benefit in osteoarthritis; some evidence of benefit in lower back pain; unclear with regards to other uses

Extensively used in Europe for mild joint pain

German Commission E approves the use of Devil's claw root for:

  • Appetite loss, dyspepsia, supportive therapy for arthritis

ESCOP approves the use of Devil's claw root for:

  • Painful arthrosis, tendinitis, appetite loss, dyspepsia
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Interactions

Interaction Checker

and Devil's Claw

No Results

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (16)

                • alteplase

                  alteplase and devil's claw both increase anticoagulation. Use Caution/Monitor. Devil's claw may have additive anticoagulant activity.

                • antithrombin alfa

                  antithrombin alfa and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • antithrombin III

                  antithrombin III and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • argatroban

                  argatroban and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • bemiparin

                  bemiparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • bivalirudin

                  bivalirudin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • dabigatran

                  dabigatran and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • dalteparin

                  dalteparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • heparin

                  heparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • reteplase

                  reteplase and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and devil's claw both increase anticoagulation. Use Caution/Monitor.

                • warfarin

                  warfarin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                Minor (102)

                • abciximab

                  devil's claw, abciximab. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • acarbose

                  devil's claw increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown.

                • aceclofenac

                  aceclofenac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • acemetacin

                  acemetacin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • agrimony

                  agrimony and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • alfalfa

                  alfalfa and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • aluminum hydroxide

                  devil's claw decreases effects of aluminum hydroxide by pharmacodynamic antagonism. Minor/Significance Unknown.

                • American ginseng

                  American ginseng and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • anagrelide

                  devil's claw, anagrelide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • anamu

                  anamu and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • aspirin

                  aspirin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • aspirin rectal

                  aspirin rectal and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • calcium carbonate

                  devil's claw decreases effects of calcium carbonate by pharmacodynamic antagonism. Minor/Significance Unknown.

                • celecoxib

                  celecoxib and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • chlorpropamide

                  devil's claw increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • cilostazol

                  devil's claw, cilostazol. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                • cimetidine

                  devil's claw decreases effects of cimetidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • cinnamon

                  cinnamon and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • clopidogrel

                  devil's claw, clopidogrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                • cordyceps

                  cordyceps and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • danshen

                  danshen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • dexlansoprazole

                  devil's claw decreases effects of dexlansoprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                • diclofenac

                  diclofenac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • diflunisal

                  diflunisal and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • dipyridamole

                  devil's claw, dipyridamole. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                • dong quai

                  devil's claw and dong quai both increase anticoagulation. Minor/Significance Unknown.

                • epoprostenol

                  devil's claw and epoprostenol both increase anticoagulation. Minor/Significance Unknown.

                • eptifibatide

                  devil's claw, eptifibatide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                • esomeprazole

                  devil's claw decreases effects of esomeprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                • etodolac

                  etodolac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • famotidine

                  devil's claw decreases effects of famotidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • fennel

                  devil's claw and fennel both increase anticoagulation. Minor/Significance Unknown.

                • fenoprofen

                  fenoprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • feverfew

                  devil's claw and feverfew both increase anticoagulation. Minor/Significance Unknown.

                • flurbiprofen

                  flurbiprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • forskolin

                  devil's claw and forskolin both increase anticoagulation. Minor/Significance Unknown.

                • garlic

                  devil's claw and garlic both increase anticoagulation. Minor/Significance Unknown.

                • ginger

                  devil's claw and ginger both increase anticoagulation. Minor/Significance Unknown.

                • ginkgo biloba

                  devil's claw and ginkgo biloba both increase anticoagulation. Minor/Significance Unknown.

                • glimepiride

                  devil's claw increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.

                • glipizide

                  devil's claw increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.

                • glyburide

                  devil's claw increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.

                • horse chestnut seed

                  devil's claw and horse chestnut seed both increase anticoagulation. Minor/Significance Unknown.

                • ibuprofen

                  ibuprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • ibuprofen IV

                  ibuprofen IV and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • ibuprofen/famotidine

                  devil's claw decreases effects of ibuprofen/famotidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • indomethacin

                  indomethacin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • insulin aspart

                  devil's claw increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin detemir

                  devil's claw increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin glargine

                  devil's claw increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin glulisine

                  devil's claw increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin lispro

                  devil's claw increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin NPH

                  devil's claw increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.

                • insulin regular human

                  devil's claw increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.

                • ketoprofen

                  ketoprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • ketorolac

                  ketorolac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • ketorolac intranasal

                  ketorolac intranasal and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • lansoprazole

                  devil's claw decreases effects of lansoprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                • lornoxicam

                  lornoxicam and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • meclofenamate

                  meclofenamate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • mefenamic acid

                  mefenamic acid and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • meloxicam

                  meloxicam and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • metformin

                  devil's claw increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown.

                • miglitol

                  devil's claw increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown.

                • mistletoe

                  devil's claw increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • nabumetone

                  nabumetone and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • naproxen

                  naproxen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • nateglinide

                  devil's claw increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                • nettle

                  devil's claw increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • nizatidine

                  devil's claw decreases effects of nizatidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • omeprazole

                  devil's claw decreases effects of omeprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                • oxaprozin

                  oxaprozin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • panax ginseng

                  devil's claw and panax ginseng both increase anticoagulation. Minor/Significance Unknown.

                • pantoprazole

                  devil's claw decreases effects of pantoprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                • parecoxib

                  parecoxib and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • pau d'arco

                  devil's claw and pau d'arco both increase anticoagulation. Minor/Significance Unknown.

                • phytoestrogens

                  devil's claw and phytoestrogens both increase anticoagulation. Minor/Significance Unknown.

                • pioglitazone

                  devil's claw increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                • piroxicam

                  piroxicam and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • prasugrel

                  devil's claw, prasugrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • rabeprazole

                  devil's claw decreases effects of rabeprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                • reishi

                  devil's claw and reishi both increase anticoagulation. Minor/Significance Unknown.

                • repaglinide

                  devil's claw increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                • rosiglitazone

                  devil's claw increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                • salicylates (non-asa)

                  salicylates (non-asa) and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • salsalate

                  salsalate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • saxagliptin

                  devil's claw increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                • Siberian ginseng

                  devil's claw and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.

                • sitagliptin

                  devil's claw increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                • sodium bicarbonate

                  devil's claw decreases effects of sodium bicarbonate by pharmacodynamic antagonism. Minor/Significance Unknown.

                • sodium citrate/citric acid

                  devil's claw decreases effects of sodium citrate/citric acid by pharmacodynamic antagonism. Minor/Significance Unknown.

                • sulfasalazine

                  sulfasalazine and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • sulindac

                  sulindac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • ticlopidine

                  devil's claw, ticlopidine. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • tirofiban

                  devil's claw, tirofiban. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                • tolazamide

                  devil's claw increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown.

                • tolbutamide

                  devil's claw increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown.

                • tolfenamic acid

                  tolfenamic acid and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • tolmetin

                  tolmetin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                • vildagliptin

                  devil's claw increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

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                Adverse Effects

                Generally well-tolerated

                Headache, GI upset, bradycardia, taste loss

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                Warnings

                Cautions

                Stomach or intestinal ulcer, diabetes, high or low blood pressure, arrhythmia

                Safety/efficacy not established for children

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Unclear; one study found correlation between serum harpagoside levels & leukotriene biosynthesis inhibition; harpagoside may also have analgesic actions

                May also have anti-oxidant effects

                Constituents include iridoid glucosides (eg, harpagoside), phytosterols, & flavonoids

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.