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      Drugs & Diseases

      Devil's Claw (Herb/Suppl)

      Brand and Other Names:afrikanische teufelskralle, ao ao, more...arpagofito, Arthrosetten H, Arthrotabsm, artiglio del diavolo, Artosan, Defencid, Doloteffin, duiwelsklou, ekatata, elyata, grapple plant, griffe du diable, Hariosen, Harpadol, HarpagoMega, harpagon, harpagophytum procumbens, harpagoside, Jucurba N, khams, khuripe, klaudoring, likakata, otjihangatene, RheumaSern, RheumaTee, Salus, sengaparile, Sudafrikanische Teufelskralle, Trampelklette, Venustorn, windhoek's root, wood spider, xemta'eisa
      • Print

      Suggested Dosing

      Osteoarthritis/Low Back Pain

      Crude Extract: 2-9 g/d PO

      Standardized Tablets: 600-1200 mg (=50-100 mg harpagoside) PO TID

      Other Information

      Anorexia: 1.5 g/day decoction

      Elixir (1:1): 0.1-0.25 mL PO TID

      Next:

      Suggested Uses

      Osteoarthritis, lower back pain, appetite loss, cancer pain

      Efficacy

      Increasing evidence of short-term benefit in osteoarthritis; some evidence of benefit in lower back pain; unclear with regards to other uses

      Extensively used in Europe for mild joint pain

      German Commission E approves the use of Devil's claw root for:

      • Appetite loss, dyspepsia, supportive therapy for arthritis

      ESCOP approves the use of Devil's claw root for:

      • Painful arthrosis, tendinitis, appetite loss, dyspepsia
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      Interactions

      Interaction Checker

      and Devil's Claw

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

              Minor

                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (0)

                    Monitor Closely (15)

                    • alteplase

                      alteplase and devil's claw both increase anticoagulation. Use Caution/Monitor. Devil's claw may have additive anticoagulant activity.

                    • antithrombin alfa

                      antithrombin alfa and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • antithrombin III

                      antithrombin III and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • argatroban

                      argatroban and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • bemiparin

                      bemiparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • bivalirudin

                      bivalirudin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • dabigatran

                      dabigatran and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • dalteparin

                      dalteparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • enoxaparin

                      enoxaparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • fondaparinux

                      fondaparinux and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • heparin

                      heparin and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • phenindione

                      phenindione and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • protamine

                      protamine and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • reteplase

                      reteplase and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    • tenecteplase

                      tenecteplase and devil's claw both increase anticoagulation. Use Caution/Monitor.

                    Minor (102)

                    • abciximab

                      devil's claw, abciximab. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                    • acarbose

                      devil's claw increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown.

                    • aceclofenac

                      aceclofenac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • acemetacin

                      acemetacin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • agrimony

                      agrimony and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • alfalfa

                      alfalfa and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • aluminum hydroxide

                      devil's claw decreases effects of aluminum hydroxide by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • American ginseng

                      American ginseng and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • anagrelide

                      devil's claw, anagrelide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                    • anamu

                      anamu and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • aspirin

                      aspirin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • aspirin rectal

                      aspirin rectal and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • aspirin/citric acid/sodium bicarbonate

                      aspirin/citric acid/sodium bicarbonate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • calcium carbonate

                      devil's claw decreases effects of calcium carbonate by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • celecoxib

                      celecoxib and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • chlorpropamide

                      devil's claw increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • choline magnesium trisalicylate

                      choline magnesium trisalicylate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • cilostazol

                      devil's claw, cilostazol. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                    • cimetidine

                      devil's claw decreases effects of cimetidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • cinnamon

                      cinnamon and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • clopidogrel

                      devil's claw, clopidogrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                    • cordyceps

                      cordyceps and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • danshen

                      danshen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • dexlansoprazole

                      devil's claw decreases effects of dexlansoprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • diclofenac

                      diclofenac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • diflunisal

                      diflunisal and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • dipyridamole

                      devil's claw, dipyridamole. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                    • dong quai

                      devil's claw and dong quai both increase anticoagulation. Minor/Significance Unknown.

                    • epoprostenol

                      devil's claw and epoprostenol both increase anticoagulation. Minor/Significance Unknown.

                    • eptifibatide

                      devil's claw, eptifibatide. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence.ÿ Use with caution.

                    • esomeprazole

                      devil's claw decreases effects of esomeprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • etodolac

                      etodolac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • famotidine

                      devil's claw decreases effects of famotidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • fennel

                      devil's claw and fennel both increase anticoagulation. Minor/Significance Unknown.

                    • fenoprofen

                      fenoprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • feverfew

                      devil's claw and feverfew both increase anticoagulation. Minor/Significance Unknown.

                    • flurbiprofen

                      flurbiprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • forskolin

                      devil's claw and forskolin both increase anticoagulation. Minor/Significance Unknown.

                    • garlic

                      devil's claw and garlic both increase anticoagulation. Minor/Significance Unknown.

                    • ginger

                      devil's claw and ginger both increase anticoagulation. Minor/Significance Unknown.

                    • ginkgo biloba

                      devil's claw and ginkgo biloba both increase anticoagulation. Minor/Significance Unknown.

                    • glimepiride

                      devil's claw increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.

                    • glipizide

                      devil's claw increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • glyburide

                      devil's claw increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • horse chestnut seed

                      devil's claw and horse chestnut seed both increase anticoagulation. Minor/Significance Unknown.

                    • ibuprofen

                      ibuprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • ibuprofen IV

                      ibuprofen IV and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • ibuprofen/famotidine

                      devil's claw decreases effects of ibuprofen/famotidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • indomethacin

                      indomethacin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • insulin aspart

                      devil's claw increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin detemir

                      devil's claw increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin glargine

                      devil's claw increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin glulisine

                      devil's claw increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin lispro

                      devil's claw increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin NPH

                      devil's claw increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.

                    • insulin regular human

                      devil's claw increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.

                    • ketoprofen

                      ketoprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • ketorolac

                      ketorolac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • ketorolac intranasal

                      ketorolac intranasal and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • lansoprazole

                      devil's claw decreases effects of lansoprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • lornoxicam

                      lornoxicam and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • meclofenamate

                      meclofenamate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • mefenamic acid

                      mefenamic acid and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • meloxicam

                      meloxicam and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • metformin

                      devil's claw increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown.

                    • miglitol

                      devil's claw increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown.

                    • mistletoe

                      devil's claw increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • nabumetone

                      nabumetone and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • naproxen

                      naproxen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • nateglinide

                      devil's claw increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • nettle

                      devil's claw increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                    • nizatidine

                      devil's claw decreases effects of nizatidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • omeprazole

                      devil's claw decreases effects of omeprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • oxaprozin

                      oxaprozin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • panax ginseng

                      devil's claw and panax ginseng both increase anticoagulation. Minor/Significance Unknown.

                    • pantoprazole

                      devil's claw decreases effects of pantoprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • parecoxib

                      parecoxib and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • pau d'arco

                      devil's claw and pau d'arco both increase anticoagulation. Minor/Significance Unknown.

                    • phytoestrogens

                      devil's claw and phytoestrogens both increase anticoagulation. Minor/Significance Unknown.

                    • pioglitazone

                      devil's claw increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                    • piroxicam

                      piroxicam and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • prasugrel

                      devil's claw, prasugrel. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                    • rabeprazole

                      devil's claw decreases effects of rabeprazole by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • reishi

                      devil's claw and reishi both increase anticoagulation. Minor/Significance Unknown.

                    • repaglinide

                      devil's claw increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • rosiglitazone

                      devil's claw increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown.

                    • salicylates (non-asa)

                      salicylates (non-asa) and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • salsalate

                      salsalate and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • saxagliptin

                      devil's claw increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                    • Siberian ginseng

                      devil's claw and Siberian ginseng both increase anticoagulation. Minor/Significance Unknown.

                    • sitagliptin

                      devil's claw increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                    • sodium bicarbonate

                      devil's claw decreases effects of sodium bicarbonate by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • sodium citrate/citric acid

                      devil's claw decreases effects of sodium citrate/citric acid by pharmacodynamic antagonism. Minor/Significance Unknown.

                    • sulfasalazine

                      sulfasalazine and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • sulindac

                      sulindac and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • ticlopidine

                      devil's claw, ticlopidine. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                    • tirofiban

                      devil's claw, tirofiban. pharmacodynamic synergism. Minor/Significance Unknown. May prolong bleeding time. Conflicting evidence. Use with caution.

                    • tolazamide

                      devil's claw increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • tolbutamide

                      devil's claw increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown.

                    • tolfenamic acid

                      tolfenamic acid and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • tolmetin

                      tolmetin and devil's claw both increase anticoagulation. Minor/Significance Unknown.

                    • vildagliptin

                      devil's claw increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown.

                    Previous
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                    Adverse Effects

                    Generally well-tolerated

                    Headache, GI upset, bradycardia, taste loss

                    Previous
                    Next:

                    Warnings

                    Cautions

                    Stomach or intestinal ulcer, diabetes, high or low blood pressure, arrhythmia

                    Safety/efficacy not established for children

                    Previous
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                    Pregnancy & Lactation

                    Pregnancy Category: N/A

                    Lactation: N/A

                    Pregnancy Categories

                    A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                    B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                    C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                    D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                    X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                    NA: Information not available.

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                    Pharmacology

                    Metabolism: N/A

                    Excretion: N/A

                    Mechanism of Action

                    Unclear; one study found correlation between serum harpagoside levels & leukotriene biosynthesis inhibition; harpagoside may also have analgesic actions

                    May also have anti-oxidant effects

                    Constituents include iridoid glucosides (eg, harpagoside), phytosterols, & flavonoids

                    Previous
                    Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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