oxymetazoline intranasal (OTC)

Brand and Other Names:Afrin, Duramist Plus, more...Dristan 12 Hr, Cheracol Nasal, Duration, Genasal, QlearQuil 12 Hour Nasal Decongestant Moisturizing Spray, Sinarest 12 Hour, Vicks Sinex 12 Hour
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

intranasal solution

  • 0.05%

Nasal Congestion

Indicated for temporary relief of nasal congestion

2-3 gtt/sprays per nostril q12hr

Not to exceed 2 doses/24 hr for 3-5 days

Dosage Forms & Strengths

intranasal solution

  • 0.05%

Nasal Congestion

Indicated for temporary relief of nasal congestion

<6 years

  • Safety and efficacy not established

≥6 years

  • 2-3 gtt/sprays per nostril q12hr
  • Not to exceed 2 doses/24 hr for 3-5 days
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Interactions

Interaction Checker

and oxymetazoline intranasal

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Insomnia

            Headache

            Burning

            Stinging

            Dryness

            Sneezing

            Rebound congestion

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            May cause temporary discomfort, including burning, sneezing, singing, or increased nasal discharge

            Prolonged or frequent use may cause nasal congestion to recur or worsen

            Use caution in patients with hypertension or heart disease

            Use caution in patients with diabetes mellitus

            Use caution in patients with thyroid disease

            Use caution in patients with prostatic hyperplasia and/or genitourinary obstruction

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Not known if excreted in breast milk

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Alpha-adrenergic agonist; stimulates alpha-adrenergic receptors and produces vasoconstriction in the arterioles of the nasal mucosa

            Absorption

            Onset: Within seconds

            Duration: 6 hr

            Elimination

            Excretion: Via kidney

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.