Dosing & Uses
Dosage Forms & Strengths
intranasal solution
- 0.05%
Nasal Congestion
Indicated for temporary relief of nasal congestion
2-3 gtt/sprays per nostril q12hr
Not to exceed 2 doses/24 hr for 3-5 days
Dosage Forms & Strengths
intranasal solution
- 0.05%
Nasal Congestion
Indicated for temporary relief of nasal congestion
<6 years
- Safety and efficacy not established
≥6 years
- 2-3 gtt/sprays per nostril q12hr
- Not to exceed 2 doses/24 hr for 3-5 days
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
Frequency Not Defined
Insomnia
Headache
Burning
Stinging
Dryness
Sneezing
Rebound congestion
Warnings
Contraindications
Hypersensitivity
Cautions
May cause temporary discomfort, including burning, sneezing, singing, or increased nasal discharge
Prolonged or frequent use may cause nasal congestion to recur or worsen
Use caution in patients with hypertension or heart disease
Use caution in patients with diabetes mellitus
Use caution in patients with thyroid disease
Use caution in patients with prostatic hyperplasia and/or genitourinary obstruction
Pregnancy & Lactation
Pregnancy category: C
Lactation: Not known if excreted in breast milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Alpha-adrenergic agonist; stimulates alpha-adrenergic receptors and produces vasoconstriction in the arterioles of the nasal mucosa
Absorption
Onset: Within seconds
Duration: 6 hr
Elimination
Excretion: Via kidney
