Garlic (Herb/Suppl)

Brand and Other Names:ail, ajo, more...Allium sativum, camphor of the poor, da-suan, knoblauch, la-suan, nectar of the Gods, poor man's treacle, rust treacle, stinking rose
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Suggested Dosing

Oral

Standardized extract

  • 200-400 mg PO TID

Aged extract

  • 600-7200 mg/d PO

Fresh

  • 4 g (approx 1 clove) PO qD

Topical (Liquefied raw Garlic or Extract)

Apply to affected area TID

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Suggested Uses

CAD (prevention), cancer (prevention), circulation (enhancement), Helicobacter pylori infection, hyperlipidemia, hypertension, immunostimulant, menstrual disorders, tick repellant, tinea infections

Efficacy

Some conflicting data on serum lipid reduction; overall shown to be "modestly" effective in decreasing serum cholesterol

Demonstrated to lower systolic & diastolic BP

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Interactions

Interaction Checker

and Garlic

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (80)

                • aceclofenac

                  aceclofenac and garlic both increase anticoagulation. Use Caution/Monitor.

                • acemetacin

                  acemetacin and garlic both increase anticoagulation. Use Caution/Monitor.

                • agrimony

                  agrimony and garlic both increase anticoagulation. Use Caution/Monitor.

                • alfalfa

                  alfalfa and garlic both increase anticoagulation. Use Caution/Monitor.

                • alteplase

                  alteplase and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • American ginseng

                  American ginseng and garlic both increase anticoagulation. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin and garlic both increase anticoagulation. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal and garlic both increase anticoagulation. Use Caution/Monitor.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and garlic both increase anticoagulation. Use Caution/Monitor.

                • atazanavir

                  garlic decreases levels of atazanavir by unknown mechanism. Use Caution/Monitor.

                • bemiparin

                  bemiparin and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • betrixaban

                  garlic, betrixaban. Either increases levels of the other by anticoagulation. Use Caution/Monitor.

                • bivalirudin

                  bivalirudin and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib and garlic both increase anticoagulation. Use Caution/Monitor.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and garlic both increase anticoagulation. Use Caution/Monitor.

                • cinnamon

                  cinnamon and garlic both increase anticoagulation. Use Caution/Monitor.

                • cordyceps

                  cordyceps and garlic both increase anticoagulation. Use Caution/Monitor.

                • dabigatran

                  dabigatran and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • dalteparin

                  dalteparin and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • darunavir

                  garlic decreases levels of darunavir by unknown mechanism. Use Caution/Monitor.

                • diclofenac

                  diclofenac and garlic both increase anticoagulation. Use Caution/Monitor.

                • diflunisal

                  diflunisal and garlic both increase anticoagulation. Use Caution/Monitor.

                • dong quai

                  dong quai and garlic both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • epoprostenol

                  epoprostenol and garlic both increase anticoagulation. Use Caution/Monitor.

                • etodolac

                  etodolac and garlic both increase anticoagulation. Use Caution/Monitor.

                • fennel

                  fennel and garlic both increase anticoagulation. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen and garlic both increase anticoagulation. Use Caution/Monitor.

                • feverfew

                  feverfew and garlic both increase anticoagulation. Use Caution/Monitor.

                • flurbiprofen

                  flurbiprofen and garlic both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • forskolin

                  forskolin and garlic both increase anticoagulation. Use Caution/Monitor.

                • fosamprenavir

                  garlic decreases levels of fosamprenavir by unknown mechanism. Use Caution/Monitor.

                • ginger

                  garlic and ginger both increase anticoagulation. Use Caution/Monitor.

                • ginkgo biloba

                  garlic and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

                • heparin

                  heparin and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  garlic and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen and garlic both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV and garlic both increase anticoagulation. Use Caution/Monitor.

                • indinavir

                  garlic decreases levels of indinavir by unknown mechanism. Use Caution/Monitor.

                • indomethacin

                  indomethacin and garlic both increase anticoagulation. Use Caution/Monitor.

                • ketoprofen

                  ketoprofen and garlic both increase anticoagulation. Use Caution/Monitor.

                • ketorolac

                  ketorolac and garlic both increase anticoagulation. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal and garlic both increase anticoagulation. Use Caution/Monitor.

                • lornoxicam

                  lornoxicam and garlic both increase anticoagulation. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate and garlic both increase anticoagulation. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid and garlic both increase anticoagulation. Use Caution/Monitor.

                • meloxicam

                  meloxicam and garlic both increase anticoagulation. Use Caution/Monitor.

                • mistletoe

                  garlic increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nabumetone

                  nabumetone and garlic both increase anticoagulation. Use Caution/Monitor.

                • naproxen

                  naproxen and garlic both increase anticoagulation. Use Caution/Monitor.

                • nelfinavir

                  garlic decreases levels of nelfinavir by unknown mechanism. Use Caution/Monitor.

                • nettle

                  garlic increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin and garlic both increase anticoagulation. Use Caution/Monitor.

                • panax ginseng

                  garlic and panax ginseng both increase anticoagulation. Use Caution/Monitor.

                • parecoxib

                  parecoxib and garlic both increase anticoagulation. Use Caution/Monitor.

                • pau d'arco

                  garlic and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • phytoestrogens

                  garlic and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • piroxicam

                  piroxicam and garlic both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • reishi

                  garlic and reishi both increase anticoagulation. Use Caution/Monitor.

                • reteplase

                  reteplase and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • ritonavir

                  garlic decreases levels of ritonavir by unknown mechanism. Use Caution/Monitor.

                • salicylates (non-asa)

                  salicylates (non-asa) and garlic both increase anticoagulation. Use Caution/Monitor.

                • salsalate

                  salsalate and garlic both increase anticoagulation. Use Caution/Monitor.

                • saquinavir

                  garlic decreases levels of saquinavir by unknown mechanism. Use Caution/Monitor.

                • Siberian ginseng

                  garlic and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sulfasalazine

                  sulfasalazine and garlic both increase anticoagulation. Use Caution/Monitor.

                • sulindac

                  sulindac and garlic both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                • tipranavir

                  garlic decreases levels of tipranavir by unknown mechanism. Use Caution/Monitor.

                • tolfenamic acid

                  tolfenamic acid and garlic both increase anticoagulation. Use Caution/Monitor.

                • tolmetin

                  tolmetin and garlic both increase anticoagulation. Use Caution/Monitor.

                • vitamin K1 (phytonadione)

                  garlic increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • vortioxetine

                  garlic, vortioxetine. Either increases effects of the other by anticoagulation. Use Caution/Monitor.

                • warfarin

                  warfarin and garlic both increase anticoagulation. Modify Therapy/Monitor Closely.

                Minor (4)

                • anamu

                  anamu and garlic both increase anticoagulation. Minor/Significance Unknown.

                • danshen

                  danshen and garlic both increase anticoagulation. Minor/Significance Unknown.

                • devil's claw

                  devil's claw and garlic both increase anticoagulation. Minor/Significance Unknown.

                • green tea

                  green tea, garlic. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

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                Adverse Effects

                Frequency Not Defined

                Anaphylaxis

                Angioedema

                Asthma

                Bleeding

                Conjunctivitis

                Contact dermatitis (topical use)

                Diarrhea

                Eczema (topical use)

                Flatulence

                GI irritation/burning

                GI upset

                Heartburn

                Nausea/vomiting

                Rhinitis

                Urticaria

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                Warnings

                Contraindications

                Bleeding disorders, surgery within 1-2 weeks

                Cautions

                Concurrent CYP 3A4 substrates, diabetes mellitus, GI infection, inflammatory bowel disease

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Decrease in cholesterol: 8-16 weeks

                Hypotensive effects: 1-6 month

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Active constituent: allicin

                Inhib. cholesterol biosynthesis

                Inhib. platelet aggregation, thromboxane synthesis, lysosomal enzyme release; decr vascular musc. tone

                Possible interference w/microbial structure, function

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.