lidocaine ophthalmic (Rx)

Brand and Other Names:Akten

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic gel

  • 3.5%

Ocular Surface Anesthesia

Indicated for ocular surface anesthesia during ophthalmologic procedures

Instill 2 gtts in affected eye(s)

May be reapplied to maintain anesthetic effect

Dosage Forms & Strengths

ophthalmic gel

  • 3.5%

Ocular Surface Anesthesia

Indicated for ocular surface anesthesia during ophthalmologic procedures

Instill 2 gtts in affected eye(s)

May be reapplied to maintain anesthetic effect

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Adverse Effects

Frequency Not Defined

Conjunctival hyperemia

Corneal epithelial changes

Headache

Burning upon instillation

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Warnings

Contraindications

None

Cautions

Not for injection; for ophthalmic use only

Caution with history of hypersensitivity to amide-type anesthetic

Prolonged use of a topical ocular anesthetic may produce permanent corneal opacification and ulceration with accompanying visual loss

Indicated for administration under direct supervision of healthcare provider; not intended for patient self-administration

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Pregnancy & Lactation

Pregnancy Category: B

Lactation: Secreted in human breast milk; unlikely systemic exposure with ophthalmic application (see Pharmacology)

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Elicits local anesthetic effect; stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses

Absorption

Minimal to no systemic absorption; depends on concentration, viscosity, and duration of exposure

Onset of action: 20 seconds to 1 minute

Duration of action: 5-30 minutes

Distribution

Protein bound: 60-80% (free base concentration of 1-4 mcg/mL)

Metabolism

Metabolized by the liver; metabolites are unchanged and excreted by the kidneys

Elimination

Half-life: 1.5-2 hr

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Images

No images available for this drug.
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Patient Handout

A Patient Handout is not currently available for this monograph.
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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.