Licorice (Herb/Suppl)

Brand and Other Names:alcacuz, Chinese licorice, more...gan cao, gan zao, glycyrrhiza glabra, lakritze, Lakritzenwurzel, orozuz, regliz, Russian licorice, Spanish licorice, sweet root, yashtimadhu, yo jyo hen shi ko
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Suggested Dosing

Root

1-4 g PO TID

Tea

1 cup PO TID; 1-4 g powdered root/150 ml water

Ulcer

760-1520 mg DGL PO, AC, must mix w/saliva; 8-16 weeks

Cough

0.5-1 g PO powdered root qD-TID

Other Information

Use no more than 4-6 weeks

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Suggested Uses

Adrenocortical insufficiency

Arthritis, bronchitis, dry cough, peptic ulcers, gastritis, infections (bacterial/viral), prostate cancer, sore throat, systemic lupus erythematosus, upper resp. inflammation

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Interactions

Interaction Checker

and Licorice

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Amenorrhea

            CHF

            Decreased libido

            Edema

            Erectile dysfunction

            Headache

            Hypertension

            Hypertensive encephalopathy

            Hypokalemia

            Hypokalemic myopathy

            Lethargy

            Lower extremity weakness

            Mineralocorticoid effects

            Myoglobinuria

            Pulmonary edema

            Quadriplegia

            Rhabdomyolysis

            Sodium

            Fluid retention

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            Warnings

            Contraindications

            Breast cancer, cholestatic liver disorders, cirrhosis, CHF, diabetes mellitus, endometriosis, hormone sensitive conditions, hypertonia, hypersensitivity to licorice, hypertension, hypokalemia, ovarian cancer, renal insufficiency (severe), uterine cancer, uterine fibroids

            Cautions

            Concurrent CYP 3A4 substrates or potassium-depleting agents

            Impaired liver function

            FDA consumer alert: Consuming >2 ounces/day for at least 2 weeks may cause hypokalemia and result in arrhythmia; adults aged 40 or older are at a higher risk (October 2011)

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            Pregnancy & Lactation

            Pregnancy Category: unsafe

            Lactation: avoid use

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Anti-inflammatory, expectorant; blocks PGE2 & PGF2-alpha metab.

            DGL less effective for upper resp. symptoms

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.