Alcaine, Ophthaine (proparacaine ophthalmic) dosing, indications, interactions, adverse effects, and more

Sections

Sections proparacaine ophthalmic
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

0.5%

Foreign Bodies & Suture Removal

1-2 gtt in eye(s) just prior to procedures

Deep Ophthalmic Anesthesia

1 gtt 5-10 min for 5-7 doses total

Dosage Forms & Strengths

ophthalmic solution

0.5%

Foreign Bodies & Suture Removal

1-2 gtt in eye(s) just prior to procedures

Deep Ophthalmic Anesthesia

1 gtt 5-10 min for 5-7 doses total

Frequency Not Defined

Contact dermatitis

Corneal damage

Blurred vision

CNS depression

Conjunctival congestion

Corneal opacification

Increased diaphoresis

Pain

Burning

Stinging

Redness

Keratitis

Tearing

Contraindications

Hypersensitivty to anesthetics (ester type)

Cautions

Use with caution and sparingly in patients with known allergies, cardiac disease, or hyperthyroidism

Any topical anesthetic can damage corneal epithelium; prolonged use not recommended

Pregnancy & Lactation

Pregnancy Category: C

Lactation: Not known if distributed in milk; use caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Reversibly blocks nerve conduction near the site of application

May limit sodium ion permeability through the lipid layer of the nerve cell membrane

Pharmacokinetics

Onset: 30 sec

Duration: 10-20 min

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

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View the formulary and any restrictions for each plan.
Manage and view all your plans together – even plans in different states.
Compare formulary status to other drugs in the same class.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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