Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 50mg/mL
tablet
- 250mg
- 500mg
Hypertension
Initial: 250 mg PO q8-12hr for 2 days, increase q2Days PRN
Maintenance: 250-1000 mg/day divided q6-12hr PO, usually no more than 3 g/day
IV (methyldopate): 250-1000 mg infusion over 30-60 minutes q6-8hr PRN; no more than 4 g/day
Hypertensive Crisis
20-40 mg/kg/day divided IV q6hr
No more than 65 mg/kg/day or 3 g/day (whichever is less)
Renal Impairment
Adjust dosage frequency with renal impairment
CrCl >50 mL/min: q8hr
CrCl 10-50 mL/min: q8-12hr
CrCl <10 mL/min: q12-24hr
Type 1 Diabetes Mellitus (Orphan)
Orphan designation for type 1 diabetes in DQ8 positive patients with residual beta cell function
Sponsor
- IM Therapeutics LLC; 11001 West 120th Avenue, Suite 400; Broomfield, Colorado 80021
Dosage Forms & Strengths
injectable solution
- 50mg/mL
tablet
- 250mg
- 500mg
Hypertension
Neonate: 2.5-5 mg/kg PO or IV q8hr
10 mg/kg/day divided q12hr PO, increase q2Days PRN
Hypertensive Crisis
20-40 mg/kg/day IV divided q6hr
No more than 65 mg/kg/day or 3 g/day (whichever is less)
Adverse CNS effects; may cause bradycardia and orthostatic hypotension; not recommended as routine treatment for hypertension (Beers criteria)
Not drug of choice in elderly because of CNS effects
Monitor renal function; renally excreted; decreased renal function more likely in elderly
Hypertension
Lower initial doses and more gradual adjustments recommended
125 mg qDay or q12hr; may increase by 125 mg-increments q2-3days PRN
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (30)
- aripiprazole
aripiprazole decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- benperidol
benperidol decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- chlorpromazine
chlorpromazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- clozapine
clozapine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- droperidol
droperidol decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- fluphenazine
fluphenazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- haloperidol
haloperidol decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- iloperidone
iloperidone decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- iobenguane I 131
methyldopa will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.
- lofexidine
lofexidine, methyldopa. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.
- loxapine
loxapine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- loxapine inhaled
loxapine inhaled decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- metoclopramide
metoclopramide decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Contraindicated.
metoclopramide decreases levels of methyldopa by pharmacodynamic antagonism. Contraindicated. - metoclopramide intranasal
methyldopa, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- olanzapine
olanzapine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- olopatadine intranasal
methyldopa and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- paliperidone
paliperidone decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- perphenazine
perphenazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- pexidartinib
methyldopa and pexidartinib both increase inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Pexidartinib can cause hepatotoxicity. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity.
- pimozide
pimozide decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- pretomanid
methyldopa, pretomanid. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Pretomanid regimen associated with hepatotoxicity. Avoid alcohol and hepatotoxic agents, including herbal supplements and drugs other than bedaquiline and linezolid.
- prochlorperazine
prochlorperazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- promethazine
promethazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- quetiapine
quetiapine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- risperidone
risperidone decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- thioridazine
thioridazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- thiothixene
thiothixene decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- tranylcypromine
tranylcypromine, methyldopa. Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine inhibits the hypotensive effects of methyldopa. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with methyldopa.
- trifluoperazine
trifluoperazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
- ziprasidone
ziprasidone decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.
Monitor Closely (56)
- apomorphine
apomorphine and methyldopa both increase dopaminergic effects. Use Caution/Monitor.
- benzphetamine
methyldopa increases effects of benzphetamine by unknown mechanism. Use Caution/Monitor.
- bretylium
methyldopa, bretylium. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Each drug may cause hypotension.
- cabergoline
cabergoline and methyldopa both increase dopaminergic effects. Use Caution/Monitor.
- carbonyl iron
carbonyl iron decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- clonidine
clonidine, methyldopa. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Sympatholytic action may worsen sinus node dysfunction and atrioventricular (AV) block.
- daridorexant
methyldopa and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- dexfenfluramine
methyldopa increases effects of dexfenfluramine by unknown mechanism. Use Caution/Monitor.
- dexmethylphenidate
methyldopa increases effects of dexmethylphenidate by unknown mechanism. Use Caution/Monitor.
- dextroamphetamine
methyldopa increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
- diethylpropion
methyldopa increases effects of diethylpropion by unknown mechanism. Use Caution/Monitor.
- difelikefalin
difelikefalin and methyldopa both increase sedation. Use Caution/Monitor.
- dobutamine
methyldopa increases effects of dobutamine by unknown mechanism. Use Caution/Monitor.
- dopamine
dopamine and methyldopa both increase dopaminergic effects. Use Caution/Monitor.
methyldopa increases effects of dopamine by unknown mechanism. Use Caution/Monitor. - entacapone
entacapone will increase the level or effect of methyldopa by decreasing metabolism. Use Caution/Monitor. Entacapone is a COMT inhibitor. Caution if coadministered with drugs metabolized by COMT. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure.
- ephedrine
methyldopa increases effects of ephedrine by unknown mechanism. Use Caution/Monitor.
- epinephrine
methyldopa increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
- fenfluramine
methyldopa increases effects of fenfluramine by unknown mechanism. Use Caution/Monitor.
- ferric maltol
ferric maltol decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- ferrous fumarate
ferrous fumarate decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- ferrous gluconate
ferrous gluconate decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- ferrous sulfate
ferrous sulfate decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- iron dextran complex
iron dextran complex decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- iron sucrose
iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- isoproterenol
methyldopa increases effects of isoproterenol by unknown mechanism. Use Caution/Monitor.
- levodopa
methyldopa, levodopa. pharmacodynamic synergism. Use Caution/Monitor. Risk of additive hypotensive effects, and risk of toxic CNS effects such as psychosis.
- lisdexamfetamine
methyldopa increases effects of lisdexamfetamine by unknown mechanism. Use Caution/Monitor.
- lisuride
lisuride and methyldopa both increase dopaminergic effects. Use Caution/Monitor.
- lurasidone
lurasidone increases effects of methyldopa by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of hypotension with concurrent use. Monitor blood pressure and adjust dose of antihypertensive agent as needed.
- methamphetamine
methyldopa increases effects of methamphetamine by unknown mechanism. Use Caution/Monitor.
- methylenedioxymethamphetamine
methyldopa increases effects of methylenedioxymethamphetamine by unknown mechanism. Use Caution/Monitor.
- methylphenidate
methyldopa increases effects of methylphenidate by unknown mechanism. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, methyldopa. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- midodrine
methyldopa increases effects of midodrine by unknown mechanism. Use Caution/Monitor.
- mipomersen
mipomersen, methyldopa. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.
- nadolol
nadolol, methyldopa. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Non selective beta blocker administration during withdrawal from methyldopa may result in rebound hypertension.
- norepinephrine
methyldopa increases effects of norepinephrine by unknown mechanism. Use Caution/Monitor.
- opicapone
opicapone will increase the level or effect of methyldopa by decreasing metabolism. Use Caution/Monitor. Opicapone is a COMT inhibitor. Caution if coadministered with drugs metabolized by COMT. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure.
- phendimetrazine
methyldopa increases effects of phendimetrazine by unknown mechanism. Use Caution/Monitor.
- phentermine
methyldopa increases effects of phentermine by unknown mechanism. Use Caution/Monitor.
- phenylephrine
methyldopa increases effects of phenylephrine by unknown mechanism. Use Caution/Monitor.
- phenylephrine PO
methyldopa increases effects of phenylephrine PO by unknown mechanism. Use Caution/Monitor.
- pindolol
pindolol, methyldopa. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Non selective beta blocker administration during withdrawal from methyldopa may result in rebound hypertension.
- polysaccharide iron
polysaccharide iron decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- pramipexole
methyldopa and pramipexole both increase dopaminergic effects. Use Caution/Monitor.
- propranolol
propranolol, methyldopa. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Non selective beta blocker administration during withdrawal from methyldopa may result in rebound hypertension.
- propylhexedrine
methyldopa increases effects of propylhexedrine by unknown mechanism. Use Caution/Monitor.
- pseudoephedrine
methyldopa increases effects of pseudoephedrine by unknown mechanism. Use Caution/Monitor.
- ropinirole
methyldopa and ropinirole both increase dopaminergic effects. Use Caution/Monitor.
- rose hips
rose hips decreases levels of methyldopa by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- serdexmethylphenidate/dexmethylphenidate
methyldopa increases effects of serdexmethylphenidate/dexmethylphenidate by unknown mechanism. Use Caution/Monitor.
- timolol
timolol, methyldopa. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Non selective beta blocker administration during withdrawal from methyldopa may result in rebound hypertension.
- tolcapone
tolcapone will increase the level or effect of methyldopa by decreasing metabolism. Use Caution/Monitor. Tolcapone is a COMT inhibitor. Caution if coadministered with drugs metabolized by COMT. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure.
- valoctocogene roxaparvovec
methyldopa and valoctocogene roxaparvovec both increase Other (see comment). Use Caution/Monitor. Medications that may cause hepatotoxicity when combined with valoctogene roxaparvovec may potentiate the risk of elevated liver enzymes. Closely monitor these medications and consider alternative medications in case of potential drug interactions.
- xylometazoline
methyldopa increases effects of xylometazoline by unknown mechanism. Use Caution/Monitor.
- yohimbine
methyldopa increases effects of yohimbine by unknown mechanism. Use Caution/Monitor.
Minor (1)
- lithium
methyldopa increases toxicity of lithium by unknown mechanism. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Angina
Bradycardia
Orthostatic hypotension
Depression
Dizziness
Lethargy
Sedation
Rash
Gynecomastia
Impotence
Dry mouth
Nausea
Vomiting
Hemolytic anemia
Thrombocytopenia
Liver toxicity
Arthralgia
Autoimmune disease
Lupus-like syndrome
Warnings
Contraindications
Active liver disease, liver disorders associated with previous methyldopa treatment
Hypersensitivity to methyldopa or other ingredients (eg, sulfites)
Pheochromocytoma
Concomitant MAOIs
Cautions
CHF, dialysis patients (increased risk of hypertension following procedure), edema, hemolytic anemia, hypotension, severe bilateral CVD, history of liver disease
Avoid abrupt withdrawal
Risk of decreased libido and impotence in men
May impair ability to perform hazardous tasks
Tolerance develops on prolonged treatment, especially if no concurrent diuretic (methyldopa causes Na and water retention)
Interferes with some lab tests
IM/SC NOT recommended due to erratic absorption
Pregnancy & Lactation
Pregnancy Category: B
Lactation: distributed in breast milk but not in clinically significant amounts; compatible w/ breastfeeding
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Methyldopa may lower blood pressure by stimulating central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity.
Pharmacokinetics
Onset: PO 3-6 hr; IV 4-6 hr
Duration: PO 12-24 hr; IV 10-16 hr
Absorption: 50%
Protein Bound: Minimal
Vd: 0.6 L/kg
Metabolism: Liver
Metabolite: Methyldopa-o-sulfate (may be active), 3-methoxy-methyldopa (inactive)
Excretion: Urine (70%), feces (30-50%)
Dialyzable: Yes (HD; removes 60%; PD removes lesser amount)
Administration
IV Incompatibilities
Additive: ampho B, methohexital
IV Compatibilities
Solution: D5W, NS, Ringer's, D5/NS
Additive: aminophylline, ascorbic acid, chloramphenicol, diphenhydramine, heparin, MgSO4, netilmicin, KCl, promazine, NaHCO3, succinylcholine, verapamil, vitamin B/C
Y-site: esmolol, heparin, meperidine, morphine SO4, theophylline
IV Preparation
Dilute required dose in 100 mL D5W
IV Administration
Slow infusion over 30-60 min
Oral Administration
May increase dose/give higher amount HS to avoid adverse events during waking hours
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| methyldopa oral - | 500 mg tablet |  | |
| methyldopa oral - | 250 mg tablet |  | |
| methyldopa oral - | 250 mg tablet |  | |
| methyldopa oral - | 500 mg tablet |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
methyldopa oral
METHYLDOPA - ORAL
(METH-il-DOE-pa)
COMMON BRAND NAME(S): Aldomet
USES: This medication is used alone or with other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Methyldopa works by relaxing blood vessels so blood can flow more easily.
HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually 2 to 4 times daily. Start this medication or any new dose increase in the evening to decrease the risk of side effects. Also, if the doses of this medication are not equal, take the larger dose at bedtime.The dosage is based on your medical condition and response to treatment.Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.When used for a long time, this medication may not work as well and may require different dosing or an additional medication. Talk with your doctor if this medication stops working well (such as your blood pressure readings remain high or increase).
SIDE EFFECTS: Dizziness, lightheadedness, drowsiness, headache, stuffy nose, and weakness may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, muscle spasms/uncontrolled muscle movements, missed/stopped periods, decreased sexual desire/ability, increased breast size (in men), mental/mood changes (such as depression), symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).Methyldopa has rarely caused very serious (rarely fatal) liver disease or low red blood cell count (anemia). Tell your doctor right away if you develop any symptoms of liver disease or anemia, including: nausea/vomiting that doesn't stop, unusual tiredness, fast heartbeat, unexplained fever, dark urine, severe stomach/abdominal pain, yellowing eyes/skin.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking methyldopa, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (such as hepatitis, cirrhosis), low red blood cell count (anemia), heart failure, pheochromocytoma, a certain genetic condition (glucose-6-phosphate dehydrogenase deficiency).This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this medication, especially dizziness (more likely when standing up), fainting, or depression. Dizziness and fainting can increase the risk of falling.Tell your doctor if you are pregnant before using this medication.This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: iron products (such as ferrous sulfate, ferrous gluconate), lithium.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.Some products have ingredients that could raise your blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).This medication may interfere with certain lab tests (such as urine catecholamine test), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness/dizziness.
NOTES: Do not share this medication with others.Lab and/or medical tests (such as hematocrit/hemoglobin, complete blood count, Coombs test, liver function) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure at home, and share the results with your doctor.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
