Dosing & Uses
Dosage Forms & Strengths
diphenhydramine/allantoin
topical cream
- 2%/0.5%
Itching
Temporarily relieves pain and itching associated with insect bites, minor skin irritations, sunburn, rashes, or minor burns, cuts, or scrapes
Apply to affected area PRN; not to exceed 3-4 applications/day
Administration
Avoid eyes
Dosage Forms & Strengths
diphenhydramine/allantoin
topical cream
- 2%/0.5%
Itching
Temporarily relieves pain and itching associated with insect bites, minor skin irritations, sunburn, rashes, or minor burns, cuts, or scrapes
<2 years: Safety and efficacy not established
≥2 years: Apply to affected area PRN; not to exceed 3-4 applications/day
Administration
Avoid eyes
Warnings
Contraindications
Hypersensitivity
Cautions
Do not use more than directed
Do not use large areas of the body
Do not use with other diphenhydramine products, including oral products
Do not use on deep or puncture wounds, animal bites, or serious burns
Do not use on serious sunburn or broken, blistered or oozing skin
Advise patient to contact physician if condition worsens or symptoms persist beyond 7 days
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Unknown whether distributed in breast milk
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Diphenhydramine: Histamine H1-receptor antagonist; elicits topical anesthetic effects
Allantoin: Skin protectant
