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      News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point
      Drugs & Diseases

      brimonidine (Rx, OTC)

      Brand and Other Names:Alphagan P, Qoliana, more...Lumify
      • Print

      Dosing & Uses

      AdultPediatric

      Dosage Forms & Strengths

      ophthalmic solution (Rx)

      • 0.1% (Alphagan P)
      • 0.15% (Alphagan P, Qoliana, generic)

      ophthalmic solution (OTC)

      • 0.025% (Lumify)

      Elevated Intraocular Pressure

      Indicated to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

      Alphagan P, Qoliana: 1 gtt in affected eye(s) q8hr

      Ocular Redness

      Indicated to relieve ocular redness caused by minor eye irritations

      Lumify: Instill 1 gtt in affected eye(s) q6-8hr

      Optic Neuropathy (Orphan)

      Treatment of anterior ischemic optic neuropathy

      Orphan indication sponsor

      • Allergan, Inc; 2525 Dupont Drive, P.O. Box 19534; Irvine, CA 92713

      Graft vs Host Disease (Orphan)

      Orphan designation for ocular GVHD

      Sponsor

      • Ocugen, Inc; 5 Great Valley Parkway, Suite 160; Malvern, Pennsylvania 19355

      Dosage Forms & Strengths

      ophthalmic solution (Rx)

      • 0.1% (Alphagan P)
      • 0.15% (Alphagan P, Qoliana, generic)

      ophthalmic solution (OTC)

      • 0.025% (Lumify)

      Elevated Intraocular Pressure

      Indicated to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

      <2 years: Contraindicated

      ≥2 years: Alphagan P, Qoliana: 1 gtt in affected eye(s) q8hr

      Ocular Redness

      Indicated to relieve ocular redness caused by minor eye irritations in adults and children aged ≥5 yr

      <5 years (Lumify): Safety and efficacy not established

      ≥5 years (Lumify): Instill 1 gtt in affected eye(s) q6-8hr

      Next:

      Interactions

      Interaction Checker

      and brimonidine

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

              Minor

                All Interactions Sort By:
                 activity indicator 

                Contraindicated (9)

                • isocarboxazid

                  isocarboxazid, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

                • linezolid

                  linezolid, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

                • phenelzine

                  phenelzine, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

                • procarbazine

                  procarbazine, brimonidine. Mechanism: unknown. Contraindicated.

                • rasagiline

                  rasagiline, brimonidine. Mechanism: unknown. Contraindicated. Brimonidine should not be used in patients receiving MAO inhibitors.

                • selegiline

                  selegiline, brimonidine. Mechanism: unknown. Contraindicated. Coadministration is contraindicated.

                • selegiline transdermal

                  selegiline transdermal, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

                • thalidomide

                  brimonidine and thalidomide both increase sedation. Contraindicated.

                • tranylcypromine

                  tranylcypromine, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

                Serious - Use Alternative (19)

                • alfentanil

                  brimonidine and alfentanil both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • buprenorphine

                  brimonidine and buprenorphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • buprenorphine buccal

                  brimonidine and buprenorphine buccal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • buprenorphine subdermal implant

                  brimonidine and buprenorphine subdermal implant both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • buprenorphine transdermal

                  brimonidine and buprenorphine transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • buprenorphine, long-acting injection

                  brimonidine and buprenorphine, long-acting injection both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • codeine

                  brimonidine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • fentanyl

                  brimonidine and fentanyl both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • fentanyl intranasal

                  brimonidine and fentanyl intranasal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • fentanyl iontophoretic transdermal system

                  brimonidine and fentanyl iontophoretic transdermal system both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • fentanyl transdermal

                  brimonidine and fentanyl transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • fentanyl transmucosal

                  brimonidine and fentanyl transmucosal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • hydrocodone

                  brimonidine and hydrocodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • hydromorphone

                  brimonidine and hydromorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • methadone

                  brimonidine and methadone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • morphine

                  brimonidine and morphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • oxycodone

                  brimonidine and oxycodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • oxymorphone

                  brimonidine and oxymorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                • remifentanil

                  brimonidine and remifentanil both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

                Monitor Closely (172)

                • acetaminophen/phenyltoloxamine

                  brimonidine and acetaminophen/phenyltoloxamine both increase sedation. Use Caution/Monitor.

                • acrivastine

                  acrivastine and brimonidine both increase sedation. Use Caution/Monitor.

                • alprazolam

                  brimonidine and alprazolam both increase sedation. Use Caution/Monitor.

                • amifostine

                  amifostine, brimonidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.

                • amisulpride

                  amisulpride and brimonidine both increase sedation. Use Caution/Monitor.

                • amitriptyline

                  brimonidine and amitriptyline both increase sedation. Use Caution/Monitor.

                • amobarbital

                  brimonidine and amobarbital both increase sedation. Use Caution/Monitor.

                • amoxapine

                  brimonidine and amoxapine both increase sedation. Use Caution/Monitor.

                • aripiprazole

                  brimonidine and aripiprazole both increase sedation. Use Caution/Monitor.

                • asenapine

                  asenapine and brimonidine both increase sedation. Use Caution/Monitor.

                • asenapine transdermal

                  asenapine transdermal and brimonidine both increase sedation. Use Caution/Monitor.

                • avapritinib

                  avapritinib and brimonidine both increase sedation. Use Caution/Monitor.

                  brimonidine and avapritinib both increase sedation. Use Caution/Monitor.

                • baclofen

                  brimonidine and baclofen both increase sedation. Use Caution/Monitor.

                • benzhydrocodone/acetaminophen

                  benzhydrocodone/acetaminophen and brimonidine both increase sedation. Use Caution/Monitor.

                • brexanolone

                  brimonidine and brexanolone both increase sedation. Use Caution/Monitor.

                • brexpiprazole

                  brexpiprazole and brimonidine both increase sedation. Use Caution/Monitor.

                  brimonidine and brexpiprazole both increase sedation. Use Caution/Monitor.

                • brivaracetam

                  brimonidine and brivaracetam both increase sedation. Use Caution/Monitor.

                  brivaracetam and brimonidine both increase sedation. Use Caution/Monitor.

                • brompheniramine

                  brimonidine and brompheniramine both increase sedation. Use Caution/Monitor.

                • buprenorphine subdermal implant

                  buprenorphine subdermal implant and brimonidine both increase sedation. Use Caution/Monitor.

                • butabarbital

                  brimonidine and butabarbital both increase sedation. Use Caution/Monitor.

                • butalbital

                  brimonidine and butalbital both increase sedation. Use Caution/Monitor.

                • butorphanol

                  brimonidine and butorphanol both increase sedation. Use Caution/Monitor.

                • candesartan

                  brimonidine increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor.

                • carbinoxamine

                  brimonidine and carbinoxamine both increase sedation. Use Caution/Monitor.

                • cariprazine

                  brimonidine and cariprazine both increase sedation. Use Caution/Monitor.

                • carisoprodol

                  brimonidine and carisoprodol both increase sedation. Use Caution/Monitor.

                • cenobamate

                  brimonidine and cenobamate both increase sedation. Use Caution/Monitor.

                • cetirizine

                  brimonidine and cetirizine both increase sedation. Use Caution/Monitor.

                • chlordiazepoxide

                  brimonidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

                • chlorpheniramine

                  brimonidine and chlorpheniramine both increase sedation. Use Caution/Monitor.

                • chlorpromazine

                  brimonidine and chlorpromazine both increase sedation. Use Caution/Monitor.

                • chlorzoxazone

                  brimonidine and chlorzoxazone both increase sedation. Use Caution/Monitor.

                • clemastine

                  brimonidine and clemastine both increase sedation. Use Caution/Monitor.

                • clobazam

                  brimonidine and clobazam both increase sedation. Use Caution/Monitor.

                • clomipramine

                  brimonidine and clomipramine both increase sedation. Use Caution/Monitor.

                • clonazepam

                  brimonidine and clonazepam both increase sedation. Use Caution/Monitor.

                • clonidine

                  brimonidine and clonidine both increase sedation. Use Caution/Monitor.

                • clorazepate

                  brimonidine and clorazepate both increase sedation. Use Caution/Monitor.

                • clozapine

                  brimonidine and clozapine both increase sedation. Use Caution/Monitor.

                • cyclobenzaprine

                  brimonidine and cyclobenzaprine both increase sedation. Use Caution/Monitor.

                • cyproheptadine

                  brimonidine and cyproheptadine both increase sedation. Use Caution/Monitor.

                • dantrolene

                  brimonidine and dantrolene both increase sedation. Use Caution/Monitor.

                • daridorexant

                  brimonidine and daridorexant both increase sedation. Use Caution/Monitor.

                • desflurane

                  brimonidine and desflurane both increase sedation. Use Caution/Monitor.

                • desipramine

                  brimonidine and desipramine both increase sedation. Use Caution/Monitor.

                • deutetrabenazine

                  brimonidine and deutetrabenazine both increase sedation. Use Caution/Monitor.

                • dexbrompheniramine

                  brimonidine and dexbrompheniramine both increase sedation. Use Caution/Monitor.

                • dexchlorpheniramine

                  brimonidine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                • diazepam

                  brimonidine and diazepam both increase sedation. Use Caution/Monitor.

                • difenoxin hcl

                  brimonidine and difenoxin hcl both increase sedation. Use Caution/Monitor.

                • digoxin

                  brimonidine increases effects of digoxin by pharmacodynamic synergism. Use Caution/Monitor.

                • dimenhydrinate

                  brimonidine and dimenhydrinate both increase sedation. Use Caution/Monitor.

                • diphenhydramine

                  brimonidine and diphenhydramine both increase sedation. Use Caution/Monitor.

                • diphenoxylate hcl

                  brimonidine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

                • doxepin

                  brimonidine and doxepin both increase sedation. Use Caution/Monitor.

                • doxylamine

                  brimonidine and doxylamine both increase sedation. Use Caution/Monitor.

                • droperidol

                  brimonidine and droperidol both increase sedation. Use Caution/Monitor.

                • efavirenz

                  brimonidine and efavirenz both increase sedation. Use Caution/Monitor.

                • entacapone

                  brimonidine and entacapone both increase sedation. Use Caution/Monitor.

                • eprosartan

                  brimonidine increases effects of eprosartan by pharmacodynamic synergism. Use Caution/Monitor.

                • esketamine intranasal

                  esketamine intranasal, brimonidine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

                • estazolam

                  brimonidine and estazolam both increase sedation. Use Caution/Monitor.

                • eszopiclone

                  brimonidine and eszopiclone both increase sedation. Use Caution/Monitor.

                • ethanol

                  brimonidine and ethanol both increase sedation. Use Caution/Monitor.

                • ethosuximide

                  brimonidine and ethosuximide both increase sedation. Use Caution/Monitor.

                • ethotoin

                  brimonidine and ethotoin both increase sedation. Use Caution/Monitor.

                • felbamate

                  brimonidine and felbamate both increase sedation. Use Caution/Monitor.

                • fenfluramine

                  brimonidine and fenfluramine both increase sedation. Use Caution/Monitor.

                • fexofenadine

                  brimonidine and fexofenadine both increase sedation. Use Caution/Monitor.

                • flibanserin

                  brimonidine and flibanserin both increase sedation. Use Caution/Monitor.

                • fluphenazine

                  brimonidine and fluphenazine both increase sedation. Use Caution/Monitor.

                • flurazepam

                  brimonidine and flurazepam both increase sedation. Use Caution/Monitor.

                • gabapentin

                  brimonidine and gabapentin both increase sedation. Use Caution/Monitor.

                • ganaxolone

                  brimonidine and ganaxolone both increase sedation. Use Caution/Monitor.

                • guanfacine

                  brimonidine and guanfacine both increase sedation. Use Caution/Monitor.

                • haloperidol

                  brimonidine and haloperidol both increase sedation. Use Caution/Monitor.

                • hydroxyzine

                  brimonidine and hydroxyzine both increase sedation. Use Caution/Monitor.

                • iloperidone

                  brimonidine and iloperidone both increase sedation. Use Caution/Monitor.

                • imipramine

                  brimonidine and imipramine both increase sedation. Use Caution/Monitor.

                • irbesartan

                  brimonidine increases effects of irbesartan by pharmacodynamic synergism. Use Caution/Monitor.

                • isoflurane

                  brimonidine and isoflurane both increase sedation. Use Caution/Monitor.

                • ketamine

                  brimonidine and ketamine both increase sedation. Use Caution/Monitor.

                • ketotifen, drug-eluting contact lens

                  brimonidine and ketotifen, drug-eluting contact lens both increase sedation. Use Caution/Monitor.

                • lamotrigine

                  brimonidine and lamotrigine both increase sedation. Use Caution/Monitor.

                • lasmiditan

                  lasmiditan, brimonidine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

                • lemborexant

                  brimonidine and lemborexant both increase sedation. Use Caution/Monitor.

                • levetiracetam

                  brimonidine and levetiracetam both increase sedation. Use Caution/Monitor.

                • levocetirizine

                  brimonidine and levocetirizine both increase sedation. Use Caution/Monitor.

                • levorphanol

                  brimonidine and levorphanol both increase sedation. Use Caution/Monitor.

                • loratadine

                  brimonidine and loratadine both increase sedation. Use Caution/Monitor.

                • lorazepam

                  brimonidine and lorazepam both increase sedation. Use Caution/Monitor.

                • losartan

                  brimonidine increases effects of losartan by pharmacodynamic synergism. Use Caution/Monitor.

                • loxapine

                  brimonidine and loxapine both increase sedation. Use Caution/Monitor.

                • lumateperone

                  brimonidine and lumateperone both increase sedation. Use Caution/Monitor.

                • lurasidone

                  lurasidone, brimonidine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased sedation.

                  brimonidine and lurasidone both increase sedation. Use Caution/Monitor.

                • maprotiline

                  brimonidine and maprotiline both increase sedation. Use Caution/Monitor.

                • meclizine

                  brimonidine and meclizine both increase sedation. Use Caution/Monitor.

                • meperidine

                  brimonidine and meperidine both increase sedation. Use Caution/Monitor.

                • meprobamate

                  brimonidine and meprobamate both increase sedation. Use Caution/Monitor.

                • metaxalone

                  brimonidine and metaxalone both increase sedation. Use Caution/Monitor.

                • methocarbamol

                  brimonidine and methocarbamol both increase sedation. Use Caution/Monitor.

                • methohexital

                  brimonidine and methohexital both increase sedation. Use Caution/Monitor.

                • methsuximide

                  brimonidine and methsuximide both increase sedation. Use Caution/Monitor.

                • midazolam

                  brimonidine and midazolam both increase sedation. Use Caution/Monitor.

                • mirtazapine

                  brimonidine and mirtazapine both increase sedation. Use Caution/Monitor.

                • molindone

                  brimonidine and molindone both increase sedation. Use Caution/Monitor.

                • nalbuphine

                  brimonidine and nalbuphine both increase sedation. Use Caution/Monitor.

                • nitroglycerin rectal

                  nitroglycerin rectal, brimonidine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Observe for possible additive hypotensive effects during concomitant use. .

                • nitrous oxide

                  brimonidine and nitrous oxide both increase sedation. Use Caution/Monitor.

                • nortriptyline

                  brimonidine and nortriptyline both increase sedation. Use Caution/Monitor.

                • olanzapine

                  brimonidine and olanzapine both increase sedation. Use Caution/Monitor.

                • oliceridine

                  brimonidine and oliceridine both increase sedation. Use Caution/Monitor.

                • olmesartan

                  brimonidine increases effects of olmesartan by pharmacodynamic synergism. Use Caution/Monitor.

                • olopatadine intranasal

                  brimonidine and olopatadine intranasal both increase sedation. Use Caution/Monitor.

                • opicapone

                  brimonidine and opicapone both increase sedation. Use Caution/Monitor.

                • opium tincture

                  brimonidine and opium tincture both increase sedation. Use Caution/Monitor.

                • orphenadrine

                  brimonidine and orphenadrine both increase sedation. Use Caution/Monitor.

                • oxazepam

                  brimonidine and oxazepam both increase sedation. Use Caution/Monitor.

                • paliperidone

                  brimonidine and paliperidone both increase sedation. Use Caution/Monitor.

                • pentazocine

                  brimonidine and pentazocine both increase sedation. Use Caution/Monitor.

                • pentobarbital

                  brimonidine and pentobarbital both increase sedation. Use Caution/Monitor.

                • perampanel

                  brimonidine and perampanel both increase sedation. Use Caution/Monitor.

                • perphenazine

                  brimonidine and perphenazine both increase sedation. Use Caution/Monitor.

                • pheniramine

                  brimonidine and pheniramine both increase sedation. Use Caution/Monitor.

                • phenobarbital

                  brimonidine and phenobarbital both increase sedation. Use Caution/Monitor.

                • pimozide

                  brimonidine and pimozide both increase sedation. Use Caution/Monitor.

                • pomalidomide

                  brimonidine and pomalidomide both increase sedation. Use Caution/Monitor.

                • pregabalin

                  brimonidine and pregabalin both increase sedation. Use Caution/Monitor.

                • primidone

                  brimonidine and primidone both increase sedation. Use Caution/Monitor.

                • prochlorperazine

                  brimonidine and prochlorperazine both increase sedation. Use Caution/Monitor.

                • promethazine

                  brimonidine and promethazine both increase sedation. Use Caution/Monitor.

                • propofol

                  brimonidine and propofol both increase sedation. Use Caution/Monitor.

                • protriptyline

                  brimonidine and protriptyline both increase sedation. Use Caution/Monitor.

                • pyrilamine

                  brimonidine and pyrilamine both increase sedation. Use Caution/Monitor.

                • quazepam

                  brimonidine and quazepam both increase sedation. Use Caution/Monitor.

                • quetiapine

                  brimonidine and quetiapine both increase sedation. Use Caution/Monitor.

                • ramelteon

                  brimonidine and ramelteon both increase sedation. Use Caution/Monitor.

                • remimazolam

                  brimonidine and remimazolam both increase sedation. Use Caution/Monitor.

                • reserpine

                  brimonidine and reserpine both increase sedation. Use Caution/Monitor.

                • risperidone

                  brimonidine and risperidone both increase sedation. Use Caution/Monitor.

                • sacubitril/valsartan

                  brimonidine increases effects of sacubitril/valsartan by pharmacodynamic synergism. Use Caution/Monitor.

                • scopolamine

                  brimonidine and scopolamine both increase sedation. Use Caution/Monitor.

                • sevoflurane

                  brimonidine and sevoflurane both increase sedation. Use Caution/Monitor.

                • sodium oxybate

                  brimonidine and sodium oxybate both increase sedation. Use Caution/Monitor.

                • stiripentol

                  stiripentol, brimonidine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

                • sufentanil

                  brimonidine and sufentanil both increase sedation. Use Caution/Monitor.

                • sufentanil SL

                  brimonidine and sufentanil SL both increase sedation. Use Caution/Monitor.

                • suvorexant

                  brimonidine and suvorexant both increase sedation. Use Caution/Monitor.

                • tapentadol

                  brimonidine and tapentadol both increase sedation. Use Caution/Monitor.

                • tasimelteon

                  brimonidine and tasimelteon both increase sedation. Use Caution/Monitor.

                • telmisartan

                  brimonidine increases effects of telmisartan by pharmacodynamic synergism. Use Caution/Monitor.

                • temazepam

                  brimonidine and temazepam both increase sedation. Use Caution/Monitor.

                • tetrabenazine

                  brimonidine and tetrabenazine both increase sedation. Use Caution/Monitor.

                • thioridazine

                  brimonidine and thioridazine both increase sedation. Use Caution/Monitor.

                • thiothixene

                  brimonidine and thiothixene both increase sedation. Use Caution/Monitor.

                • tiagabine

                  brimonidine and tiagabine both increase sedation. Use Caution/Monitor.

                • tizanidine

                  brimonidine and tizanidine both increase sedation. Use Caution/Monitor.

                • tolcapone

                  brimonidine and tolcapone both increase sedation. Use Caution/Monitor.

                • topiramate

                  brimonidine and topiramate both increase sedation. Use Caution/Monitor.

                • tramadol

                  brimonidine and tramadol both increase sedation. Use Caution/Monitor.

                • trazodone

                  brimonidine and trazodone both increase sedation. Use Caution/Monitor.

                • triazolam

                  brimonidine and triazolam both increase sedation. Use Caution/Monitor.

                • trifluoperazine

                  brimonidine and trifluoperazine both increase sedation. Use Caution/Monitor.

                • triprolidine

                  brimonidine and triprolidine both increase sedation. Use Caution/Monitor.

                • valproic acid

                  brimonidine and valproic acid both increase sedation. Use Caution/Monitor.

                • valsartan

                  brimonidine increases effects of valsartan by pharmacodynamic synergism. Use Caution/Monitor.

                • vigabatrin

                  brimonidine and vigabatrin both increase sedation. Use Caution/Monitor.

                • zaleplon

                  brimonidine and zaleplon both increase sedation. Use Caution/Monitor.

                • ziconotide

                  brimonidine and ziconotide both increase sedation. Use Caution/Monitor.

                • ziprasidone

                  brimonidine and ziprasidone both increase sedation. Use Caution/Monitor.

                • zolpidem

                  brimonidine and zolpidem both increase sedation. Use Caution/Monitor.

                • zonisamide

                  brimonidine and zonisamide both increase sedation. Use Caution/Monitor.

                Minor (177)

                • acebutolol

                  brimonidine increases effects of acebutolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • alfentanil

                  brimonidine increases effects of alfentanil by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • alfuzosin

                  brimonidine increases effects of alfuzosin by pharmacodynamic synergism. Minor/Significance Unknown.

                • alprazolam

                  brimonidine increases effects of alprazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • amiloride

                  brimonidine increases effects of amiloride by pharmacodynamic synergism. Minor/Significance Unknown.

                • amitriptyline

                  amitriptyline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • amlodipine

                  brimonidine increases effects of amlodipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • amobarbital

                  brimonidine increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • amoxapine

                  amoxapine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • aripiprazole

                  brimonidine increases effects of aripiprazole by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • asenapine

                  brimonidine increases effects of asenapine by pharmacodynamic synergism. Minor/Significance Unknown.

                • atenolol

                  brimonidine increases effects of atenolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • azelastine

                  brimonidine increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • belladonna and opium

                  brimonidine increases effects of belladonna and opium by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • benazepril

                  brimonidine increases effects of benazepril by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.

                • bendroflumethiazide

                  brimonidine increases effects of bendroflumethiazide by pharmacodynamic synergism. Minor/Significance Unknown.

                • benperidol

                  brimonidine increases effects of benperidol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • betaxolol

                  brimonidine increases effects of betaxolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • bisoprolol

                  brimonidine increases effects of bisoprolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • bosentan

                  brimonidine increases effects of bosentan by pharmacodynamic synergism. Minor/Significance Unknown.

                • brompheniramine

                  brimonidine increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • bumetanide

                  brimonidine increases effects of bumetanide by pharmacodynamic synergism. Minor/Significance Unknown.

                • buprenorphine

                  brimonidine increases effects of buprenorphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • buprenorphine buccal

                  brimonidine increases effects of buprenorphine buccal by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • butabarbital

                  brimonidine increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • butalbital

                  brimonidine increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • butorphanol

                  brimonidine increases effects of butorphanol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • captopril

                  brimonidine increases effects of captopril by pharmacodynamic synergism. Minor/Significance Unknown. Both drugs lower blood pressure. Monitor blood pressure.

                • carbinoxamine

                  brimonidine increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • carvedilol

                  brimonidine increases effects of carvedilol by pharmacodynamic synergism. Minor/Significance Unknown.

                • celiprolol

                  brimonidine increases effects of celiprolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • chloral hydrate

                  brimonidine increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • chlordiazepoxide

                  brimonidine increases effects of chlordiazepoxide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • chlorothiazide

                  brimonidine increases effects of chlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown.

                • chlorpheniramine

                  brimonidine increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • chlorpromazine

                  brimonidine increases effects of chlorpromazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • chlorthalidone

                  brimonidine increases effects of chlorthalidone by pharmacodynamic synergism. Minor/Significance Unknown.

                • cinnarizine

                  brimonidine increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • clemastine

                  brimonidine increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • clevidipine

                  brimonidine increases effects of clevidipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • clomipramine

                  clomipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • clonazepam

                  brimonidine increases effects of clonazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • clonidine

                  brimonidine increases effects of clonidine by pharmacodynamic synergism. Minor/Significance Unknown.

                • clorazepate

                  brimonidine increases effects of clorazepate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • clozapine

                  brimonidine increases effects of clozapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • codeine

                  brimonidine increases effects of codeine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • cyclizine

                  brimonidine increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • cyclopenthiazide

                  brimonidine increases effects of cyclopenthiazide by pharmacodynamic synergism. Minor/Significance Unknown.

                • cyproheptadine

                  brimonidine increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • desipramine

                  desipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • dexchlorpheniramine

                  brimonidine increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • dexmedetomidine

                  brimonidine increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • dextromoramide

                  brimonidine increases effects of dextromoramide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • diamorphine

                  brimonidine increases effects of diamorphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • diazepam

                  brimonidine increases effects of diazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • difenoxin hcl

                  brimonidine increases effects of difenoxin hcl by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • diltiazem

                  brimonidine increases effects of diltiazem by pharmacodynamic synergism. Minor/Significance Unknown.

                • dimenhydrinate

                  brimonidine increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • diphenhydramine

                  brimonidine increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • diphenoxylate hcl

                  brimonidine increases effects of diphenoxylate hcl by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • dipipanone

                  brimonidine increases effects of dipipanone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • doxazosin

                  brimonidine increases effects of doxazosin by pharmacodynamic synergism. Minor/Significance Unknown.

                • doxepin

                  doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • doxylamine

                  brimonidine increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • droperidol

                  brimonidine increases effects of droperidol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • drospirenone

                  brimonidine increases effects of drospirenone by pharmacodynamic synergism. Minor/Significance Unknown.

                • enalapril

                  brimonidine increases effects of enalapril by pharmacodynamic synergism. Minor/Significance Unknown.

                • eplerenone

                  brimonidine increases effects of eplerenone by pharmacodynamic synergism. Minor/Significance Unknown.

                • epoprostenol

                  brimonidine increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.

                • esmolol

                  brimonidine increases effects of esmolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • estazolam

                  brimonidine increases effects of estazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • ethacrynic acid

                  brimonidine increases effects of ethacrynic acid by pharmacodynamic synergism. Minor/Significance Unknown.

                • ethanol

                  brimonidine increases effects of ethanol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • etomidate

                  brimonidine increases effects of etomidate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • felodipine

                  brimonidine increases effects of felodipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • fenoldopam

                  brimonidine increases effects of fenoldopam by pharmacodynamic synergism. Minor/Significance Unknown.

                • fluphenazine

                  brimonidine increases effects of fluphenazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • flurazepam

                  brimonidine increases effects of flurazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • fosinopril

                  brimonidine increases effects of fosinopril by pharmacodynamic synergism. Minor/Significance Unknown.

                • furosemide

                  brimonidine increases effects of furosemide by pharmacodynamic synergism. Minor/Significance Unknown.

                • guanfacine

                  brimonidine increases effects of guanfacine by pharmacodynamic synergism. Minor/Significance Unknown.

                • haloperidol

                  brimonidine increases effects of haloperidol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • hydralazine

                  brimonidine increases effects of hydralazine by pharmacodynamic synergism. Minor/Significance Unknown.

                • hydrochlorothiazide

                  brimonidine increases effects of hydrochlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown.

                • hydromorphone

                  brimonidine increases effects of hydromorphone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • hydroxyzine

                  brimonidine increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • iloperidone

                  brimonidine increases effects of iloperidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • iloprost

                  brimonidine increases effects of iloprost by pharmacodynamic synergism. Minor/Significance Unknown.

                • imidapril

                  brimonidine increases effects of imidapril by pharmacodynamic synergism. Minor/Significance Unknown.

                • imipramine

                  imipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • indapamide

                  brimonidine increases effects of indapamide by pharmacodynamic synergism. Minor/Significance Unknown.

                • isradipine

                  brimonidine increases effects of isradipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • ketanserin

                  brimonidine increases effects of ketanserin by pharmacodynamic synergism. Minor/Significance Unknown.

                • labetalol

                  brimonidine increases effects of labetalol by pharmacodynamic synergism. Minor/Significance Unknown.

                • levorphanol

                  brimonidine increases effects of levorphanol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • lisinopril

                  brimonidine increases effects of lisinopril by pharmacodynamic synergism. Minor/Significance Unknown.

                • lofepramine

                  lofepramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • loprazolam

                  brimonidine increases effects of loprazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • lorazepam

                  brimonidine increases effects of lorazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • lormetazepam

                  brimonidine increases effects of lormetazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • loxapine

                  brimonidine increases effects of loxapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • loxapine inhaled

                  brimonidine increases effects of loxapine inhaled by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • maprotiline

                  maprotiline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • mecamylamine

                  brimonidine increases effects of mecamylamine by pharmacodynamic synergism. Minor/Significance Unknown.

                • meperidine

                  brimonidine increases effects of meperidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • meprobamate

                  brimonidine increases effects of meprobamate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • methadone

                  brimonidine increases effects of methadone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • methyclothiazide

                  brimonidine increases effects of methyclothiazide by pharmacodynamic synergism. Minor/Significance Unknown.

                • metolazone

                  brimonidine increases effects of metolazone by pharmacodynamic synergism. Minor/Significance Unknown.

                • metoprolol

                  brimonidine increases effects of metoprolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • metyrosine

                  brimonidine increases effects of metyrosine by pharmacodynamic synergism. Minor/Significance Unknown.

                • midazolam

                  brimonidine increases effects of midazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • minoxidil

                  brimonidine increases effects of minoxidil by pharmacodynamic synergism. Minor/Significance Unknown.

                • moexipril

                  brimonidine increases effects of moexipril by pharmacodynamic synergism. Minor/Significance Unknown.

                • morphine

                  brimonidine increases effects of morphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • moxisylyte

                  brimonidine increases effects of moxisylyte by pharmacodynamic synergism. Minor/Significance Unknown.

                • moxonidine

                  brimonidine increases effects of moxonidine by pharmacodynamic synergism. Minor/Significance Unknown.

                • nadolol

                  brimonidine increases effects of nadolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • nalbuphine

                  brimonidine increases effects of nalbuphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • nebivolol

                  brimonidine increases effects of nebivolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • nicardipine

                  brimonidine increases effects of nicardipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • nifedipine

                  brimonidine increases effects of nifedipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • nisoldipine

                  brimonidine increases effects of nisoldipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • nortriptyline

                  nortriptyline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • olanzapine

                  brimonidine increases effects of olanzapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • opium tincture

                  brimonidine increases effects of opium tincture by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • oxazepam

                  brimonidine increases effects of oxazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • oxycodone

                  brimonidine increases effects of oxycodone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • oxymorphone

                  brimonidine increases effects of oxymorphone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • paliperidone

                  brimonidine increases effects of paliperidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • papaveretum

                  brimonidine increases effects of papaveretum by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • penbutolol

                  brimonidine increases effects of penbutolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • pentazocine

                  brimonidine increases effects of pentazocine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • pentobarbital

                  brimonidine increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • perindopril

                  brimonidine increases effects of perindopril by pharmacodynamic synergism. Minor/Significance Unknown.

                • perphenazine

                  brimonidine increases effects of perphenazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • phenobarbital

                  brimonidine increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • phenoxybenzamine

                  brimonidine increases effects of phenoxybenzamine by pharmacodynamic synergism. Minor/Significance Unknown.

                • phentolamine

                  brimonidine increases effects of phentolamine by pharmacodynamic synergism. Minor/Significance Unknown.

                • pimozide

                  brimonidine increases effects of pimozide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • pindolol

                  brimonidine increases effects of pindolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • prazosin

                  brimonidine increases effects of prazosin by pharmacodynamic synergism. Minor/Significance Unknown.

                • primidone

                  brimonidine increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • prochlorperazine

                  brimonidine increases effects of prochlorperazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • promethazine

                  brimonidine increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • propranolol

                  brimonidine increases effects of propranolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • protriptyline

                  protriptyline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • quazepam

                  brimonidine increases effects of quazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • quetiapine

                  brimonidine increases effects of quetiapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • quinapril

                  brimonidine increases effects of quinapril by pharmacodynamic synergism. Minor/Significance Unknown.

                • ramipril

                  brimonidine increases effects of ramipril by pharmacodynamic synergism. Minor/Significance Unknown.

                • risperidone

                  brimonidine increases effects of risperidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • secobarbital

                  brimonidine increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • silodosin

                  brimonidine increases effects of silodosin by pharmacodynamic synergism. Minor/Significance Unknown.

                • sotalol

                  brimonidine increases effects of sotalol by pharmacodynamic synergism. Minor/Significance Unknown.

                • spironolactone

                  brimonidine increases effects of spironolactone by pharmacodynamic synergism. Minor/Significance Unknown.

                • sufentanil

                  brimonidine increases effects of sufentanil by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • tapentadol

                  brimonidine increases effects of tapentadol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • temazepam

                  brimonidine increases effects of temazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • terazosin

                  brimonidine increases effects of terazosin by pharmacodynamic synergism. Minor/Significance Unknown.

                • thioridazine

                  brimonidine increases effects of thioridazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • thiothixene

                  brimonidine increases effects of thiothixene by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • timolol

                  brimonidine increases effects of timolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • torsemide

                  brimonidine increases effects of torsemide by pharmacodynamic synergism. Minor/Significance Unknown.

                • tramadol

                  brimonidine increases effects of tramadol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • trandolapril

                  brimonidine increases effects of trandolapril by pharmacodynamic synergism. Minor/Significance Unknown.

                • trazodone

                  trazodone decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • treprostinil

                  brimonidine increases effects of treprostinil by pharmacodynamic synergism. Minor/Significance Unknown.

                • triamterene

                  brimonidine increases effects of triamterene by pharmacodynamic synergism. Minor/Significance Unknown.

                • triazolam

                  brimonidine increases effects of triazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • triclofos

                  brimonidine increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • trifluoperazine

                  brimonidine increases effects of trifluoperazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • trimipramine

                  trimipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

                • triprolidine

                  brimonidine increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • verapamil

                  brimonidine increases effects of verapamil by pharmacodynamic synergism. Minor/Significance Unknown.

                • ziprasidone

                  brimonidine increases effects of ziprasidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                • zotepine

                  brimonidine increases effects of zotepine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

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                Adverse Effects

                Frequency Not Defined

                Oral dryness

                Conjunctival hyperemia

                Allergic conjunctivitis

                Eye pruritus

                Rash

                Photophobia

                Headache

                Fatigue

                Dizziness

                Dyspepsia

                Blepharitis

                Eye discharge

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                Warnings

                Contraindications

                Hypersensitivity to product or components

                Children <2 years (0.1-0.15% ophthalmic solution)

                Cautions

                Remove contact lenses before instilling eye drops; wait 15 min before reinserting contact lenses

                If >1 ophthalmic product is being administered, wait 5 minutes between instilling eye drops

                May potentiate syndromes associated with vascular insufficiency; caution with depression, cerebral or coronary insufficiency, Raynaud phenomenon, orthostatic hypotension, or thromboangiitis obliterans

                Although brimonidine ophthalmic had minimal effect on the blood pressure of patients in clinical studies, caution with severe cardiovascular disease

                Bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products; instruct patients on how to avoid contamination

                Drug interaction overview

                • Because brimonidine ophthalmic may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with advised
                • Although specific drug interaction studies have not been conducted with brimonidine ophthalmic, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered
                • Tricyclic antidepressants (TCAs) have been reported to blunt the hypotensive effect of systemic clonidine; unknown whether the concurrent use TCAs with brimonidine ophthalmic can interfere with IOP lowering effect
                • MAOIs may theoretically interfere with the metabolism of brimonidine and potentially result in increased systemic effects (eg, hypotension); advise caution to patients taking MAO inhibitors
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                Pregnancy & Lactation

                Pregnancy Category: B

                Lactation: It is not known whether this drug is excreted in milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Open-Angle Glaucoma or Ocular Hypertension

                • Alpha-2 adrenergic receptor agonist; decreases aqueous humor secretion, increases uveoscleral outflow

                Ocular Redness

                • Dilutes alpha-2 receptor agonist; rapidly eliminates redness along the bulbar conjunctival microvasculature

                Pharmacokinetics

                Onset of action: 2hr (peak effect)

                Half-Life: 2 hr

                Peak plasma time: 0.5-2.5 hr

                Metabolism: Liver

                Excretion: urine (74%)

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                Images

                BRAND FORM. UNIT PRICE PILL IMAGE
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.15 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.15 % drops
                brimonidine ophthalmic (eye)
                -
                		0.15 % drops
                brimonidine ophthalmic (eye)
                -
                		0.15 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                brimonidine ophthalmic (eye)
                -
                		0.15 % drops
                brimonidine ophthalmic (eye)
                -
                		0.15 % drops
                brimonidine ophthalmic (eye)
                -
                		0.2 % drops
                Alphagan P ophthalmic (eye)
                -
                		0.1 % drops
                Alphagan P ophthalmic (eye)
                -
                		0.1 % drops
                Alphagan P ophthalmic (eye)
                -
                		0.1 % drops
                Alphagan P ophthalmic (eye)
                -
                		0.15 % drops
                Alphagan P ophthalmic (eye)
                -
                		0.15 % drops
                Alphagan P ophthalmic (eye)
                -
                		0.15 % drops
                Mirvaso topical
                -
                		0.33 % gel

                Copyright © 2010 First DataBank, Inc.

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                Patient Handout

                Select a drug:
                Patient Education
                brimonidine ophthalmic (eye)

                BRIMONIDINE 0.025% SOLUTION - OPHTHALMIC

                (bri-MON-i-deen)

                COMMON BRAND NAME(S): Lumify

                USES: Brimonidine is used to relieve redness in the eyes caused by minor eye irritations (such as smog, swimming, dust, or smoke).

                HOW TO USE: Read and follow all directions on the product package before using this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, use it as directed.Use this medication in the affected eye(s) every 6 to 8 hours as needed. Do not use more than 4 times a day.To apply eye drops, wash hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.If you are wearing contact lenses, remove them before using eye drops. Wait at least 10 minutes before replacing your contact lenses.Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward, gently close your eyes, and place one finger at the corner of your eye (near the nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes. This will prevent the medication from draining out. Try not to blink or rub your eye. Repeat these steps for your other eye if needed. Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (such as drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.Do not use if the solution has changed color or is cloudy.Tell your doctor if your condition lasts for more than 3 days or if it gets worse (such as continued eye redness/irritation, eye pain, vision changes). If you think you may have a serious medical problem, get medical help right away.

                SIDE EFFECTS: If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                PRECAUTIONS: Before using brimonidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you can do it safely.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

                DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

                OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

                NOTES: Keep all regular medical and lab appointments.

                MISSED DOSE: Not applicable.

                STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

                Information last revised December 2022. Copyright(c) 2023 First Databank, Inc.

                IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                Formulary

                FormularyPatient Discounts

                Adding plans allows you to compare formulary status to other drugs in the same class.

                To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                Create Your List of Plans

                Adding plans allows you to:

                • View the formulary and any restrictions for each plan.
                • Manage and view all your plans together – even plans in different states.
                • Compare formulary status to other drugs in the same class.
                • Access your plan list on any device – mobile or desktop.

                The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                View explanations for tiers and restrictions
                Tier Description
                1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                NC NOT COVERED – Drugs that are not covered by the plan.
                Code Definition
                PA Prior Authorization
                Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                QL Quantity Limits
                Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                ST Step Therapy
                Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                OR Other Restrictions
                Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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