brimonidine (Rx, OTC)

Brand and Other Names:Alphagan P, Qoliana, more...Lumify

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution (Rx)

  • 0.1% (Alphagan P)
  • 0.15% (Alphagan P, Qoliana, generic)

ophthalmic solution (OTC)

  • 0.025% (Lumify)

Elevated Intraocular Pressure

Indicated to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

Alphagan P, Qoliana: 1 gtt in affected eye(s) q8hr

Ocular Redness

Indicated to relieve ocular redness caused by minor eye irritations

Lumify: Instill 1 gtt in affected eye(s) q6-8hr

Optic Neuropathy (Orphan)

Treatment of anterior ischemic optic neuropathy

Orphan indication sponsor

  • Allergan, Inc; 2525 Dupont Drive, P.O. Box 19534; Irvine, CA 92713

Graft vs Host Disease (Orphan)

Orphan designation for ocular GVHD

Sponsor

  • Ocugen, Inc; 5 Great Valley Parkway, Suite 160; Malvern, Pennsylvania 19355

Dosage Forms & Strengths

ophthalmic solution (Rx)

  • 0.1% (Alphagan P)
  • 0.15% (Alphagan P, Qoliana, generic)

ophthalmic solution (OTC)

  • 0.025% (Lumify)

Elevated Intraocular Pressure

Indicated to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

<2 years: Contraindicated

≥2 years: Alphagan P, Qoliana: 1 gtt in affected eye(s) q8hr

Ocular Redness

Indicated to relieve ocular redness caused by minor eye irritations in adults and children aged ≥5 yr

<5 years (Lumify): Safety and efficacy not established

≥5 years (Lumify): Instill 1 gtt in affected eye(s) q6-8hr

Next:

Interactions

Interaction Checker

and brimonidine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (9)

            • isocarboxazid

              isocarboxazid, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

            • linezolid

              linezolid, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

            • phenelzine

              phenelzine, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

            • procarbazine

              procarbazine, brimonidine. Mechanism: unknown. Contraindicated.

            • rasagiline

              rasagiline, brimonidine. Mechanism: unknown. Contraindicated. Brimonidine should not be used in patients receiving MAO inhibitors.

            • selegiline

              selegiline, brimonidine. Mechanism: unknown. Contraindicated. Coadministration is contraindicated.

            • selegiline transdermal

              selegiline transdermal, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

            • thalidomide

              brimonidine and thalidomide both increase sedation. Contraindicated.

            • tranylcypromine

              tranylcypromine, brimonidine. Mechanism: unknown. Contraindicated. Contraindicated in mfr prescribing info.

            Serious - Use Alternative (19)

            • alfentanil

              brimonidine and alfentanil both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • buprenorphine

              brimonidine and buprenorphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • buprenorphine buccal

              brimonidine and buprenorphine buccal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • buprenorphine subdermal implant

              brimonidine and buprenorphine subdermal implant both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • buprenorphine transdermal

              brimonidine and buprenorphine transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • buprenorphine, long-acting injection

              brimonidine and buprenorphine, long-acting injection both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • codeine

              brimonidine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • fentanyl

              brimonidine and fentanyl both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • fentanyl intranasal

              brimonidine and fentanyl intranasal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • fentanyl iontophoretic transdermal system

              brimonidine and fentanyl iontophoretic transdermal system both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • fentanyl transdermal

              brimonidine and fentanyl transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • fentanyl transmucosal

              brimonidine and fentanyl transmucosal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • hydrocodone

              brimonidine and hydrocodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • hydromorphone

              brimonidine and hydromorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • methadone

              brimonidine and methadone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • morphine

              brimonidine and morphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • oxycodone

              brimonidine and oxycodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • oxymorphone

              brimonidine and oxymorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • remifentanil

              brimonidine and remifentanil both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            Monitor Closely (172)

            • acetaminophen/phenyltoloxamine

              brimonidine and acetaminophen/phenyltoloxamine both increase sedation. Use Caution/Monitor.

            • acrivastine

              acrivastine and brimonidine both increase sedation. Use Caution/Monitor.

            • alprazolam

              brimonidine and alprazolam both increase sedation. Use Caution/Monitor.

            • amifostine

              amifostine, brimonidine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.

            • amisulpride

              amisulpride and brimonidine both increase sedation. Use Caution/Monitor.

            • amitriptyline

              brimonidine and amitriptyline both increase sedation. Use Caution/Monitor.

            • amobarbital

              brimonidine and amobarbital both increase sedation. Use Caution/Monitor.

            • amoxapine

              brimonidine and amoxapine both increase sedation. Use Caution/Monitor.

            • aripiprazole

              brimonidine and aripiprazole both increase sedation. Use Caution/Monitor.

            • asenapine

              asenapine and brimonidine both increase sedation. Use Caution/Monitor.

            • asenapine transdermal

              asenapine transdermal and brimonidine both increase sedation. Use Caution/Monitor.

            • avapritinib

              avapritinib and brimonidine both increase sedation. Use Caution/Monitor.

              brimonidine and avapritinib both increase sedation. Use Caution/Monitor.

            • baclofen

              brimonidine and baclofen both increase sedation. Use Caution/Monitor.

            • benzhydrocodone/acetaminophen

              benzhydrocodone/acetaminophen and brimonidine both increase sedation. Use Caution/Monitor.

            • brexanolone

              brimonidine and brexanolone both increase sedation. Use Caution/Monitor.

            • brexpiprazole

              brexpiprazole and brimonidine both increase sedation. Use Caution/Monitor.

              brimonidine and brexpiprazole both increase sedation. Use Caution/Monitor.

            • brivaracetam

              brimonidine and brivaracetam both increase sedation. Use Caution/Monitor.

              brivaracetam and brimonidine both increase sedation. Use Caution/Monitor.

            • brompheniramine

              brimonidine and brompheniramine both increase sedation. Use Caution/Monitor.

            • buprenorphine subdermal implant

              buprenorphine subdermal implant and brimonidine both increase sedation. Use Caution/Monitor.

            • butabarbital

              brimonidine and butabarbital both increase sedation. Use Caution/Monitor.

            • butalbital

              brimonidine and butalbital both increase sedation. Use Caution/Monitor.

            • butorphanol

              brimonidine and butorphanol both increase sedation. Use Caution/Monitor.

            • candesartan

              brimonidine increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor.

            • carbinoxamine

              brimonidine and carbinoxamine both increase sedation. Use Caution/Monitor.

            • cariprazine

              brimonidine and cariprazine both increase sedation. Use Caution/Monitor.

            • carisoprodol

              brimonidine and carisoprodol both increase sedation. Use Caution/Monitor.

            • cenobamate

              brimonidine and cenobamate both increase sedation. Use Caution/Monitor.

            • cetirizine

              brimonidine and cetirizine both increase sedation. Use Caution/Monitor.

            • chlordiazepoxide

              brimonidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

            • chlorpheniramine

              brimonidine and chlorpheniramine both increase sedation. Use Caution/Monitor.

            • chlorpromazine

              brimonidine and chlorpromazine both increase sedation. Use Caution/Monitor.

            • chlorzoxazone

              brimonidine and chlorzoxazone both increase sedation. Use Caution/Monitor.

            • clemastine

              brimonidine and clemastine both increase sedation. Use Caution/Monitor.

            • clobazam

              brimonidine and clobazam both increase sedation. Use Caution/Monitor.

            • clomipramine

              brimonidine and clomipramine both increase sedation. Use Caution/Monitor.

            • clonazepam

              brimonidine and clonazepam both increase sedation. Use Caution/Monitor.

            • clonidine

              brimonidine and clonidine both increase sedation. Use Caution/Monitor.

            • clorazepate

              brimonidine and clorazepate both increase sedation. Use Caution/Monitor.

            • clozapine

              brimonidine and clozapine both increase sedation. Use Caution/Monitor.

            • cyclobenzaprine

              brimonidine and cyclobenzaprine both increase sedation. Use Caution/Monitor.

            • cyproheptadine

              brimonidine and cyproheptadine both increase sedation. Use Caution/Monitor.

            • dantrolene

              brimonidine and dantrolene both increase sedation. Use Caution/Monitor.

            • daridorexant

              brimonidine and daridorexant both increase sedation. Use Caution/Monitor.

            • desflurane

              brimonidine and desflurane both increase sedation. Use Caution/Monitor.

            • desipramine

              brimonidine and desipramine both increase sedation. Use Caution/Monitor.

            • deutetrabenazine

              brimonidine and deutetrabenazine both increase sedation. Use Caution/Monitor.

            • dexbrompheniramine

              brimonidine and dexbrompheniramine both increase sedation. Use Caution/Monitor.

            • dexchlorpheniramine

              brimonidine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

            • diazepam

              brimonidine and diazepam both increase sedation. Use Caution/Monitor.

            • difenoxin hcl

              brimonidine and difenoxin hcl both increase sedation. Use Caution/Monitor.

            • digoxin

              brimonidine increases effects of digoxin by pharmacodynamic synergism. Use Caution/Monitor.

            • dimenhydrinate

              brimonidine and dimenhydrinate both increase sedation. Use Caution/Monitor.

            • diphenhydramine

              brimonidine and diphenhydramine both increase sedation. Use Caution/Monitor.

            • diphenoxylate hcl

              brimonidine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

            • doxepin

              brimonidine and doxepin both increase sedation. Use Caution/Monitor.

            • doxylamine

              brimonidine and doxylamine both increase sedation. Use Caution/Monitor.

            • droperidol

              brimonidine and droperidol both increase sedation. Use Caution/Monitor.

            • efavirenz

              brimonidine and efavirenz both increase sedation. Use Caution/Monitor.

            • entacapone

              brimonidine and entacapone both increase sedation. Use Caution/Monitor.

            • eprosartan

              brimonidine increases effects of eprosartan by pharmacodynamic synergism. Use Caution/Monitor.

            • esketamine intranasal

              esketamine intranasal, brimonidine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

            • estazolam

              brimonidine and estazolam both increase sedation. Use Caution/Monitor.

            • eszopiclone

              brimonidine and eszopiclone both increase sedation. Use Caution/Monitor.

            • ethanol

              brimonidine and ethanol both increase sedation. Use Caution/Monitor.

            • ethosuximide

              brimonidine and ethosuximide both increase sedation. Use Caution/Monitor.

            • ethotoin

              brimonidine and ethotoin both increase sedation. Use Caution/Monitor.

            • felbamate

              brimonidine and felbamate both increase sedation. Use Caution/Monitor.

            • fenfluramine

              brimonidine and fenfluramine both increase sedation. Use Caution/Monitor.

            • fexofenadine

              brimonidine and fexofenadine both increase sedation. Use Caution/Monitor.

            • flibanserin

              brimonidine and flibanserin both increase sedation. Use Caution/Monitor.

            • fluphenazine

              brimonidine and fluphenazine both increase sedation. Use Caution/Monitor.

            • flurazepam

              brimonidine and flurazepam both increase sedation. Use Caution/Monitor.

            • gabapentin

              brimonidine and gabapentin both increase sedation. Use Caution/Monitor.

            • ganaxolone

              brimonidine and ganaxolone both increase sedation. Use Caution/Monitor.

            • guanfacine

              brimonidine and guanfacine both increase sedation. Use Caution/Monitor.

            • haloperidol

              brimonidine and haloperidol both increase sedation. Use Caution/Monitor.

            • hydroxyzine

              brimonidine and hydroxyzine both increase sedation. Use Caution/Monitor.

            • iloperidone

              brimonidine and iloperidone both increase sedation. Use Caution/Monitor.

            • imipramine

              brimonidine and imipramine both increase sedation. Use Caution/Monitor.

            • irbesartan

              brimonidine increases effects of irbesartan by pharmacodynamic synergism. Use Caution/Monitor.

            • isoflurane

              brimonidine and isoflurane both increase sedation. Use Caution/Monitor.

            • ketamine

              brimonidine and ketamine both increase sedation. Use Caution/Monitor.

            • ketotifen, drug-eluting contact lens

              brimonidine and ketotifen, drug-eluting contact lens both increase sedation. Use Caution/Monitor.

            • lamotrigine

              brimonidine and lamotrigine both increase sedation. Use Caution/Monitor.

            • lasmiditan

              lasmiditan, brimonidine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

            • lemborexant

              brimonidine and lemborexant both increase sedation. Use Caution/Monitor.

            • levetiracetam

              brimonidine and levetiracetam both increase sedation. Use Caution/Monitor.

            • levocetirizine

              brimonidine and levocetirizine both increase sedation. Use Caution/Monitor.

            • levorphanol

              brimonidine and levorphanol both increase sedation. Use Caution/Monitor.

            • loratadine

              brimonidine and loratadine both increase sedation. Use Caution/Monitor.

            • lorazepam

              brimonidine and lorazepam both increase sedation. Use Caution/Monitor.

            • losartan

              brimonidine increases effects of losartan by pharmacodynamic synergism. Use Caution/Monitor.

            • loxapine

              brimonidine and loxapine both increase sedation. Use Caution/Monitor.

            • lumateperone

              brimonidine and lumateperone both increase sedation. Use Caution/Monitor.

            • lurasidone

              lurasidone, brimonidine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased sedation.

              brimonidine and lurasidone both increase sedation. Use Caution/Monitor.

            • maprotiline

              brimonidine and maprotiline both increase sedation. Use Caution/Monitor.

            • meclizine

              brimonidine and meclizine both increase sedation. Use Caution/Monitor.

            • meperidine

              brimonidine and meperidine both increase sedation. Use Caution/Monitor.

            • meprobamate

              brimonidine and meprobamate both increase sedation. Use Caution/Monitor.

            • metaxalone

              brimonidine and metaxalone both increase sedation. Use Caution/Monitor.

            • methocarbamol

              brimonidine and methocarbamol both increase sedation. Use Caution/Monitor.

            • methohexital

              brimonidine and methohexital both increase sedation. Use Caution/Monitor.

            • methsuximide

              brimonidine and methsuximide both increase sedation. Use Caution/Monitor.

            • midazolam

              brimonidine and midazolam both increase sedation. Use Caution/Monitor.

            • mirtazapine

              brimonidine and mirtazapine both increase sedation. Use Caution/Monitor.

            • molindone

              brimonidine and molindone both increase sedation. Use Caution/Monitor.

            • nalbuphine

              brimonidine and nalbuphine both increase sedation. Use Caution/Monitor.

            • nitroglycerin rectal

              nitroglycerin rectal, brimonidine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Observe for possible additive hypotensive effects during concomitant use. .

            • nitrous oxide

              brimonidine and nitrous oxide both increase sedation. Use Caution/Monitor.

            • nortriptyline

              brimonidine and nortriptyline both increase sedation. Use Caution/Monitor.

            • olanzapine

              brimonidine and olanzapine both increase sedation. Use Caution/Monitor.

            • oliceridine

              brimonidine and oliceridine both increase sedation. Use Caution/Monitor.

            • olmesartan

              brimonidine increases effects of olmesartan by pharmacodynamic synergism. Use Caution/Monitor.

            • olopatadine intranasal

              brimonidine and olopatadine intranasal both increase sedation. Use Caution/Monitor.

            • opicapone

              brimonidine and opicapone both increase sedation. Use Caution/Monitor.

            • opium tincture

              brimonidine and opium tincture both increase sedation. Use Caution/Monitor.

            • orphenadrine

              brimonidine and orphenadrine both increase sedation. Use Caution/Monitor.

            • oxazepam

              brimonidine and oxazepam both increase sedation. Use Caution/Monitor.

            • paliperidone

              brimonidine and paliperidone both increase sedation. Use Caution/Monitor.

            • pentazocine

              brimonidine and pentazocine both increase sedation. Use Caution/Monitor.

            • pentobarbital

              brimonidine and pentobarbital both increase sedation. Use Caution/Monitor.

            • perampanel

              brimonidine and perampanel both increase sedation. Use Caution/Monitor.

            • perphenazine

              brimonidine and perphenazine both increase sedation. Use Caution/Monitor.

            • pheniramine

              brimonidine and pheniramine both increase sedation. Use Caution/Monitor.

            • phenobarbital

              brimonidine and phenobarbital both increase sedation. Use Caution/Monitor.

            • pimozide

              brimonidine and pimozide both increase sedation. Use Caution/Monitor.

            • pomalidomide

              brimonidine and pomalidomide both increase sedation. Use Caution/Monitor.

            • pregabalin

              brimonidine and pregabalin both increase sedation. Use Caution/Monitor.

            • primidone

              brimonidine and primidone both increase sedation. Use Caution/Monitor.

            • prochlorperazine

              brimonidine and prochlorperazine both increase sedation. Use Caution/Monitor.

            • promethazine

              brimonidine and promethazine both increase sedation. Use Caution/Monitor.

            • propofol

              brimonidine and propofol both increase sedation. Use Caution/Monitor.

            • protriptyline

              brimonidine and protriptyline both increase sedation. Use Caution/Monitor.

            • pyrilamine

              brimonidine and pyrilamine both increase sedation. Use Caution/Monitor.

            • quazepam

              brimonidine and quazepam both increase sedation. Use Caution/Monitor.

            • quetiapine

              brimonidine and quetiapine both increase sedation. Use Caution/Monitor.

            • ramelteon

              brimonidine and ramelteon both increase sedation. Use Caution/Monitor.

            • remimazolam

              brimonidine and remimazolam both increase sedation. Use Caution/Monitor.

            • reserpine

              brimonidine and reserpine both increase sedation. Use Caution/Monitor.

            • risperidone

              brimonidine and risperidone both increase sedation. Use Caution/Monitor.

            • sacubitril/valsartan

              brimonidine increases effects of sacubitril/valsartan by pharmacodynamic synergism. Use Caution/Monitor.

            • scopolamine

              brimonidine and scopolamine both increase sedation. Use Caution/Monitor.

            • sevoflurane

              brimonidine and sevoflurane both increase sedation. Use Caution/Monitor.

            • sodium oxybate

              brimonidine and sodium oxybate both increase sedation. Use Caution/Monitor.

            • stiripentol

              stiripentol, brimonidine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

            • sufentanil

              brimonidine and sufentanil both increase sedation. Use Caution/Monitor.

            • sufentanil SL

              brimonidine and sufentanil SL both increase sedation. Use Caution/Monitor.

            • suvorexant

              brimonidine and suvorexant both increase sedation. Use Caution/Monitor.

            • tapentadol

              brimonidine and tapentadol both increase sedation. Use Caution/Monitor.

            • tasimelteon

              brimonidine and tasimelteon both increase sedation. Use Caution/Monitor.

            • telmisartan

              brimonidine increases effects of telmisartan by pharmacodynamic synergism. Use Caution/Monitor.

            • temazepam

              brimonidine and temazepam both increase sedation. Use Caution/Monitor.

            • tetrabenazine

              brimonidine and tetrabenazine both increase sedation. Use Caution/Monitor.

            • thioridazine

              brimonidine and thioridazine both increase sedation. Use Caution/Monitor.

            • thiothixene

              brimonidine and thiothixene both increase sedation. Use Caution/Monitor.

            • tiagabine

              brimonidine and tiagabine both increase sedation. Use Caution/Monitor.

            • tizanidine

              brimonidine and tizanidine both increase sedation. Use Caution/Monitor.

            • tolcapone

              brimonidine and tolcapone both increase sedation. Use Caution/Monitor.

            • topiramate

              brimonidine and topiramate both increase sedation. Use Caution/Monitor.

            • tramadol

              brimonidine and tramadol both increase sedation. Use Caution/Monitor.

            • trazodone

              brimonidine and trazodone both increase sedation. Use Caution/Monitor.

            • triazolam

              brimonidine and triazolam both increase sedation. Use Caution/Monitor.

            • trifluoperazine

              brimonidine and trifluoperazine both increase sedation. Use Caution/Monitor.

            • triprolidine

              brimonidine and triprolidine both increase sedation. Use Caution/Monitor.

            • valproic acid

              brimonidine and valproic acid both increase sedation. Use Caution/Monitor.

            • valsartan

              brimonidine increases effects of valsartan by pharmacodynamic synergism. Use Caution/Monitor.

            • vigabatrin

              brimonidine and vigabatrin both increase sedation. Use Caution/Monitor.

            • zaleplon

              brimonidine and zaleplon both increase sedation. Use Caution/Monitor.

            • ziconotide

              brimonidine and ziconotide both increase sedation. Use Caution/Monitor.

            • ziprasidone

              brimonidine and ziprasidone both increase sedation. Use Caution/Monitor.

            • zolpidem

              brimonidine and zolpidem both increase sedation. Use Caution/Monitor.

            • zonisamide

              brimonidine and zonisamide both increase sedation. Use Caution/Monitor.

            Minor (177)

            • acebutolol

              brimonidine increases effects of acebutolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • alfentanil

              brimonidine increases effects of alfentanil by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • alfuzosin

              brimonidine increases effects of alfuzosin by pharmacodynamic synergism. Minor/Significance Unknown.

            • alprazolam

              brimonidine increases effects of alprazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • amiloride

              brimonidine increases effects of amiloride by pharmacodynamic synergism. Minor/Significance Unknown.

            • amitriptyline

              amitriptyline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • amlodipine

              brimonidine increases effects of amlodipine by pharmacodynamic synergism. Minor/Significance Unknown.

            • amobarbital

              brimonidine increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • amoxapine

              amoxapine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • aripiprazole

              brimonidine increases effects of aripiprazole by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • asenapine

              brimonidine increases effects of asenapine by pharmacodynamic synergism. Minor/Significance Unknown.

            • atenolol

              brimonidine increases effects of atenolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • azelastine

              brimonidine increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • belladonna and opium

              brimonidine increases effects of belladonna and opium by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • benazepril

              brimonidine increases effects of benazepril by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.

            • bendroflumethiazide

              brimonidine increases effects of bendroflumethiazide by pharmacodynamic synergism. Minor/Significance Unknown.

            • benperidol

              brimonidine increases effects of benperidol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • betaxolol

              brimonidine increases effects of betaxolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • bisoprolol

              brimonidine increases effects of bisoprolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • bosentan

              brimonidine increases effects of bosentan by pharmacodynamic synergism. Minor/Significance Unknown.

            • brompheniramine

              brimonidine increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • bumetanide

              brimonidine increases effects of bumetanide by pharmacodynamic synergism. Minor/Significance Unknown.

            • buprenorphine

              brimonidine increases effects of buprenorphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • buprenorphine buccal

              brimonidine increases effects of buprenorphine buccal by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • butabarbital

              brimonidine increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • butalbital

              brimonidine increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • butorphanol

              brimonidine increases effects of butorphanol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • captopril

              brimonidine increases effects of captopril by pharmacodynamic synergism. Minor/Significance Unknown. Both drugs lower blood pressure. Monitor blood pressure.

            • carbinoxamine

              brimonidine increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • carvedilol

              brimonidine increases effects of carvedilol by pharmacodynamic synergism. Minor/Significance Unknown.

            • celiprolol

              brimonidine increases effects of celiprolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • chloral hydrate

              brimonidine increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • chlordiazepoxide

              brimonidine increases effects of chlordiazepoxide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • chlorothiazide

              brimonidine increases effects of chlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown.

            • chlorpheniramine

              brimonidine increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • chlorpromazine

              brimonidine increases effects of chlorpromazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • chlorthalidone

              brimonidine increases effects of chlorthalidone by pharmacodynamic synergism. Minor/Significance Unknown.

            • cinnarizine

              brimonidine increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • clemastine

              brimonidine increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • clevidipine

              brimonidine increases effects of clevidipine by pharmacodynamic synergism. Minor/Significance Unknown.

            • clomipramine

              clomipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • clonazepam

              brimonidine increases effects of clonazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • clonidine

              brimonidine increases effects of clonidine by pharmacodynamic synergism. Minor/Significance Unknown.

            • clorazepate

              brimonidine increases effects of clorazepate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • clozapine

              brimonidine increases effects of clozapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • codeine

              brimonidine increases effects of codeine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • cyclizine

              brimonidine increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • cyclopenthiazide

              brimonidine increases effects of cyclopenthiazide by pharmacodynamic synergism. Minor/Significance Unknown.

            • cyproheptadine

              brimonidine increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • desipramine

              desipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • dexchlorpheniramine

              brimonidine increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • dexmedetomidine

              brimonidine increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • dextromoramide

              brimonidine increases effects of dextromoramide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • diamorphine

              brimonidine increases effects of diamorphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • diazepam

              brimonidine increases effects of diazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • difenoxin hcl

              brimonidine increases effects of difenoxin hcl by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • diltiazem

              brimonidine increases effects of diltiazem by pharmacodynamic synergism. Minor/Significance Unknown.

            • dimenhydrinate

              brimonidine increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • diphenhydramine

              brimonidine increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • diphenoxylate hcl

              brimonidine increases effects of diphenoxylate hcl by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • dipipanone

              brimonidine increases effects of dipipanone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • doxazosin

              brimonidine increases effects of doxazosin by pharmacodynamic synergism. Minor/Significance Unknown.

            • doxepin

              doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • doxylamine

              brimonidine increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • droperidol

              brimonidine increases effects of droperidol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • drospirenone

              brimonidine increases effects of drospirenone by pharmacodynamic synergism. Minor/Significance Unknown.

            • enalapril

              brimonidine increases effects of enalapril by pharmacodynamic synergism. Minor/Significance Unknown.

            • eplerenone

              brimonidine increases effects of eplerenone by pharmacodynamic synergism. Minor/Significance Unknown.

            • epoprostenol

              brimonidine increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.

            • esmolol

              brimonidine increases effects of esmolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • estazolam

              brimonidine increases effects of estazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • ethacrynic acid

              brimonidine increases effects of ethacrynic acid by pharmacodynamic synergism. Minor/Significance Unknown.

            • ethanol

              brimonidine increases effects of ethanol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • etomidate

              brimonidine increases effects of etomidate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • felodipine

              brimonidine increases effects of felodipine by pharmacodynamic synergism. Minor/Significance Unknown.

            • fenoldopam

              brimonidine increases effects of fenoldopam by pharmacodynamic synergism. Minor/Significance Unknown.

            • fluphenazine

              brimonidine increases effects of fluphenazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • flurazepam

              brimonidine increases effects of flurazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • fosinopril

              brimonidine increases effects of fosinopril by pharmacodynamic synergism. Minor/Significance Unknown.

            • furosemide

              brimonidine increases effects of furosemide by pharmacodynamic synergism. Minor/Significance Unknown.

            • guanfacine

              brimonidine increases effects of guanfacine by pharmacodynamic synergism. Minor/Significance Unknown.

            • haloperidol

              brimonidine increases effects of haloperidol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • hydralazine

              brimonidine increases effects of hydralazine by pharmacodynamic synergism. Minor/Significance Unknown.

            • hydrochlorothiazide

              brimonidine increases effects of hydrochlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown.

            • hydromorphone

              brimonidine increases effects of hydromorphone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • hydroxyzine

              brimonidine increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • iloperidone

              brimonidine increases effects of iloperidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • iloprost

              brimonidine increases effects of iloprost by pharmacodynamic synergism. Minor/Significance Unknown.

            • imidapril

              brimonidine increases effects of imidapril by pharmacodynamic synergism. Minor/Significance Unknown.

            • imipramine

              imipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • indapamide

              brimonidine increases effects of indapamide by pharmacodynamic synergism. Minor/Significance Unknown.

            • isradipine

              brimonidine increases effects of isradipine by pharmacodynamic synergism. Minor/Significance Unknown.

            • ketanserin

              brimonidine increases effects of ketanserin by pharmacodynamic synergism. Minor/Significance Unknown.

            • labetalol

              brimonidine increases effects of labetalol by pharmacodynamic synergism. Minor/Significance Unknown.

            • levorphanol

              brimonidine increases effects of levorphanol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • lisinopril

              brimonidine increases effects of lisinopril by pharmacodynamic synergism. Minor/Significance Unknown.

            • lofepramine

              lofepramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • loprazolam

              brimonidine increases effects of loprazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • lorazepam

              brimonidine increases effects of lorazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • lormetazepam

              brimonidine increases effects of lormetazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • loxapine

              brimonidine increases effects of loxapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • loxapine inhaled

              brimonidine increases effects of loxapine inhaled by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • maprotiline

              maprotiline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • mecamylamine

              brimonidine increases effects of mecamylamine by pharmacodynamic synergism. Minor/Significance Unknown.

            • meperidine

              brimonidine increases effects of meperidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • meprobamate

              brimonidine increases effects of meprobamate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • methadone

              brimonidine increases effects of methadone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • methyclothiazide

              brimonidine increases effects of methyclothiazide by pharmacodynamic synergism. Minor/Significance Unknown.

            • metolazone

              brimonidine increases effects of metolazone by pharmacodynamic synergism. Minor/Significance Unknown.

            • metoprolol

              brimonidine increases effects of metoprolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • metyrosine

              brimonidine increases effects of metyrosine by pharmacodynamic synergism. Minor/Significance Unknown.

            • midazolam

              brimonidine increases effects of midazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • minoxidil

              brimonidine increases effects of minoxidil by pharmacodynamic synergism. Minor/Significance Unknown.

            • moexipril

              brimonidine increases effects of moexipril by pharmacodynamic synergism. Minor/Significance Unknown.

            • morphine

              brimonidine increases effects of morphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • moxisylyte

              brimonidine increases effects of moxisylyte by pharmacodynamic synergism. Minor/Significance Unknown.

            • moxonidine

              brimonidine increases effects of moxonidine by pharmacodynamic synergism. Minor/Significance Unknown.

            • nadolol

              brimonidine increases effects of nadolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • nalbuphine

              brimonidine increases effects of nalbuphine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • nebivolol

              brimonidine increases effects of nebivolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • nicardipine

              brimonidine increases effects of nicardipine by pharmacodynamic synergism. Minor/Significance Unknown.

            • nifedipine

              brimonidine increases effects of nifedipine by pharmacodynamic synergism. Minor/Significance Unknown.

            • nisoldipine

              brimonidine increases effects of nisoldipine by pharmacodynamic synergism. Minor/Significance Unknown.

            • nortriptyline

              nortriptyline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • olanzapine

              brimonidine increases effects of olanzapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • opium tincture

              brimonidine increases effects of opium tincture by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • oxazepam

              brimonidine increases effects of oxazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • oxycodone

              brimonidine increases effects of oxycodone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • oxymorphone

              brimonidine increases effects of oxymorphone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • paliperidone

              brimonidine increases effects of paliperidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • papaveretum

              brimonidine increases effects of papaveretum by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • penbutolol

              brimonidine increases effects of penbutolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • pentazocine

              brimonidine increases effects of pentazocine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • pentobarbital

              brimonidine increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • perindopril

              brimonidine increases effects of perindopril by pharmacodynamic synergism. Minor/Significance Unknown.

            • perphenazine

              brimonidine increases effects of perphenazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • phenobarbital

              brimonidine increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • phenoxybenzamine

              brimonidine increases effects of phenoxybenzamine by pharmacodynamic synergism. Minor/Significance Unknown.

            • phentolamine

              brimonidine increases effects of phentolamine by pharmacodynamic synergism. Minor/Significance Unknown.

            • pimozide

              brimonidine increases effects of pimozide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • pindolol

              brimonidine increases effects of pindolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • prazosin

              brimonidine increases effects of prazosin by pharmacodynamic synergism. Minor/Significance Unknown.

            • primidone

              brimonidine increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • prochlorperazine

              brimonidine increases effects of prochlorperazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • promethazine

              brimonidine increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • propranolol

              brimonidine increases effects of propranolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • protriptyline

              protriptyline decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • quazepam

              brimonidine increases effects of quazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • quetiapine

              brimonidine increases effects of quetiapine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • quinapril

              brimonidine increases effects of quinapril by pharmacodynamic synergism. Minor/Significance Unknown.

            • ramipril

              brimonidine increases effects of ramipril by pharmacodynamic synergism. Minor/Significance Unknown.

            • risperidone

              brimonidine increases effects of risperidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • secobarbital

              brimonidine increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • silodosin

              brimonidine increases effects of silodosin by pharmacodynamic synergism. Minor/Significance Unknown.

            • sotalol

              brimonidine increases effects of sotalol by pharmacodynamic synergism. Minor/Significance Unknown.

            • spironolactone

              brimonidine increases effects of spironolactone by pharmacodynamic synergism. Minor/Significance Unknown.

            • sufentanil

              brimonidine increases effects of sufentanil by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • tapentadol

              brimonidine increases effects of tapentadol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • temazepam

              brimonidine increases effects of temazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • terazosin

              brimonidine increases effects of terazosin by pharmacodynamic synergism. Minor/Significance Unknown.

            • thioridazine

              brimonidine increases effects of thioridazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • thiothixene

              brimonidine increases effects of thiothixene by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • timolol

              brimonidine increases effects of timolol by pharmacodynamic synergism. Minor/Significance Unknown.

            • torsemide

              brimonidine increases effects of torsemide by pharmacodynamic synergism. Minor/Significance Unknown.

            • tramadol

              brimonidine increases effects of tramadol by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • trandolapril

              brimonidine increases effects of trandolapril by pharmacodynamic synergism. Minor/Significance Unknown.

            • trazodone

              trazodone decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • treprostinil

              brimonidine increases effects of treprostinil by pharmacodynamic synergism. Minor/Significance Unknown.

            • triamterene

              brimonidine increases effects of triamterene by pharmacodynamic synergism. Minor/Significance Unknown.

            • triazolam

              brimonidine increases effects of triazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • triclofos

              brimonidine increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • trifluoperazine

              brimonidine increases effects of trifluoperazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • trimipramine

              trimipramine decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.

            • triprolidine

              brimonidine increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • verapamil

              brimonidine increases effects of verapamil by pharmacodynamic synergism. Minor/Significance Unknown.

            • ziprasidone

              brimonidine increases effects of ziprasidone by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • zotepine

              brimonidine increases effects of zotepine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

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            Adverse Effects

            Frequency Not Defined

            Oral dryness

            Conjunctival hyperemia

            Allergic conjunctivitis

            Eye pruritus

            Rash

            Photophobia

            Headache

            Fatigue

            Dizziness

            Dyspepsia

            Blepharitis

            Eye discharge

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            Warnings

            Contraindications

            Hypersensitivity to product or components

            Children <2 years (0.1-0.15% ophthalmic solution)

            Cautions

            Remove contact lenses before instilling eye drops; wait 15 min before reinserting contact lenses

            If >1 ophthalmic product is being administered, wait 5 minutes between instilling eye drops

            May potentiate syndromes associated with vascular insufficiency; caution with depression, cerebral or coronary insufficiency, Raynaud phenomenon, orthostatic hypotension, or thromboangiitis obliterans

            Although brimonidine ophthalmic had minimal effect on the blood pressure of patients in clinical studies, caution with severe cardiovascular disease

            Bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products; instruct patients on how to avoid contamination

            Drug interaction overview

            • Because brimonidine ophthalmic may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with advised
            • Although specific drug interaction studies have not been conducted with brimonidine ophthalmic, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered
            • Tricyclic antidepressants (TCAs) have been reported to blunt the hypotensive effect of systemic clonidine; unknown whether the concurrent use TCAs with brimonidine ophthalmic can interfere with IOP lowering effect
            • MAOIs may theoretically interfere with the metabolism of brimonidine and potentially result in increased systemic effects (eg, hypotension); advise caution to patients taking MAO inhibitors
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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: It is not known whether this drug is excreted in milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Open-Angle Glaucoma or Ocular Hypertension

            • Alpha-2 adrenergic receptor agonist; decreases aqueous humor secretion, increases uveoscleral outflow

            Ocular Redness

            • Dilutes alpha-2 receptor agonist; rapidly eliminates redness along the bulbar conjunctival microvasculature

            Pharmacokinetics

            Onset of action: 2hr (peak effect)

            Half-Life: 2 hr

            Peak plasma time: 0.5-2.5 hr

            Metabolism: Liver

            Excretion: urine (74%)

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            Images

            BRAND FORM. UNIT PRICE PILL IMAGE
            Mirvaso topical
            -
            0.33 % gel
            Mirvaso topical
            -
            0.33 % gel
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.15 % drops
            brimonidine ophthalmic (eye)
            -
            0.15 % drops
            brimonidine ophthalmic (eye)
            -
            0.15 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            brimonidine ophthalmic (eye)
            -
            0.2 % drops
            Alphagan P ophthalmic (eye)
            -
            0.1 % drops
            Alphagan P ophthalmic (eye)
            -
            0.1 % drops
            Alphagan P ophthalmic (eye)
            -
            0.1 % drops
            Alphagan P ophthalmic (eye)
            -
            0.15 % drops
            Alphagan P ophthalmic (eye)
            -
            0.15 % drops
            Alphagan P ophthalmic (eye)
            -
            0.15 % drops

            Copyright © 2010 First DataBank, Inc.

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            Patient Handout

            Select a drug:
            Patient Education
            brimonidine topical

            BRIMONIDINE GEL - TOPICAL

            (bri-MON-i-deen)

            COMMON BRAND NAME(S): Mirvaso

            USES: This medication is used to treat a certain skin disorder called rosacea. It works by narrowing blood vessels to reduce redness. Brimonidine belongs to a class of drugs known as alpha agonists.

            HOW TO USE: Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using this drug and each time you get a refill. If you have any questions, ask your doctor or pharmacist.This medication is for use on the skin only. Avoid getting this medication into your eyes or mouth, on your lips, on any areas of broken/irritated skin including after laser treatment, or in and around the vaginal area.Wash your hands before and after applying this medication. Clean and dry the affected area before applying the medication. Apply a pea-sized amount of the medication to the affected area(s) (such as the forehead, chin, nose, and each cheek) and gently spread a thin layer of the medication over that area as directed by your doctor, usually once daily.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.To reduce your risk of side effects, your doctor may direct you to apply a smaller amount of medication at first and gradually increase your dose. Follow your doctor's instructions carefully.Tell your doctor if your condition does not improve or if it worsens.Keep this medicine in a safe place to prevent accidental use or misuse. Children who have accidentally swallowed this medication have had serious side effects, including trouble breathing, weakness, slow heartbeat, confusion, sweating. If a child swallows this drug, get medical help right away.

            SIDE EFFECTS: Flushing and redness/burning of the skin may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: slow heartbeat, dizziness, fainting, pale/whitening skin.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

            PRECAUTIONS: Before using brimonidine, tell your doctor or pharmacist if you are allergic to it; or to apraclonidine; or if you have any other allergies. This product may contain inactive ingredients (such as phenoxyethanol), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood vessel diseases (thromboangiitis obliterans), blood circulation disorders (cerebral or coronary insufficiency), heart disease, depression, Raynaud's disease, low blood pressure upon standing (orthostatic hypotension), a certain immune system disorder (Sjogren's syndrome), a certain skin/connective tissue disease (scleroderma).Avoid certain triggers that may worsen rosacea such as wind, hot beverages, spicy foods, alcohol, and extreme cold. Discuss with your doctor.Sun exposure can worsen rosacea. Limit exposure to the sun by wearing a wide-brimmed hat and using a sunscreen that is SPF 15 or greater.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

            DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Avoid the use of skin care products that can cause further irritation (such as cleaners that contain alcohol, tinctures, astringents, abrasives, and peeling agents). Consult your doctor or pharmacist for details.

            OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

            NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case.

            MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

            STORAGE: Store at room temperature. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

            Information last revised October 2022. Copyright(c) 2023 First Databank, Inc.

            IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Additional Offers
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.