Suggested Dosing
Migraine, Prophylaxis
Extract
- 50-100 mg PO daily
Fresh leaf
- 2.5 leaves PO daily
Freeze dried leaf
- 50-150 mg PO qD-BID
Suggested Uses
Prevention, control of migraine prophylaxis
Allergies, arthritis, fevers, headaches, menstrual irregularities, migraine prophylaxis, psoriasis, tinnitus, vertigo, cancer
Efficacy
Demonstrated effective to decr severity/frequency of migraine
Not established for rheum. arthritis, other inflammatory conditions (higher doses may be necessary)
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (69)
- aceclofenac
aceclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.
- acemetacin
acemetacin and feverfew both increase anticoagulation. Use Caution/Monitor.
- agrimony
agrimony and feverfew both increase anticoagulation. Use Caution/Monitor.
- alfalfa
alfalfa and feverfew both increase anticoagulation. Use Caution/Monitor.
- alteplase
alteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- American ginseng
American ginseng and feverfew both increase anticoagulation. Use Caution/Monitor.
- antithrombin alfa
antithrombin alfa and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- antithrombin III
antithrombin III and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- argatroban
argatroban and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- aspirin
aspirin and feverfew both increase anticoagulation. Use Caution/Monitor.
- aspirin rectal
aspirin rectal and feverfew both increase anticoagulation. Use Caution/Monitor.
- aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate and feverfew both increase anticoagulation. Use Caution/Monitor.
- bemiparin
bemiparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- bivalirudin
bivalirudin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- celecoxib
celecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.
- choline magnesium trisalicylate
choline magnesium trisalicylate and feverfew both increase anticoagulation. Use Caution/Monitor.
- cinnamon
cinnamon and feverfew both increase anticoagulation. Use Caution/Monitor.
- cordyceps
cordyceps and feverfew both increase anticoagulation. Use Caution/Monitor.
- dabigatran
dabigatran and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- dalteparin
dalteparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- diclofenac
diclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.
- diflunisal
diflunisal and feverfew both increase anticoagulation. Use Caution/Monitor.
- dong quai
dong quai and feverfew both increase anticoagulation. Use Caution/Monitor.
- enoxaparin
enoxaparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- epoprostenol
epoprostenol and feverfew both increase anticoagulation. Use Caution/Monitor.
- etodolac
etodolac and feverfew both increase anticoagulation. Use Caution/Monitor.
- fennel
fennel and feverfew both increase anticoagulation. Use Caution/Monitor.
- fenoprofen
fenoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
- flurbiprofen
flurbiprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
- fondaparinux
fondaparinux and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- forskolin
feverfew and forskolin both increase anticoagulation. Use Caution/Monitor.
- garlic
feverfew and garlic both increase anticoagulation. Use Caution/Monitor.
- ginger
feverfew and ginger both increase anticoagulation. Use Caution/Monitor.
- ginkgo biloba
feverfew and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.
- heparin
heparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- horse chestnut seed
feverfew and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.
- ibuprofen
ibuprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
- ibuprofen IV
ibuprofen IV and feverfew both increase anticoagulation. Use Caution/Monitor.
- indomethacin
indomethacin and feverfew both increase anticoagulation. Use Caution/Monitor.
- ketoprofen
ketoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
- ketorolac
ketorolac and feverfew both increase anticoagulation. Use Caution/Monitor.
- ketorolac intranasal
ketorolac intranasal and feverfew both increase anticoagulation. Use Caution/Monitor.
- lornoxicam
lornoxicam and feverfew both increase anticoagulation. Use Caution/Monitor.
- meclofenamate
meclofenamate and feverfew both increase anticoagulation. Use Caution/Monitor.
- mefenamic acid
mefenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.
- meloxicam
meloxicam and feverfew both increase anticoagulation. Use Caution/Monitor.
- mistletoe
feverfew increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nabumetone
nabumetone and feverfew both increase anticoagulation. Use Caution/Monitor.
- naproxen
naproxen and feverfew both increase anticoagulation. Use Caution/Monitor.
- nettle
feverfew increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- oxaprozin
oxaprozin and feverfew both increase anticoagulation. Use Caution/Monitor.
- panax ginseng
feverfew and panax ginseng both increase anticoagulation. Use Caution/Monitor.
- parecoxib
parecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.
- pau d'arco
feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.
- phenindione
phenindione and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- phytoestrogens
feverfew and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
- piroxicam
piroxicam and feverfew both increase anticoagulation. Use Caution/Monitor.
- protamine
protamine and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- reishi
feverfew and reishi both increase anticoagulation. Use Caution/Monitor.
- reteplase
reteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- salicylates (non-asa)
salicylates (non-asa) and feverfew both increase anticoagulation. Use Caution/Monitor.
- salsalate
salsalate and feverfew both increase anticoagulation. Use Caution/Monitor.
- Siberian ginseng
feverfew and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
- sulfasalazine
sulfasalazine and feverfew both increase anticoagulation. Use Caution/Monitor.
- sulindac
sulindac and feverfew both increase anticoagulation. Use Caution/Monitor.
- tenecteplase
tenecteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
- tolfenamic acid
tolfenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.
- tolmetin
tolmetin and feverfew both increase anticoagulation. Use Caution/Monitor.
- vitamin K1 (phytonadione)
feverfew increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Minor (47)
- aceclofenac
aceclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- acemetacin
acemetacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- anamu
anamu and feverfew both increase anticoagulation. Minor/Significance Unknown.
- aspirin
aspirin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- aspirin rectal
aspirin rectal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- budesonide
budesonide decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- celecoxib
celecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- choline magnesium trisalicylate
choline magnesium trisalicylate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- cortisone
cortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- danshen
danshen and feverfew both increase anticoagulation. Minor/Significance Unknown.
- deflazacort
deflazacort decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- devil's claw
devil's claw and feverfew both increase anticoagulation. Minor/Significance Unknown.
- dexamethasone
dexamethasone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- diclofenac
diclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- diflunisal
diflunisal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- etodolac
etodolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- fenoprofen
fenoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- fludrocortisone
fludrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- flurbiprofen
flurbiprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- green tea
green tea, feverfew. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.
- hydrocortisone
hydrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- ibuprofen
ibuprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- ibuprofen IV
ibuprofen IV decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- indomethacin
indomethacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- ketoprofen
ketoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- ketorolac
ketorolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- ketorolac intranasal
ketorolac intranasal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- lornoxicam
lornoxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- meclofenamate
meclofenamate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- mefenamic acid
mefenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- meloxicam
meloxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- methylprednisolone
methylprednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- nabumetone
nabumetone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- naproxen
naproxen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- oxaprozin
oxaprozin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- parecoxib
parecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- piroxicam
piroxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- prednisolone
prednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- prednisone
prednisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- salicylates (non-asa)
salicylates (non-asa) decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- salsalate
salsalate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- sulfasalazine
sulfasalazine decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- sulindac
sulindac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- tolfenamic acid
tolfenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- tolmetin
tolmetin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
- triamcinolone acetonide injectable suspension
triamcinolone acetonide injectable suspension decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Abdominal pain
Allergic reaction
Diarrhea
Flatulence
Indigestion
Mouth ulcers
Nausea/vomiting
Anxiety (chronic use)
Headache (chronic use)
Insomnia (chronic use)
Muscle/joint stiffness (chronic use)
Warnings
Contraindications
Lactation, pregnancy, ragweed allergies
Hypersensitivity to Asteraceae/Compositae plants
Hypersensitivity to chrysanthemums, daisies, marigolds
Cautions
Quality of products vary widely; depends on content of parthenolide
Min. parthenolide content should be 0.2
Pregnancy & Lactation
Pregnancy Category: unsafe
Lactation: unsafe
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Metabolism: N/A
Excretion: N/A
Mechanism of Action
Sesquiterpene lactones, incl. parthenolide: inhib. release of arachidonic acid
Inhib. platelet and leukocytes secretion of serotonin, histamine
