Feverfew (Herb/Suppl)

Brand and Other Names:altamisa, bachelor button, more...camomille grande, chrysanthemum parthenium, featherfew, featherfoil, flirtwort midsummer daisy, midsummer daisy, Santa Maria, tanacetum parthenium
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Suggested Dosing

Migraine, Prophylaxis

Extract

  • 50-100 mg PO daily

Fresh leaf

  • 2.5 leaves PO daily

Freeze dried leaf

  • 50-150 mg PO qD-BID
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Suggested Uses

Prevention, control of migraine prophylaxis

Allergies, arthritis, fevers, headaches, menstrual irregularities, migraine prophylaxis, psoriasis, tinnitus, vertigo, cancer

Efficacy

Demonstrated effective to decr severity/frequency of migraine

Not established for rheum. arthritis, other inflammatory conditions (higher doses may be necessary)

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Interactions

Interaction Checker

and Feverfew

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (69)

                • aceclofenac

                  aceclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.

                • acemetacin

                  acemetacin and feverfew both increase anticoagulation. Use Caution/Monitor.

                • agrimony

                  agrimony and feverfew both increase anticoagulation. Use Caution/Monitor.

                • alfalfa

                  alfalfa and feverfew both increase anticoagulation. Use Caution/Monitor.

                • alteplase

                  alteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • American ginseng

                  American ginseng and feverfew both increase anticoagulation. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin and feverfew both increase anticoagulation. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal and feverfew both increase anticoagulation. Use Caution/Monitor.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate and feverfew both increase anticoagulation. Use Caution/Monitor.

                • bemiparin

                  bemiparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • bivalirudin

                  bivalirudin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate and feverfew both increase anticoagulation. Use Caution/Monitor.

                • cinnamon

                  cinnamon and feverfew both increase anticoagulation. Use Caution/Monitor.

                • cordyceps

                  cordyceps and feverfew both increase anticoagulation. Use Caution/Monitor.

                • dabigatran

                  dabigatran and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • dalteparin

                  dalteparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • diclofenac

                  diclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.

                • diflunisal

                  diflunisal and feverfew both increase anticoagulation. Use Caution/Monitor.

                • dong quai

                  dong quai and feverfew both increase anticoagulation. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • epoprostenol

                  epoprostenol and feverfew both increase anticoagulation. Use Caution/Monitor.

                • etodolac

                  etodolac and feverfew both increase anticoagulation. Use Caution/Monitor.

                • fennel

                  fennel and feverfew both increase anticoagulation. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.

                • flurbiprofen

                  flurbiprofen and feverfew both increase anticoagulation. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • forskolin

                  feverfew and forskolin both increase anticoagulation. Use Caution/Monitor.

                • garlic

                  feverfew and garlic both increase anticoagulation. Use Caution/Monitor.

                • ginger

                  feverfew and ginger both increase anticoagulation. Use Caution/Monitor.

                • ginkgo biloba

                  feverfew and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

                • heparin

                  heparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  feverfew and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen and feverfew both increase anticoagulation. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV and feverfew both increase anticoagulation. Use Caution/Monitor.

                • indomethacin

                  indomethacin and feverfew both increase anticoagulation. Use Caution/Monitor.

                • ketoprofen

                  ketoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.

                • ketorolac

                  ketorolac and feverfew both increase anticoagulation. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal and feverfew both increase anticoagulation. Use Caution/Monitor.

                • lornoxicam

                  lornoxicam and feverfew both increase anticoagulation. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate and feverfew both increase anticoagulation. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.

                • meloxicam

                  meloxicam and feverfew both increase anticoagulation. Use Caution/Monitor.

                • mistletoe

                  feverfew increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nabumetone

                  nabumetone and feverfew both increase anticoagulation. Use Caution/Monitor.

                • naproxen

                  naproxen and feverfew both increase anticoagulation. Use Caution/Monitor.

                • nettle

                  feverfew increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin and feverfew both increase anticoagulation. Use Caution/Monitor.

                • panax ginseng

                  feverfew and panax ginseng both increase anticoagulation. Use Caution/Monitor.

                • parecoxib

                  parecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.

                • pau d'arco

                  feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.

                • phenindione

                  phenindione and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • phytoestrogens

                  feverfew and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

                • piroxicam

                  piroxicam and feverfew both increase anticoagulation. Use Caution/Monitor.

                • protamine

                  protamine and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • reishi

                  feverfew and reishi both increase anticoagulation. Use Caution/Monitor.

                • reteplase

                  reteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • salicylates (non-asa)

                  salicylates (non-asa) and feverfew both increase anticoagulation. Use Caution/Monitor.

                • salsalate

                  salsalate and feverfew both increase anticoagulation. Use Caution/Monitor.

                • Siberian ginseng

                  feverfew and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

                • sulfasalazine

                  sulfasalazine and feverfew both increase anticoagulation. Use Caution/Monitor.

                • sulindac

                  sulindac and feverfew both increase anticoagulation. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.

                • tolfenamic acid

                  tolfenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.

                • tolmetin

                  tolmetin and feverfew both increase anticoagulation. Use Caution/Monitor.

                • vitamin K1 (phytonadione)

                  feverfew increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                Minor (47)

                • aceclofenac

                  aceclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • acemetacin

                  acemetacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • anamu

                  anamu and feverfew both increase anticoagulation. Minor/Significance Unknown.

                • aspirin

                  aspirin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • aspirin rectal

                  aspirin rectal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • budesonide

                  budesonide decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • celecoxib

                  celecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • cortisone

                  cortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • danshen

                  danshen and feverfew both increase anticoagulation. Minor/Significance Unknown.

                • deflazacort

                  deflazacort decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • devil's claw

                  devil's claw and feverfew both increase anticoagulation. Minor/Significance Unknown.

                • dexamethasone

                  dexamethasone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • diclofenac

                  diclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • diflunisal

                  diflunisal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • etodolac

                  etodolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • fenoprofen

                  fenoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • fludrocortisone

                  fludrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • flurbiprofen

                  flurbiprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • green tea

                  green tea, feverfew. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.

                • hydrocortisone

                  hydrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • ibuprofen

                  ibuprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • ibuprofen IV

                  ibuprofen IV decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • indomethacin

                  indomethacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • ketoprofen

                  ketoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • ketorolac

                  ketorolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • ketorolac intranasal

                  ketorolac intranasal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • lornoxicam

                  lornoxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • meclofenamate

                  meclofenamate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • mefenamic acid

                  mefenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • meloxicam

                  meloxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • methylprednisolone

                  methylprednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • nabumetone

                  nabumetone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • naproxen

                  naproxen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • oxaprozin

                  oxaprozin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • parecoxib

                  parecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • piroxicam

                  piroxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • prednisolone

                  prednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • prednisone

                  prednisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • salicylates (non-asa)

                  salicylates (non-asa) decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • salsalate

                  salsalate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • sulfasalazine

                  sulfasalazine decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • sulindac

                  sulindac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • tolfenamic acid

                  tolfenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • tolmetin

                  tolmetin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

                • triamcinolone acetonide injectable suspension

                  triamcinolone acetonide injectable suspension decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Abdominal pain

                Allergic reaction

                Diarrhea

                Flatulence

                Indigestion

                Mouth ulcers

                Nausea/vomiting

                Anxiety (chronic use)

                Headache (chronic use)

                Insomnia (chronic use)

                Muscle/joint stiffness (chronic use)

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                Warnings

                Contraindications

                Lactation, pregnancy, ragweed allergies

                Hypersensitivity to Asteraceae/Compositae plants

                Hypersensitivity to chrysanthemums, daisies, marigolds

                Cautions

                Quality of products vary widely; depends on content of parthenolide

                Min. parthenolide content should be 0.2

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                Pregnancy & Lactation

                Pregnancy Category: unsafe

                Lactation: unsafe

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Sesquiterpene lactones, incl. parthenolide: inhib. release of arachidonic acid

                Inhib. platelet and leukocytes secretion of serotonin, histamine

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.