Indication-specific dosing for altamisa, bachelor button, camomille grande feverfew in combination, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Feverfew
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

Migraine, Prophylaxis

Extract

50-100 mg PO daily

Fresh leaf

2.5 leaves PO daily

Freeze dried leaf

50-150 mg PO qD-BID

Suggested Uses

Prevention, control of migraine prophylaxis

Allergies, arthritis, fevers, headaches, menstrual irregularities, migraine prophylaxis, psoriasis, tinnitus, vertigo, cancer

Efficacy

Demonstrated effective to decr severity/frequency of migraine

Not established for rheum. arthritis, other inflammatory conditions (higher doses may be necessary)

Interaction Checker

Enter a drug name and Feverfew

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Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

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Contraindicated (0)

Serious - Use Alternative (0)

Monitor Closely (69)

aceclofenac
aceclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.
acemetacin
acemetacin and feverfew both increase anticoagulation. Use Caution/Monitor.
agrimony
agrimony and feverfew both increase anticoagulation. Use Caution/Monitor.
alfalfa
alfalfa and feverfew both increase anticoagulation. Use Caution/Monitor.
alteplase
alteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
American ginseng
American ginseng and feverfew both increase anticoagulation. Use Caution/Monitor.
antithrombin alfa
antithrombin alfa and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
antithrombin III
antithrombin III and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
argatroban
argatroban and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
aspirin
aspirin and feverfew both increase anticoagulation. Use Caution/Monitor.
aspirin rectal
aspirin rectal and feverfew both increase anticoagulation. Use Caution/Monitor.
aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate and feverfew both increase anticoagulation. Use Caution/Monitor.
bemiparin
bemiparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
bivalirudin
bivalirudin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
celecoxib
celecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.
choline magnesium trisalicylate
choline magnesium trisalicylate and feverfew both increase anticoagulation. Use Caution/Monitor.
cinnamon
cinnamon and feverfew both increase anticoagulation. Use Caution/Monitor.
cordyceps
cordyceps and feverfew both increase anticoagulation. Use Caution/Monitor.
dabigatran
dabigatran and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
dalteparin
dalteparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
diclofenac
diclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.
diflunisal
diflunisal and feverfew both increase anticoagulation. Use Caution/Monitor.
dong quai
dong quai and feverfew both increase anticoagulation. Use Caution/Monitor.
enoxaparin
enoxaparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
epoprostenol
epoprostenol and feverfew both increase anticoagulation. Use Caution/Monitor.
etodolac
etodolac and feverfew both increase anticoagulation. Use Caution/Monitor.
fennel
fennel and feverfew both increase anticoagulation. Use Caution/Monitor.
fenoprofen
fenoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
flurbiprofen
flurbiprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
fondaparinux
fondaparinux and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
forskolin
feverfew and forskolin both increase anticoagulation. Use Caution/Monitor.
garlic
feverfew and garlic both increase anticoagulation. Use Caution/Monitor.
ginger
feverfew and ginger both increase anticoagulation. Use Caution/Monitor.
ginkgo biloba
feverfew and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.
heparin
heparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
horse chestnut seed
feverfew and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.
ibuprofen
ibuprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
ibuprofen IV
ibuprofen IV and feverfew both increase anticoagulation. Use Caution/Monitor.
indomethacin
indomethacin and feverfew both increase anticoagulation. Use Caution/Monitor.
ketoprofen
ketoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
ketorolac
ketorolac and feverfew both increase anticoagulation. Use Caution/Monitor.
ketorolac intranasal
ketorolac intranasal and feverfew both increase anticoagulation. Use Caution/Monitor.
lornoxicam
lornoxicam and feverfew both increase anticoagulation. Use Caution/Monitor.
meclofenamate
meclofenamate and feverfew both increase anticoagulation. Use Caution/Monitor.
mefenamic acid
mefenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.
meloxicam
meloxicam and feverfew both increase anticoagulation. Use Caution/Monitor.
mistletoe
feverfew increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nabumetone
nabumetone and feverfew both increase anticoagulation. Use Caution/Monitor.
naproxen
naproxen and feverfew both increase anticoagulation. Use Caution/Monitor.
nettle
feverfew increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
oxaprozin
oxaprozin and feverfew both increase anticoagulation. Use Caution/Monitor.
panax ginseng
feverfew and panax ginseng both increase anticoagulation. Use Caution/Monitor.
parecoxib
parecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.
pau d'arco
feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.
phenindione
phenindione and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
phytoestrogens
feverfew and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
piroxicam
piroxicam and feverfew both increase anticoagulation. Use Caution/Monitor.
protamine
protamine and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
reishi
feverfew and reishi both increase anticoagulation. Use Caution/Monitor.
reteplase
reteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
salicylates (non-asa)
salicylates (non-asa) and feverfew both increase anticoagulation. Use Caution/Monitor.
salsalate
salsalate and feverfew both increase anticoagulation. Use Caution/Monitor.
Siberian ginseng
feverfew and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
sulfasalazine
sulfasalazine and feverfew both increase anticoagulation. Use Caution/Monitor.
sulindac
sulindac and feverfew both increase anticoagulation. Use Caution/Monitor.
tenecteplase
tenecteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
tolfenamic acid
tolfenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.
tolmetin
tolmetin and feverfew both increase anticoagulation. Use Caution/Monitor.
vitamin K1 (phytonadione)
feverfew increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

Minor (47)

aceclofenac
aceclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
acemetacin
acemetacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
anamu
anamu and feverfew both increase anticoagulation. Minor/Significance Unknown.
aspirin
aspirin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
aspirin rectal
aspirin rectal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
budesonide
budesonide decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
celecoxib
celecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
choline magnesium trisalicylate
choline magnesium trisalicylate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
cortisone
cortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
danshen
danshen and feverfew both increase anticoagulation. Minor/Significance Unknown.
deflazacort
deflazacort decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
devil's claw
devil's claw and feverfew both increase anticoagulation. Minor/Significance Unknown.
dexamethasone
dexamethasone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
diclofenac
diclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
diflunisal
diflunisal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
etodolac
etodolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
fenoprofen
fenoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
fludrocortisone
fludrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
flurbiprofen
flurbiprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
green tea
green tea, feverfew. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.
hydrocortisone
hydrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ibuprofen
ibuprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ibuprofen IV
ibuprofen IV decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
indomethacin
indomethacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ketoprofen
ketoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ketorolac
ketorolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ketorolac intranasal
ketorolac intranasal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
lornoxicam
lornoxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
meclofenamate
meclofenamate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
mefenamic acid
mefenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
meloxicam
meloxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
methylprednisolone
methylprednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
nabumetone
nabumetone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
naproxen
naproxen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
oxaprozin
oxaprozin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
parecoxib
parecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
piroxicam
piroxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
prednisolone
prednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
prednisone
prednisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
salicylates (non-asa)
salicylates (non-asa) decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
salsalate
salsalate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
sulfasalazine
sulfasalazine decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
sulindac
sulindac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
tolfenamic acid
tolfenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
tolmetin
tolmetin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
triamcinolone acetonide injectable suspension
triamcinolone acetonide injectable suspension decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

aceclofenac
Monitor Closely (1)aceclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)aceclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
acemetacin
Monitor Closely (1)acemetacin and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)acemetacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
agrimony
Monitor Closely (1)agrimony and feverfew both increase anticoagulation. Use Caution/Monitor.
alfalfa
Monitor Closely (1)alfalfa and feverfew both increase anticoagulation. Use Caution/Monitor.
alteplase
Monitor Closely (1)alteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
American ginseng
Monitor Closely (1)American ginseng and feverfew both increase anticoagulation. Use Caution/Monitor.
anamu
Minor (1)anamu and feverfew both increase anticoagulation. Minor/Significance Unknown.
antithrombin alfa
Monitor Closely (1)antithrombin alfa and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
antithrombin III
Monitor Closely (1)antithrombin III and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
argatroban
Monitor Closely (1)argatroban and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
aspirin
Monitor Closely (1)aspirin and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)aspirin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
aspirin rectal
Monitor Closely (1)aspirin rectal and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)aspirin rectal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
aspirin/citric acid/sodium bicarbonate
Monitor Closely (1)aspirin/citric acid/sodium bicarbonate and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)aspirin/citric acid/sodium bicarbonate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
bemiparin
Monitor Closely (1)bemiparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
bivalirudin
Monitor Closely (1)bivalirudin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
budesonide
Minor (1)budesonide decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
celecoxib
Monitor Closely (1)celecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)celecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
choline magnesium trisalicylate
Monitor Closely (1)choline magnesium trisalicylate and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)choline magnesium trisalicylate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
cinnamon
Monitor Closely (1)cinnamon and feverfew both increase anticoagulation. Use Caution/Monitor.
cordyceps
Monitor Closely (1)cordyceps and feverfew both increase anticoagulation. Use Caution/Monitor.
cortisone
Minor (1)cortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
dabigatran
Monitor Closely (1)dabigatran and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
dalteparin
Monitor Closely (1)dalteparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
danshen
Minor (1)danshen and feverfew both increase anticoagulation. Minor/Significance Unknown.
deflazacort
Minor (1)deflazacort decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
devil's claw
Minor (1)devil's claw and feverfew both increase anticoagulation. Minor/Significance Unknown.
dexamethasone
Minor (1)dexamethasone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
diclofenac
Monitor Closely (1)diclofenac and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)diclofenac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
diflunisal
Monitor Closely (1)diflunisal and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)diflunisal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
dong quai
Monitor Closely (1)dong quai and feverfew both increase anticoagulation. Use Caution/Monitor.
enoxaparin
Monitor Closely (1)enoxaparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
epoprostenol
Monitor Closely (1)epoprostenol and feverfew both increase anticoagulation. Use Caution/Monitor.
etodolac
Monitor Closely (1)etodolac and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)etodolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
fennel
Monitor Closely (1)fennel and feverfew both increase anticoagulation. Use Caution/Monitor.
fenoprofen
Monitor Closely (1)fenoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)fenoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
fludrocortisone
Minor (1)fludrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
flurbiprofen
Monitor Closely (1)flurbiprofen and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)flurbiprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
fondaparinux
Monitor Closely (1)fondaparinux and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
forskolin
Monitor Closely (1)feverfew and forskolin both increase anticoagulation. Use Caution/Monitor.
garlic
Monitor Closely (1)feverfew and garlic both increase anticoagulation. Use Caution/Monitor.
ginger
Monitor Closely (1)feverfew and ginger both increase anticoagulation. Use Caution/Monitor.
ginkgo biloba
Monitor Closely (1)feverfew and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.
green tea
Minor (1)green tea, feverfew. Other (see comment). Minor/Significance Unknown. Comment: Use caution when combining green tea with herbs that exhibit antiplatelet effects or anticoagulant activity.
heparin
Monitor Closely (1)heparin and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
horse chestnut seed
Monitor Closely (1)feverfew and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.
hydrocortisone
Minor (1)hydrocortisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ibuprofen
Monitor Closely (1)ibuprofen and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)ibuprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ibuprofen IV
Monitor Closely (1)ibuprofen IV and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)ibuprofen IV decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
indomethacin
Monitor Closely (1)indomethacin and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)indomethacin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ketoprofen
Monitor Closely (1)ketoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)ketoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ketorolac
Monitor Closely (1)ketorolac and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)ketorolac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
ketorolac intranasal
Monitor Closely (1)ketorolac intranasal and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)ketorolac intranasal decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
lornoxicam
Monitor Closely (1)lornoxicam and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)lornoxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
meclofenamate
Monitor Closely (1)meclofenamate and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)meclofenamate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
mefenamic acid
Monitor Closely (1)mefenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)mefenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
meloxicam
Monitor Closely (1)meloxicam and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)meloxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
methylprednisolone
Minor (1)methylprednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
mistletoe
Monitor Closely (1)feverfew increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nabumetone
Monitor Closely (1)nabumetone and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)nabumetone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
naproxen
Monitor Closely (1)naproxen and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)naproxen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
nettle
Monitor Closely (1)feverfew increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
oxaprozin
Monitor Closely (1)oxaprozin and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)oxaprozin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
panax ginseng
Monitor Closely (1)feverfew and panax ginseng both increase anticoagulation. Use Caution/Monitor.
parecoxib
Monitor Closely (1)parecoxib and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)parecoxib decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
pau d'arco
Monitor Closely (1)feverfew and pau d'arco both increase anticoagulation. Use Caution/Monitor.
phenindione
Monitor Closely (1)phenindione and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
phytoestrogens
Monitor Closely (1)feverfew and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
piroxicam
Monitor Closely (1)piroxicam and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)piroxicam decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
prednisolone
Minor (1)prednisolone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
prednisone
Minor (1)prednisone decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
protamine
Monitor Closely (1)protamine and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
reishi
Monitor Closely (1)feverfew and reishi both increase anticoagulation. Use Caution/Monitor.
reteplase
Monitor Closely (1)reteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
salicylates (non-asa)
Monitor Closely (1)salicylates (non-asa) and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)salicylates (non-asa) decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
salsalate
Monitor Closely (1)salsalate and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)salsalate decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
Siberian ginseng
Monitor Closely (1)feverfew and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
sulfasalazine
Monitor Closely (1)sulfasalazine and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)sulfasalazine decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
sulindac
Monitor Closely (1)sulindac and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)sulindac decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
tenecteplase
Monitor Closely (1)tenecteplase and feverfew both increase anticoagulation. Modify Therapy/Monitor Closely.
tolfenamic acid
Monitor Closely (1)tolfenamic acid and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)tolfenamic acid decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
tolmetin
Monitor Closely (1)tolmetin and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)tolmetin decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
triamcinolone acetonide injectable suspension
Minor (1)triamcinolone acetonide injectable suspension decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.
vitamin K1 (phytonadione)
Monitor Closely (1)feverfew increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

Frequency Not Defined

Abdominal pain

Allergic reaction

Diarrhea

Flatulence

Indigestion

Mouth ulcers

Nausea/vomiting

Anxiety (chronic use)

Headache (chronic use)

Insomnia (chronic use)

Muscle/joint stiffness (chronic use)

Contraindications

Lactation, pregnancy, ragweed allergies

Hypersensitivity to Asteraceae/Compositae plants

Hypersensitivity to chrysanthemums, daisies, marigolds

Cautions

Quality of products vary widely; depends on content of parthenolide

Min. parthenolide content should be 0.2

Pregnancy & Lactation

Pregnancy Category: unsafe

Lactation: unsafe

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Sesquiterpene lactones, incl. parthenolide: inhib. release of arachidonic acid

Inhib. platelet and leukocytes secretion of serotonin, histamine

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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