Dosing & Uses
Dosage Forms & Strengths
oral suspension
- 320mg/5mL
Antacid
5-30 mL PO between meals and HS or as directed
Peptic Ulcer Disease
5-30 mL between meals and HS or as directed
Hyperphosphatemia
300-600 mg PO 3 times/day between meals and HS
Dosage Forms & Strengths
oral suspension
- 320mg/5mL
Hyperphosphatemia
50-150 mg/kg/day PO divided q4-6hr; titrate dose to keep phosphorus within normal range
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Adverse Effects
Frequency Not Defined
Nausea
Vomiting
Rebound hyperacidity
Aluminum-intoxication
Hypophosphatemia
Chalky taste
Constipation
Fecal impaction
Stomach cramps
Milk-alkali syndrome
Osteomalacia
Warnings
Contraindications
Hypersensitivity to aluminum salts
Cautions
Aluminum toxicity may occur in renal failure patients
Hypophosphatemia may occur
Use caution in patients with heart failure, cirrhosis, edema, or renal failure
Will bind calcium if given at same time
Elderly may be predisposed to fecal impaction
Use caution in patients who have recently suffered massive gastrointestinal hemorrhage
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Not known whether aluminum hydroxide is excreted in breast milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Antacid: Neutralizes HCl in the stomach to form soluble aluminum chloride
Phosphate binder: binds phosphate in the GI tract to form insoluble complexes and reduces phosphate absorption
Pharmacokinetics
Excretion
- Absorbed aluminum is eliminated in the urine (0.1-0.5 mg of Al in aluminum-containing antacid is absorbed from standard daily doses of antacid)
- Insoluble, poorly absorbed Al salts in the intestines: hydroxides, carbonates, phosphates and fatty acid derivatives, are excreted in feces
Administration
Oral Administration
Drink plenty of water following dose